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B2HHZ8

- FAC17_MYCMM

UniProt

B2HHZ8 - FAC17_MYCMM

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Protein
Long-chain-fatty-acid--CoA ligase FadD17
Gene
fadD17, MMAR_4994
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-5036-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD17
Ordered Locus Names:MMAR_4994
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Long-chain-fatty-acid--CoA ligase FadD17
PRO_0000406789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_4994.

Structurei

3D structure databases

ProteinModelPortaliB2HHZ8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000052047.
KOiK00666.
OMAiKAVRCTH.
OrthoDBiEOG6VF30G.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HHZ8-1 [UniParc]FASTAAdd to Basket

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MSADPTVPQL LVPLAEIGDR GIYFEDSFTS WADHIGHGAA IAAALRERLD    50
PTRPPHVGVL LQNTPFFSAM LAAAGMSGII PVGLNPVRRG AALARDIEHA 100
DCQMVLADTA SASTLDGIEH VNVDSAEWAE VIDAHRNSEI SFQNAAPADL 150
FMLIYTSGTS GDPKAVKCSH SKVAIAGVTM TQRFGLGRDD VCYVSMPLFH 200
SNAVLVGWAV AVACQGSMAL RRKFSASQFL SDVRRYGATY ANYVGKPLSY 250
VLATPERPDD ADNPLRAVYG NEGVPGDSER FGCRFGCVVQ DGFGSTEGGV 300
AIARTPDTPA GSLGPLPENI EILDPETGQQ CPVGAVGELV NTAGPGRFEG 350
YYNDEAASAQ RMSGGVYHSG DLAYRDAAGY AYFAGRLGDW MRVDGENLGT 400
APIERVLLRY PDAIEVAVYA IPDPVVGDQV MAAMVLTPGA KFDVDKFRAF 450
LAGQSDLGPK QWPSYVRICS ALPRTETFKV LKRQLAADGV DCGDPVWPIR 500
DQS 503
Length:503
Mass (Da):53,652
Last modified:June 10, 2008 - v1
Checksum:iAE37B92E9C5024F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC43398.1.
RefSeqiWP_012396518.1. NC_010612.1.
YP_001853253.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC43398; ACC43398; MMAR_4994.
GeneIDi6229285.
KEGGimmi:MMAR_4994.
PATRICi18071383. VBIMycMar75906_5348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC43398.1 .
RefSeqi WP_012396518.1. NC_010612.1.
YP_001853253.1. NC_010612.1.

3D structure databases

ProteinModelPortali B2HHZ8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 216594.MMAR_4994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC43398 ; ACC43398 ; MMAR_4994 .
GeneIDi 6229285.
KEGGi mmi:MMAR_4994.
PATRICi 18071383. VBIMycMar75906_5348.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000052047.
KOi K00666.
OMAi KAVRCTH.
OrthoDBi EOG6VF30G.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MMAR216594:GJOB-5036-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiFAC17_MYCMM
AccessioniPrimary (citable) accession number: B2HHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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