Arylamine N-acetyltransferase Nat - Mycobacterium marinum (strain ATCC BAA-535 / M)

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B2HIZ6 (B2HIZ6_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Arylamine N-acetyltransferase Nat EMBL ACC43459.1

Gene names

Name:	nat EMBL ACC43459.1
Ordered Locus Names:	MMAR_5055 EMBL ACC43459.1

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP] EMBL ACC43459.1

Taxonomic identifier

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Transferase EMBL ACC43459.1
Technical term	3D-structure PDB 3LTW PDB 4B55 Complete proteome
Gene Ontology (GO)
Molecular_function	acetyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

B2HIZ6 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 7A8CBC3B199A1B91
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280

30,635

        10         20         30         40         50         60 
MALDLTGYLD RINYRGATDP TLDVLRDLVS AHTGAIAFEN LDPLMGVPVD DLSAEALADK 

        70         80         90        100        110        120 
LVDRRRGGYC YEHNGLIGYV LAELGYRVRR LAGRVVWLAP PDAPTPAQTH TVLAVTFPGC 

       130        140        150        160        170        180 
QGPYLVDVGF GGMTPTAPLR LETGTVQQTA LEPYRLDDRG DGLVLQAMVR DEWQALYEFS 

       190        200        210        220        230        240 
TLTRPQVDLR VGSWFVSTHP TSHFVTGLMA ATVADDARWN LMGRNLAIHR RGGTEKILLE 

       250        260        270        280 
DAAAVVDTLG DRFGINVADV GERGRLEARI DKVCFGAENR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. Cole S.T. Genome Res. 18:729-741(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-535 / M.
[2]	"Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site." Abuhammad A.M., Lowe E.D., Fullam E., Noble M., Garman E.F., Sim E. Protein Cell 1:384-392(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
[3]	"Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages." Abuhammad A., Fullam E., Lowe E.D., Staunton D., Kawamura A., Westwood I.M., Bhakta S., Garner A.C., Wilson D.L., Seden P.T., Davies S.G., Russell A.J., Garman E.F., Sim E. PLoS ONE 7:e52790-e52790(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000854 Genomic DNA. Translation: ACC43459.1.

RefSeq

YP_001853314.1. NC_010612.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LTW	X-ray	2.10	A	1-280	[»]
4B55	X-ray	2.70	A	1-280	[»]

ModBase

Protein-protein interaction databases

STRING

216594.MMAR_5055.

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

ACC43459; ACC43459; MMAR_5055.

GeneID

KEGG

PATRIC

18071517. VBIMycMar75906_5415.

Organism-specific databases

CMR

Phylogenomic databases

eggNOG

HOGENOM

KO

OMA

ProtClustDB

Enzyme and pathway databases

BioCyc

MMAR216594:GJOB-5097-MONOMER.

Family and domain databases

InterPro

IPR001447. Arylamine_N-AcTrfase.
[Graphical view]

PANTHER

PTHR11786. PTHR11786. 1 hit.

Pfam

PF00797. Acetyltransf_2. 1 hit.
[Graphical view]

ProtoNet

Other

EvolutionaryTrace

Entry information

Entry name

B2HIZ6_MYCMM

Accession

Primary (citable) accession number: B2HIZ6

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info