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B2HI05

- FAC19_MYCMM

UniProt

B2HI05 - FAC19_MYCMM

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Protein

Long-chain-fatty-acid--CoA ligase FadD19

Gene
fadD19_1, MMAR_5001
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-5043-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD19 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD19_1
Ordered Locus Names:MMAR_5001
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Long-chain-fatty-acid--CoA ligase FadD19PRO_0000406792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_5001.

Structurei

3D structure databases

ProteinModelPortaliB2HI05.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000230015.
KOiK00666.
OMAiYRYVENE.
OrthoDBiEOG6MSRZN.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HI05-1 [UniParc]FASTAAdd to Basket

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MAVALNIADL AEHAIDAVPD RVALICGDEQ LTYAQLEEKA NRLAHHLIDQ    50
GVGKGDKVGL YCRNRIEIVI AMLGIIKAGA ILINVNFRYV EGELKYLFDN 100
SDMVALVHER QYADRVANVL PDTPNVKTIL VVQDGSDKDY RRYGGVEFYS 150
AIADSSPERD FAELQRERSA DDIYILYTGG TTGFPKGVMW RHEDIYRVLF 200
GGTDFATGEF IKDEYDLAKA AAANPPMIRY PIPPMIHGAT QSATWMSIFS 250
GQTTVLAPEF DADQVWRTIS DRKVNLLFFT GDAMARPLLD ALMKDNDYDL 300
SSLFLLASTA ALFSPSIKEK LLELLPNRVI TDSIGSSETG FGGTSIVGAG 350
QATTGGPRVT IDHRTVVLDE EGNEVKPGSG VRGIIAKKGN IPVGYYKDEK 400
KTAETFKTIN GVRYAIPGDY AMVEADGTVT MLGRGSVSIN SGGEKIYPEE 450
VEAALKGHPD VFDALVVGVP DPRYGQHVAA VVAPRPGSRP SLAELDGFVR 500
SAIAGYKVPR SLWFVDEVKR SPAGKPDYRW AKEQTEARPA DDVHAAHVSA 550
Length:550
Mass (Da):59,946
Last modified:June 10, 2008 - v1
Checksum:i6BA317E6E7E31ACB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC43405.1.
RefSeqiYP_001853260.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC43405; ACC43405; MMAR_5001.
GeneIDi6229292.
KEGGimmi:MMAR_5001.
PATRICi18071407. VBIMycMar75906_5360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC43405.1 .
RefSeqi YP_001853260.1. NC_010612.1.

3D structure databases

ProteinModelPortali B2HI05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216594.MMAR_5001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC43405 ; ACC43405 ; MMAR_5001 .
GeneIDi 6229292.
KEGGi mmi:MMAR_5001.
PATRICi 18071407. VBIMycMar75906_5360.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000230015.
KOi K00666.
OMAi YRYVENE.
OrthoDBi EOG6MSRZN.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MMAR216594:GJOB-5043-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiFAC19_MYCMM
AccessioniPrimary (citable) accession number: B2HI05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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