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B2HHZ8

- FAC17_MYCMM

UniProt

B2HHZ8 - FAC17_MYCMM

Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene

fadD17

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-5036-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
    Short name:
    FACL
    Alternative name(s):
    Acyl-CoA synthetase
    Gene namesi
    Name:fadD17
    Ordered Locus Names:MMAR_4994
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Long-chain-fatty-acid--CoA ligase FadD17PRO_0000406789Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_4994.

    Structurei

    3D structure databases

    ProteinModelPortaliB2HHZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000052047.
    KOiK00666.
    OMAiKAVRCTH.
    OrthoDBiEOG6VF30G.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2HHZ8-1 [UniParc]FASTAAdd to Basket

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    MSADPTVPQL LVPLAEIGDR GIYFEDSFTS WADHIGHGAA IAAALRERLD    50
    PTRPPHVGVL LQNTPFFSAM LAAAGMSGII PVGLNPVRRG AALARDIEHA 100
    DCQMVLADTA SASTLDGIEH VNVDSAEWAE VIDAHRNSEI SFQNAAPADL 150
    FMLIYTSGTS GDPKAVKCSH SKVAIAGVTM TQRFGLGRDD VCYVSMPLFH 200
    SNAVLVGWAV AVACQGSMAL RRKFSASQFL SDVRRYGATY ANYVGKPLSY 250
    VLATPERPDD ADNPLRAVYG NEGVPGDSER FGCRFGCVVQ DGFGSTEGGV 300
    AIARTPDTPA GSLGPLPENI EILDPETGQQ CPVGAVGELV NTAGPGRFEG 350
    YYNDEAASAQ RMSGGVYHSG DLAYRDAAGY AYFAGRLGDW MRVDGENLGT 400
    APIERVLLRY PDAIEVAVYA IPDPVVGDQV MAAMVLTPGA KFDVDKFRAF 450
    LAGQSDLGPK QWPSYVRICS ALPRTETFKV LKRQLAADGV DCGDPVWPIR 500
    DQS 503
    Length:503
    Mass (Da):53,652
    Last modified:June 10, 2008 - v1
    Checksum:iAE37B92E9C5024F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC43398.1.
    RefSeqiWP_012396518.1. NC_010612.1.
    YP_001853253.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC43398; ACC43398; MMAR_4994.
    GeneIDi6229285.
    KEGGimmi:MMAR_4994.
    PATRICi18071383. VBIMycMar75906_5348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC43398.1 .
    RefSeqi WP_012396518.1. NC_010612.1.
    YP_001853253.1. NC_010612.1.

    3D structure databases

    ProteinModelPortali B2HHZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_4994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC43398 ; ACC43398 ; MMAR_4994 .
    GeneIDi 6229285.
    KEGGi mmi:MMAR_4994.
    PATRICi 18071383. VBIMycMar75906_5348.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000052047.
    KOi K00666.
    OMAi KAVRCTH.
    OrthoDBi EOG6VF30G.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MMAR216594:GJOB-5036-MONOMER.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / M.

    Entry informationi

    Entry nameiFAC17_MYCMM
    AccessioniPrimary (citable) accession number: B2HHZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3