Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene

fadD17

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway:ifatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-5036-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD17
Ordered Locus Names:MMAR_4994
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Long-chain-fatty-acid--CoA ligase FadD17PRO_0000406789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_4994.

Structurei

3D structure databases

ProteinModelPortaliB2HHZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000052047.
KOiK00666.
OMAiKAVRCTH.
OrthoDBiEOG6VF30G.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030310. FadD17.
[Graphical view]
PANTHERiPTHR24096:SF115. PTHR24096:SF115. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HHZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADPTVPQL LVPLAEIGDR GIYFEDSFTS WADHIGHGAA IAAALRERLD
60 70 80 90 100
PTRPPHVGVL LQNTPFFSAM LAAAGMSGII PVGLNPVRRG AALARDIEHA
110 120 130 140 150
DCQMVLADTA SASTLDGIEH VNVDSAEWAE VIDAHRNSEI SFQNAAPADL
160 170 180 190 200
FMLIYTSGTS GDPKAVKCSH SKVAIAGVTM TQRFGLGRDD VCYVSMPLFH
210 220 230 240 250
SNAVLVGWAV AVACQGSMAL RRKFSASQFL SDVRRYGATY ANYVGKPLSY
260 270 280 290 300
VLATPERPDD ADNPLRAVYG NEGVPGDSER FGCRFGCVVQ DGFGSTEGGV
310 320 330 340 350
AIARTPDTPA GSLGPLPENI EILDPETGQQ CPVGAVGELV NTAGPGRFEG
360 370 380 390 400
YYNDEAASAQ RMSGGVYHSG DLAYRDAAGY AYFAGRLGDW MRVDGENLGT
410 420 430 440 450
APIERVLLRY PDAIEVAVYA IPDPVVGDQV MAAMVLTPGA KFDVDKFRAF
460 470 480 490 500
LAGQSDLGPK QWPSYVRICS ALPRTETFKV LKRQLAADGV DCGDPVWPIR

DQS
Length:503
Mass (Da):53,652
Last modified:June 10, 2008 - v1
Checksum:iAE37B92E9C5024F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC43398.1.
RefSeqiWP_012396518.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC43398; ACC43398; MMAR_4994.
KEGGimmi:MMAR_4994.
PATRICi18071383. VBIMycMar75906_5348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC43398.1.
RefSeqiWP_012396518.1. NC_010612.1.

3D structure databases

ProteinModelPortaliB2HHZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_4994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC43398; ACC43398; MMAR_4994.
KEGGimmi:MMAR_4994.
PATRICi18071383. VBIMycMar75906_5348.

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000052047.
KOiK00666.
OMAiKAVRCTH.
OrthoDBiEOG6VF30G.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciMMAR216594:GJOB-5036-MONOMER.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030310. FadD17.
[Graphical view]
PANTHERiPTHR24096:SF115. PTHR24096:SF115. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiFAC17_MYCMM
AccessioniPrimary (citable) accession number: B2HHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: July 22, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.