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B2HI51 (B2HI51_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL ACC38477.1
Ordered Locus Names:MMAR_0006
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length839 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
B2HI51 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: FCB1D26CB71432FA

FASTA83992,785
        10         20         30         40         50         60 
MTDTTLPPGG EASDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM 

        70         80         90        100        110        120 
YDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP 

       130        140        150        160        170        180 
GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG 

       190        200        210        220        230        240 
GIAVGMATNI PPHNLRELAE AVFWCLENHD ADEEATLAAV TERVKGPDFP TSGLIVGTQG 

       250        260        270        280        290        300 
ISDAYKTGRG SIRMRGVVEI EEDSRGRTSL VITELPYQVN HDNFITSIAE QVRDGKLAGI 

       310        320        330        340        350        360 
SNIEDQSSDR VGLRIVVEIK RDAVAKVVLN NLYKHTQLQT SFGANMLSIV DGVPRTLRLD 

       370        380        390        400        410        420 
QMIRYYVEHQ LDVIIRRTTY RLRKANERAH ILRGLVKALD ALDEVIALIR ASQTVDIARV 

       430        440        450        460        470        480 
GLIELLDIDE IQAQAILDMQ LRRLAALERQ RIVDDLAKIE AEIADLEDIL AKPERQRAIV 

       490        500        510        520        530        540 
RDELAEIVDK HGDDRRTRII AADGEVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR 

       550        560        570        580        590        600 
GGKGVQGAGL KQDDIVRHFF VCSTHDWILF FTTQGRVYRA KAYELPEALR TARGQHVANL 

       610        620        630        640        650        660 
LAFQPEERIA QVIQIKSYED APYLVLATQN GLVKKSKLTD FDSNRSGGIV AINLRGEDEL 

       670        680        690        700        710        720 
VGAVLCSSEE DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD RLLSLNVVRE 

       730        740        750        760        770        780 
GTYLLVATAG GYAKRTGIEE YPVQGRGGKG VLTIMYDRRR GRLVGALIVD DDSELYAITS 

       790        800        810        820        830 
GGGVIRTAAR QVRKAGRQTK GVRLMNLGEG DTLLAIARNA EENADEAVAE ATDTDESSN

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC38477.1.
RefSeqYP_001848332.1. NC_010612.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2HI51.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000035999; EBMYCP00000034439; EBMYCG00000035994.
GeneID6224530.
GenomeReviewsGene locus MMAR_0006 in contig CP000854_GR.
KEGGmmi:MMAR_0006.
PATRIC18060679. VBIMycMar75906_0036.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016653.
HOGENOMHBG635183.
OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2HI51_MYCMM
AccessionPrimary (citable) accession number: B2HI51
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info