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B2HIA2

- SYL_MYCMM

UniProt

B2HIA2 - SYL_MYCMM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei748 – 7481ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-60-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MMAR_0057
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 976976Leucine--tRNA ligasePRO_1000091336Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_0057.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi86 – 9712"HIGH" regionAdd
    BLAST
    Motifi745 – 7495"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2HIA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTESPTTTPG STSGAPSGVP SGVNDAESDA PRHRYTAELA AGVERTWQQN    50
    WARLGTFNVP NPVGSLAPSD GSPVPEDKLF VQDMFPYPSG EGLHVGHPLG 100
    YIATDVFARY HRMKGRNVLH ALGFDAFGLP AEQYAVQTGT HPRTRTEANV 150
    VNFRRQLGRL GLGHDSRRSF STTDVEFYKW TQWIFLQIYN AWFDAAANKA 200
    RPISELVAEF DSGARSLVDG RDWSTLSAGE RADVIDDHRL VYRADSMVNW 250
    CPGLGTVLAN EEVTSDGRSD RGNFPVFRKR LRQWMMRITA YSDRLLDDLD 300
    VLDWPDQVKT MQRNWIGRST GASALFTATR SNGETVGLEV FTTRPDTLFG 350
    ATYLVLAPEH DLVDDLVGAG WPAGVDPLWT GGGATPAEAV AAYRRAIAAK 400
    SDLERQESKE KTGVFLGSHA INPATGQPVP IFIADYVLAG YGTGAIMAVP 450
    GHDQRDWDFA RALGLPVVEV IAGGDISQAA YTGDGVLVNS GFLDGMSVGE 500
    AKQAITARLE SDGHGQARIE FKLRDWLFAR QRYWGEPFPI VYDADGRPHA 550
    LDESALPVEL PDVPDYSPVL FDPDDANSEP SPPLGKATEW VHVELDLGDG 600
    LKPYSRDTNV MPQWAGSSWY ELRYTDPHNA DRFCAKENET YWMGPRPAEH 650
    GPDDPGGVDL YVGGAEHAVL HLLYARFWHK VLYDLGHVSS REPYRKLINQ 700
    GYIQAFAYTD ARGSYVPAEE VIERDGGFVY PGADGEIEVF QEFGKIGKSL 750
    KNSISPDEIC DDYGADTLRV YEMSMGPIEA SRPWATKDVI GAYRFLQRVW 800
    RLVIDENTGE ILVADTPAEL DTDTLRALHR AIAGVAEDYA ALRNNTAVAK 850
    LIEYTNFLTK RHRDAVPRAA IEPLVLMVAP LAPHLAEELW QRLGHTTSLA 900
    HGPFPAADPA YLIDDTVEYP VQVNGKVRGR VVVAADADDD AVKAAALADE 950
    KVQAFLAGAS PRKVIVVAGR LVNLVV 976
    Length:976
    Mass (Da):107,116
    Last modified:June 10, 2008 - v1
    Checksum:i3848111BF66E48F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC38528.1.
    RefSeqiYP_001848383.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC38528; ACC38528; MMAR_0057.
    GeneIDi6224275.
    KEGGimmi:MMAR_0057.
    PATRICi18060791. VBIMycMar75906_0089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC38528.1 .
    RefSeqi YP_001848383.1. NC_010612.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_0057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC38528 ; ACC38528 ; MMAR_0057 .
    GeneIDi 6224275.
    KEGGi mmi:MMAR_0057.
    PATRICi 18060791. VBIMycMar75906_0089.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MMAR216594:GJOB-60-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / M.

    Entry informationi

    Entry nameiSYL_MYCMM
    AccessioniPrimary (citable) accession number: B2HIA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3