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B2HHZ8 (FAC17_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase FadD17

Short name=FACL
EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase
Gene names
Name:fadD17
Ordered Locus Names:MMAR_4994
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Long-chain-fatty-acid--CoA ligase FadD17
PRO_0000406789

Sequences

Sequence LengthMass (Da)Tools
B2HHZ8 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: AE37B92E9C5024F3

FASTA50353,652
        10         20         30         40         50         60 
MSADPTVPQL LVPLAEIGDR GIYFEDSFTS WADHIGHGAA IAAALRERLD PTRPPHVGVL 

        70         80         90        100        110        120 
LQNTPFFSAM LAAAGMSGII PVGLNPVRRG AALARDIEHA DCQMVLADTA SASTLDGIEH 

       130        140        150        160        170        180 
VNVDSAEWAE VIDAHRNSEI SFQNAAPADL FMLIYTSGTS GDPKAVKCSH SKVAIAGVTM 

       190        200        210        220        230        240 
TQRFGLGRDD VCYVSMPLFH SNAVLVGWAV AVACQGSMAL RRKFSASQFL SDVRRYGATY 

       250        260        270        280        290        300 
ANYVGKPLSY VLATPERPDD ADNPLRAVYG NEGVPGDSER FGCRFGCVVQ DGFGSTEGGV 

       310        320        330        340        350        360 
AIARTPDTPA GSLGPLPENI EILDPETGQQ CPVGAVGELV NTAGPGRFEG YYNDEAASAQ 

       370        380        390        400        410        420 
RMSGGVYHSG DLAYRDAAGY AYFAGRLGDW MRVDGENLGT APIERVLLRY PDAIEVAVYA 

       430        440        450        460        470        480 
IPDPVVGDQV MAAMVLTPGA KFDVDKFRAF LAGQSDLGPK QWPSYVRICS ALPRTETFKV 

       490        500 
LKRQLAADGV DCGDPVWPIR DQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000854 Genomic DNA. Translation: ACC43398.1.
RefSeqYP_001853253.1. NC_010612.1.

3D structure databases

ProteinModelPortalB2HHZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216594.MMAR_4994.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC43398; ACC43398; MMAR_4994.
GeneID6229285.
KEGGmmi:MMAR_4994.
PATRIC18071383. VBIMycMar75906_5348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0318.
HOGENOMHOG000052047.
KOK00666.
OMAKAVRCTH.
OrthoDBEOG6VF30G.

Enzyme and pathway databases

BioCycMMAR216594:GJOB-5036-MONOMER.
UniPathwayUPA00094.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAC17_MYCMM
AccessionPrimary (citable) accession number: B2HHZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways