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B2HI05

- FAC19_MYCMM

UniProt

B2HI05 - FAC19_MYCMM

Protein

Long-chain-fatty-acid--CoA ligase FadD19

Gene

fadD19_1

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-5043-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase FadD19 (EC:6.2.1.3)
    Short name:
    FACL
    Alternative name(s):
    Acyl-CoA synthetase
    Gene namesi
    Name:fadD19_1
    Ordered Locus Names:MMAR_5001
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Long-chain-fatty-acid--CoA ligase FadD19PRO_0000406792Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_5001.

    Structurei

    3D structure databases

    ProteinModelPortaliB2HI05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000230015.
    KOiK00666.
    OMAiYRYVENE.
    OrthoDBiEOG6MSRZN.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2HI05-1 [UniParc]FASTAAdd to Basket

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    MAVALNIADL AEHAIDAVPD RVALICGDEQ LTYAQLEEKA NRLAHHLIDQ    50
    GVGKGDKVGL YCRNRIEIVI AMLGIIKAGA ILINVNFRYV EGELKYLFDN 100
    SDMVALVHER QYADRVANVL PDTPNVKTIL VVQDGSDKDY RRYGGVEFYS 150
    AIADSSPERD FAELQRERSA DDIYILYTGG TTGFPKGVMW RHEDIYRVLF 200
    GGTDFATGEF IKDEYDLAKA AAANPPMIRY PIPPMIHGAT QSATWMSIFS 250
    GQTTVLAPEF DADQVWRTIS DRKVNLLFFT GDAMARPLLD ALMKDNDYDL 300
    SSLFLLASTA ALFSPSIKEK LLELLPNRVI TDSIGSSETG FGGTSIVGAG 350
    QATTGGPRVT IDHRTVVLDE EGNEVKPGSG VRGIIAKKGN IPVGYYKDEK 400
    KTAETFKTIN GVRYAIPGDY AMVEADGTVT MLGRGSVSIN SGGEKIYPEE 450
    VEAALKGHPD VFDALVVGVP DPRYGQHVAA VVAPRPGSRP SLAELDGFVR 500
    SAIAGYKVPR SLWFVDEVKR SPAGKPDYRW AKEQTEARPA DDVHAAHVSA 550
    Length:550
    Mass (Da):59,946
    Last modified:June 10, 2008 - v1
    Checksum:i6BA317E6E7E31ACB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC43405.1.
    RefSeqiYP_001853260.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC43405; ACC43405; MMAR_5001.
    GeneIDi6229292.
    KEGGimmi:MMAR_5001.
    PATRICi18071407. VBIMycMar75906_5360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC43405.1 .
    RefSeqi YP_001853260.1. NC_010612.1.

    3D structure databases

    ProteinModelPortali B2HI05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_5001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC43405 ; ACC43405 ; MMAR_5001 .
    GeneIDi 6229292.
    KEGGi mmi:MMAR_5001.
    PATRICi 18071407. VBIMycMar75906_5360.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000230015.
    KOi K00666.
    OMAi YRYVENE.
    OrthoDBi EOG6MSRZN.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MMAR216594:GJOB-5043-MONOMER.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / M.

    Entry informationi

    Entry nameiFAC19_MYCMM
    AccessioniPrimary (citable) accession number: B2HI05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3