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Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene

fadD17

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD17
Ordered Locus Names:MMAR_4994
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004067891 – 503Long-chain-fatty-acid--CoA ligase FadD17Add BLAST503

Proteomic databases

PRIDEiB2HHZ8

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_4994

Structurei

3D structure databases

ProteinModelPortaliB2HHZ8
SMRiB2HHZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105J5T Bacteria
COG0318 LUCA
HOGENOMiHOG000052047
KOiK00666
OMAiPKQWPSY
OrthoDBiPOG091H02SZ

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030310 FadD17
PANTHERiPTHR43107:SF15 PTHR43107:SF15, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

B2HHZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADPTVPQL LVPLAEIGDR GIYFEDSFTS WADHIGHGAA IAAALRERLD
60 70 80 90 100
PTRPPHVGVL LQNTPFFSAM LAAAGMSGII PVGLNPVRRG AALARDIEHA
110 120 130 140 150
DCQMVLADTA SASTLDGIEH VNVDSAEWAE VIDAHRNSEI SFQNAAPADL
160 170 180 190 200
FMLIYTSGTS GDPKAVKCSH SKVAIAGVTM TQRFGLGRDD VCYVSMPLFH
210 220 230 240 250
SNAVLVGWAV AVACQGSMAL RRKFSASQFL SDVRRYGATY ANYVGKPLSY
260 270 280 290 300
VLATPERPDD ADNPLRAVYG NEGVPGDSER FGCRFGCVVQ DGFGSTEGGV
310 320 330 340 350
AIARTPDTPA GSLGPLPENI EILDPETGQQ CPVGAVGELV NTAGPGRFEG
360 370 380 390 400
YYNDEAASAQ RMSGGVYHSG DLAYRDAAGY AYFAGRLGDW MRVDGENLGT
410 420 430 440 450
APIERVLLRY PDAIEVAVYA IPDPVVGDQV MAAMVLTPGA KFDVDKFRAF
460 470 480 490 500
LAGQSDLGPK QWPSYVRICS ALPRTETFKV LKRQLAADGV DCGDPVWPIR

DQS
Length:503
Mass (Da):53,652
Last modified:June 10, 2008 - v1
Checksum:iAE37B92E9C5024F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA Translation: ACC43398.1
RefSeqiWP_012396518.1, NC_010612.1

Genome annotation databases

EnsemblBacteriaiACC43398; ACC43398; MMAR_4994
KEGGimmi:MMAR_4994

Similar proteinsi

Entry informationi

Entry nameiFAC17_MYCMM
AccessioniPrimary (citable) accession number: B2HHZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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