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B2HIZ6

- B2HIZ6_MYCMM

UniProt

B2HIZ6 - B2HIZ6_MYCMM

Protein
Submitted name:

Arylamine N-acetyltransferase Nat

Gene

nat

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701CoenzymeAImported
    Binding sitei97 – 971CoenzymeAImported
    Binding sitei132 – 1321CoenzymeA; via amide nitrogenImported
    Binding sitei152 – 1521CoenzymeAImported
    Binding sitei220 – 2201CoenzymeAImported
    Binding sitei229 – 2291CoenzymeAImported

    GO - Molecular functioni

    1. acetyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    TransferaseImported

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-5097-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Arylamine N-acetyltransferase NatImported
    Gene namesi
    Name:natImported
    Ordered Locus Names:MMAR_5055Imported
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)Imported
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_5055.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VFBX-ray2.00A1-280[»]
    2VFCX-ray2.70A/B1-280[»]
    3LTWX-ray2.10A1-280[»]
    4B55X-ray2.70A1-280[»]
    4C5PX-ray1.59A1-280[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiB2HIZ6.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2162.
    HOGENOMiHOG000205436.
    KOiK00622.
    OMAiPATHTLM.
    OrthoDBiEOG6D2KV2.

    Family and domain databases

    InterProiIPR001447. Arylamine_N-AcTrfase.
    [Graphical view]
    PANTHERiPTHR11786. PTHR11786. 1 hit.
    PfamiPF00797. Acetyltransf_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2HIZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALDLTGYLD RINYRGATDP TLDVLRDLVS AHTGAIAFEN LDPLMGVPVD    50
    DLSAEALADK LVDRRRGGYC YEHNGLIGYV LAELGYRVRR LAGRVVWLAP 100
    PDAPTPAQTH TVLAVTFPGC QGPYLVDVGF GGMTPTAPLR LETGTVQQTA 150
    LEPYRLDDRG DGLVLQAMVR DEWQALYEFS TLTRPQVDLR VGSWFVSTHP 200
    TSHFVTGLMA ATVADDARWN LMGRNLAIHR RGGTEKILLE DAAAVVDTLG 250
    DRFGINVADV GERGRLEARI DKVCFGAENR 280
    Length:280
    Mass (Da):30,635
    Last modified:June 10, 2008 - v1
    Checksum:i7A8CBC3B199A1B91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC43459.1.
    RefSeqiYP_001853314.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC43459; ACC43459; MMAR_5055.
    GeneIDi6229346.
    KEGGimmi:MMAR_5055.
    PATRICi18071517. VBIMycMar75906_5415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC43459.1 .
    RefSeqi YP_001853314.1. NC_010612.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VFB X-ray 2.00 A 1-280 [» ]
    2VFC X-ray 2.70 A/B 1-280 [» ]
    3LTW X-ray 2.10 A 1-280 [» ]
    4B55 X-ray 2.70 A 1-280 [» ]
    4C5P X-ray 1.59 A 1-280 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_5055.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC43459 ; ACC43459 ; MMAR_5055 .
    GeneIDi 6229346.
    KEGGi mmi:MMAR_5055.
    PATRICi 18071517. VBIMycMar75906_5415.

    Phylogenomic databases

    eggNOGi COG2162.
    HOGENOMi HOG000205436.
    KOi K00622.
    OMAi PATHTLM.
    OrthoDBi EOG6D2KV2.

    Enzyme and pathway databases

    BioCyci MMAR216594:GJOB-5097-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei B2HIZ6.

    Family and domain databases

    InterProi IPR001447. Arylamine_N-AcTrfase.
    [Graphical view ]
    PANTHERi PTHR11786. PTHR11786. 1 hit.
    Pfami PF00797. Acetyltransf_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / MImported.
    2. "Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase."
      Fullam E., Westwood I.M., Anderton M.C., Lowe E.D., Sim E., Noble M.E.
      J. Mol. Biol. 375:178-191(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH COENZYMEA.
    3. "Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site."
      Abuhammad A.M., Lowe E.D., Fullam E., Noble M., Garman E.F., Sim E.
      Protein Cell 1:384-392(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
    4. "Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages."
      Abuhammad A., Fullam E., Lowe E.D., Staunton D., Kawamura A., Westwood I.M., Bhakta S., Garner A.C., Wilson D.L., Seden P.T., Davies S.G., Russell A.J., Garman E.F., Sim E.
      PLoS ONE 7:e52790-e52790(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS).
    5. "Arylamine N-Acetyltransferases from Mycobacteria: Investigations of a Potential Target for Anti- Tubercular Therapy."
      Abuhammad A.
      Submitted (SEP-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS).

    Entry informationi

    Entry nameiB2HIZ6_MYCMM
    AccessioniPrimary (citable) accession number: B2HIZ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3