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B2HHZ8

- FAC17_MYCMM

UniProt

B2HHZ8 - FAC17_MYCMM

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Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene

fadD17

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-5036-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD17
Ordered Locus Names:MMAR_4994
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Long-chain-fatty-acid--CoA ligase FadD17PRO_0000406789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_4994.

Structurei

3D structure databases

ProteinModelPortaliB2HHZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000052047.
KOiK00666.
OMAiKAVRCTH.
OrthoDBiEOG6VF30G.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HHZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSADPTVPQL LVPLAEIGDR GIYFEDSFTS WADHIGHGAA IAAALRERLD
60 70 80 90 100
PTRPPHVGVL LQNTPFFSAM LAAAGMSGII PVGLNPVRRG AALARDIEHA
110 120 130 140 150
DCQMVLADTA SASTLDGIEH VNVDSAEWAE VIDAHRNSEI SFQNAAPADL
160 170 180 190 200
FMLIYTSGTS GDPKAVKCSH SKVAIAGVTM TQRFGLGRDD VCYVSMPLFH
210 220 230 240 250
SNAVLVGWAV AVACQGSMAL RRKFSASQFL SDVRRYGATY ANYVGKPLSY
260 270 280 290 300
VLATPERPDD ADNPLRAVYG NEGVPGDSER FGCRFGCVVQ DGFGSTEGGV
310 320 330 340 350
AIARTPDTPA GSLGPLPENI EILDPETGQQ CPVGAVGELV NTAGPGRFEG
360 370 380 390 400
YYNDEAASAQ RMSGGVYHSG DLAYRDAAGY AYFAGRLGDW MRVDGENLGT
410 420 430 440 450
APIERVLLRY PDAIEVAVYA IPDPVVGDQV MAAMVLTPGA KFDVDKFRAF
460 470 480 490 500
LAGQSDLGPK QWPSYVRICS ALPRTETFKV LKRQLAADGV DCGDPVWPIR

DQS
Length:503
Mass (Da):53,652
Last modified:June 10, 2008 - v1
Checksum:iAE37B92E9C5024F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC43398.1.
RefSeqiWP_012396518.1. NC_010612.1.
YP_001853253.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC43398; ACC43398; MMAR_4994.
GeneIDi6229285.
KEGGimmi:MMAR_4994.
PATRICi18071383. VBIMycMar75906_5348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC43398.1 .
RefSeqi WP_012396518.1. NC_010612.1.
YP_001853253.1. NC_010612.1.

3D structure databases

ProteinModelPortali B2HHZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216594.MMAR_4994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC43398 ; ACC43398 ; MMAR_4994 .
GeneIDi 6229285.
KEGGi mmi:MMAR_4994.
PATRICi 18071383. VBIMycMar75906_5348.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000052047.
KOi K00666.
OMAi KAVRCTH.
OrthoDBi EOG6VF30G.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MMAR216594:GJOB-5036-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiFAC17_MYCMM
AccessioniPrimary (citable) accession number: B2HHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3