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B2HKN9 (B2HKN9_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:lytB2 EMBL ACC38744.1
Synonyms:ispH1 HAMAP MF_00191
Ordered Locus Names:MMAR_0277
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B2HKN9 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 75AC07F009D9AE47

FASTA33335,648
        10         20         30         40         50         60 
MTTVNPSSRS RPRPLADESA ATTVLLASPR SFCAGVHRAI EAVERVLDRA TGPVYVRKQI 

        70         80         90        100        110        120 
VHNRTVVAEL QDRGAIFVDE LDEIPDPPAP GAVVVFSAHG VSPAVRAAAN GRGLEVVDAT 

       130        140        150        160        170        180 
CPLVTKVHAE AARFAGRGDT VLLIGHLGHE ETDGTLGVAP NSMLLVQNAD DVTELDLPED 

       190        200        210        220        230        240 
AQVSYLTQTT LAVDETTDVI DALRKRFPKL AEPPTEDICY ATTNRQRAVE AIVRRCDALL 

       250        260        270        280        290        300 
VVGSQNSSNS QRLVELARRR GTPAYLIDGP TDIDPHWLDS TATIGITAGA SAPPRLVEQV 

       310        320        330 
IDALRLRGPI NVVESPVTTE SVRFALPPKV RVP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC38744.1.
RefSeqYP_001848599.1. NC_010612.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2HKN9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000035531; EBMYCP00000033971; EBMYCG00000035526.
GeneID6224491.
GenomeReviewsGene locus MMAR_0277 in contig CP000854_GR.
KEGGmmi:MMAR_0277.
PATRIC18061239. VBIMycMar75906_0313.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016858.
HOGENOMHBG335228.
OMAHNQGKRY.
ProtClustDBCLSK799986.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2HKN9_MYCMM
AccessionPrimary (citable) accession number: B2HKN9
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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