B2HJN3 (EFTS_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor Ts
Short name=EF-Ts

Gene names

Name:	tsf
Ordered Locus Names:	MMAR_1820

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome By similarity. HAMAP MF_00050
Subcellular location	Cytoplasm By similarity HAMAP MF_00050.
Sequence similarities	Belongs to the EF-Ts family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Elongation factor Ts HAMAP MF_00050		PRO_1000116764
Regions
	Region	76 – 79	4	Involved in Mg(2+) ion dislocation from EF-Tu By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2HJN3 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 929F5A07CF11CB05	FASTA	271	28,517
	10 20 30 40 50 60 MANFTAADVK RLRELTGAGM LACKNALAES DGDFDKAVEA LRIKGAKDVG KRAERATAEG 70 80 90 100 110 120 LVAAKDGALI ELNCETDFVA KNAEFQKLAD DIVAAAVASK AADVDALKAA SIGGQTVEEA 130 140 150 160 170 180 IGALSAKIGE KLELRRVAIF GGTVETYLHR RAADLPPAVG VLVEYTGAGA EAAHAVALQI 190 200 210 220 230 240 AALKARYLSR EDVPEDLVAS ERRIAEETAK EEGKPEQALP KIVEGRLNGF FKDAVLLEQP 250 260 270 SVSDSKKSVK ALLDDAGVTV TQFVRFEVGQ A

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-535 / M.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40269.1.
RefSeq	YP_001850124.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HJN3.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HJN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000031097; EBMYCP00000029537; EBMYCG00000031092.
GeneID	6226079.
GenomeReviews	Gene locus MMAR_1820 in contig CP000854_GR.
KEGG	mmi:MMAR_1820.
PATRIC	18064519. VBIMycMar75906_1944.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016347.
HOGENOM	HBG713289.
OMA	YLHGTRI.
ProtClustDB	PRK09377.
Family and domain databases
HAMAP	MF_00050. EF_Ts. [Tree]
InterPro	IPR001816. Transl_elong_EFTs/EF1B. IPR014039. Transl_elong_EFTs/EF1B_dimer. IPR018101. Transl_elong_Ts_CS. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. [Graphical view]
Gene3D	G3DSA:3.30.479.20. Transl_elong_EFTs/EF1B_dimer. 3 hits.
KO	K02357.
PANTHER	PTHR11741. Transl_elong_EFTs/EF1B. 1 hit.
Pfam	PF00889. EF_TS. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
SUPFAM	SSF54713. EF_TS. 1 hit. SSF46934. UBA_like. 1 hit.
TIGRFAMs	TIGR00116. Tsf. 1 hit.
PROSITE	PS01126. EF_TS_1. 1 hit. PS01127. EF_TS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFTS_MYCMM

Accession

Primary (citable) accession number: B2HJN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program