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B2HIZ6

- B2HIZ6_MYCMM

UniProt

B2HIZ6 - B2HIZ6_MYCMM

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Protein
Submitted name:

Arylamine N-acetyltransferase Nat

Gene

nat

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701CoenzymeAImported
Binding sitei97 – 971CoenzymeAImported
Binding sitei132 – 1321CoenzymeA; via amide nitrogenImported
Binding sitei152 – 1521CoenzymeAImported
Binding sitei220 – 2201CoenzymeAImported
Binding sitei229 – 2291CoenzymeAImported

GO - Molecular functioni

  1. acetyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-5097-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Arylamine N-acetyltransferase NatImported
Gene namesi
Name:natImported
Ordered Locus Names:MMAR_5055Imported
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)Imported
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_5055.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VFBX-ray2.00A1-280[»]
2VFCX-ray2.70A/B1-280[»]
3LTWX-ray2.10A1-280[»]
4B55X-ray2.70A1-280[»]
4C5PX-ray1.59A1-280[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB2HIZ6.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2162.
HOGENOMiHOG000205436.
KOiK00622.
OMAiPATHTLM.
OrthoDBiEOG6D2KV2.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HIZ6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALDLTGYLD RINYRGATDP TLDVLRDLVS AHTGAIAFEN LDPLMGVPVD
60 70 80 90 100
DLSAEALADK LVDRRRGGYC YEHNGLIGYV LAELGYRVRR LAGRVVWLAP
110 120 130 140 150
PDAPTPAQTH TVLAVTFPGC QGPYLVDVGF GGMTPTAPLR LETGTVQQTA
160 170 180 190 200
LEPYRLDDRG DGLVLQAMVR DEWQALYEFS TLTRPQVDLR VGSWFVSTHP
210 220 230 240 250
TSHFVTGLMA ATVADDARWN LMGRNLAIHR RGGTEKILLE DAAAVVDTLG
260 270 280
DRFGINVADV GERGRLEARI DKVCFGAENR
Length:280
Mass (Da):30,635
Last modified:June 10, 2008 - v1
Checksum:i7A8CBC3B199A1B91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC43459.1.
RefSeqiWP_012396579.1. NC_010612.1.
YP_001853314.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC43459; ACC43459; MMAR_5055.
GeneIDi6229346.
KEGGimmi:MMAR_5055.
PATRICi18071517. VBIMycMar75906_5415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC43459.1 .
RefSeqi WP_012396579.1. NC_010612.1.
YP_001853314.1. NC_010612.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VFB X-ray 2.00 A 1-280 [» ]
2VFC X-ray 2.70 A/B 1-280 [» ]
3LTW X-ray 2.10 A 1-280 [» ]
4B55 X-ray 2.70 A 1-280 [» ]
4C5P X-ray 1.59 A 1-280 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216594.MMAR_5055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC43459 ; ACC43459 ; MMAR_5055 .
GeneIDi 6229346.
KEGGi mmi:MMAR_5055.
PATRICi 18071517. VBIMycMar75906_5415.

Phylogenomic databases

eggNOGi COG2162.
HOGENOMi HOG000205436.
KOi K00622.
OMAi PATHTLM.
OrthoDBi EOG6D2KV2.

Enzyme and pathway databases

BioCyci MMAR216594:GJOB-5097-MONOMER.

Miscellaneous databases

EvolutionaryTracei B2HIZ6.

Family and domain databases

InterProi IPR001447. Arylamine_N-AcTrfase.
[Graphical view ]
PANTHERi PTHR11786. PTHR11786. 1 hit.
Pfami PF00797. Acetyltransf_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / MImported.
  2. "Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase."
    Fullam E., Westwood I.M., Anderton M.C., Lowe E.D., Sim E., Noble M.E.
    J. Mol. Biol. 375:178-191(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH COENZYMEA.
  3. "Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site."
    Abuhammad A.M., Lowe E.D., Fullam E., Noble M., Garman E.F., Sim E.
    Protein Cell 1:384-392(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  4. "Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages."
    Abuhammad A., Fullam E., Lowe E.D., Staunton D., Kawamura A., Westwood I.M., Bhakta S., Garner A.C., Wilson D.L., Seden P.T., Davies S.G., Russell A.J., Garman E.F., Sim E.
    PLoS ONE 7:e52790-e52790(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS).
  5. "Arylamine N-Acetyltransferases from Mycobacteria: Investigations of a Potential Target for Anti- Tubercular Therapy."
    Abuhammad A.
    Submitted (SEP-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS).

Entry informationi

Entry nameiB2HIZ6_MYCMM
AccessioniPrimary (citable) accession number: B2HIZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3