B2HJU4 (MQO_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	MMAR_1881

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_1000099876

Sequences

	Sequence		Length	Mass (Da)
	B2HJU4 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 2CB37A58630F54DE	FASTA	493	53,718
	10 20 30 40 50 60 MSESARTDVV LVGAGIMSAT LGAMLRRLEP DWSITLIERL DAVAAESSGP WNNAGTGHSA 70 80 90 100 110 120 LCELNYTPQR PDGSIDISKA VRINEEFQVT RQFWAYAAEN GILNDVRSFL NPLPHVSFVH 130 140 150 160 170 180 GAERVHQLRR RRDALAGNPL FAGAEWIDDP DEFARRLPLM AAKRVFSEPI ALNWAADGTD 190 200 210 220 230 240 VDFGALSRQL IGYCVRNGAV ALFGQEVRNL VRQPDGGWML TVVNRRTGEK RKLKTKFVFV 250 260 270 280 290 300 GAGGNALSLL QRSGIKEING FAGFPIGGRF LRTANPALTA AHRAKVYGVP APGAPPLGAL 310 320 330 340 350 360 HLDLRYVNGK SWLMFGPFAG WSPKFLKRGH LRDLPGSIKP NNILSMVGVG VTQVTLLNYL 370 380 390 400 410 420 IGQLRLSEPD RVAVLRKFVP SAADSDWELI VAGQRVQVIR RDKRKGGVLE FGTTVVGEAD 430 440 450 460 470 480 GSIAGLLGGS PGASTAVPIM LEVLQRCFTH RYQSWLPALK EMVPSLGANL SEEPVLYDEV 490 RSWSSRALQL DAS

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-535 / M.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40330.1.
RefSeq	YP_001850185.1. NC_010612.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2HJU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000030999; EBMYCP00000029439; EBMYCG00000030994.
GeneID	6226140.
GenomeReviews	Gene locus MMAR_1881 in contig CP000854_GR.
KEGG	mmi:MMAR_1881.
PATRIC	18064661. VBIMycMar75906_2015.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015585.
HOGENOM	HBG289663.
OMA	KKWVPLM.
ProtClustDB	PRK05257.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_MYCMM

Accession

Primary (citable) accession number: B2HJU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program