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B2HHR2 (B2HHR2_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL ACC41760.1
Ordered Locus Names:MMAR_3334
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length929 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
B2HHR2 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 14244E526FF4C4F7

FASTA929103,335
        10         20         30         40         50         60 
MTTEFVRHDL AKTSSSASEP DRVRVIREGV ASYLPDIDPE ETSEWLESFD ALLEHSGPAR 

        70         80         90        100        110        120 
ARYLMLRLLE RAGEQRVAIP SLTSTDYVNT IPTELEPWFP GDEDVERRYR TWIRWNAAIM 

       130        140        150        160        170        180 
VHRAQRPGVG VGGHISTYAS SAALYEVGFN HFFRGKSHPG GGDQVFIQGH ASPGIYARAF 

       190        200        210        220        230        240 
LEGRLSADQL DGFRQEHSHP GGGLPSYPHP RLMPDFWEFP TVSMGLGPLN AIYQARFNHY 

       250        260        270        280        290        300 
LHDRGIKDTS DQHVWCFLGD GEMDEPESRG LAHMGALEGL DNLTFVINCN LQRLDGPVRG 

       310        320        330        340        350        360 
NGKIIQELES FFRGAGWNVI KVVWGREWDA LLHADRDGAL VNLMNSTPDG DYQTYKANDG 

       370        380        390        400        410        420 
AYVRDHFFGR DPRTKALVAN MSDQEIWNLK RGGHDYRKVY AAYRAAVDHK GQPTVILAKT 

       430        440        450        460        470        480 
IKGYSLGAHF QGRNATHQMK KLALADLKRF RDSMRIPVSD AQLDEDPYLP PYYHPGSDAP 

       490        500        510        520        530        540 
EIRYMLDRRR TLGGFLPERP TKAKTLTLPG PDAYKVLKKG SGQQEVATTM ALVRTFKELL 

       550        560        570        580        590        600 
RDKNIGNRIV PIIPDEARTF GMDSWFPSLK IYNRNGQLYT AVDAELMLAY KESHVGQILH 

       610        620        630        640        650        660 
EGINEAGSVG SFTAAGTSYA THNEPMIPIY IFYSMFGFQR TGDSFWAAAD QMARGFVLGA 

       670        680        690        700        710        720 
TAGRTTLTGE GLQHADGHSL LLAATNPAVV SYDPAFAYEL AYIIENGLSR MFGENPENIY 

       730        740        750        760        770        780 
FYITVYNEPY VQPAEPENFD PEGVLRGMYR YRAATKQCAH KAQLLASGVS MPDALKAAQM 

       790        800        810        820        830        840 
LADEWDVATD VWSVTSWSEL NRDGVSVERH RLRHPGEPAG VAYVTTALEG TSGPVVAVSD 

       850        860        870        880        890        900 
WMRAVPEQIR PWVPGTYVTL GTDGFGFSDT RPAARRYFNT DAESQVVAVL EALARDGEID 

       910        920 
ESVAVTAARQ YRIDDVQAAP KQTSDSGVA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC41760.1.
RefSeqYP_001851615.1. NC_010612.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2HHR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000032896; EBMYCP00000031336; EBMYCG00000032891.
GeneID6227604.
GenomeReviewsGene locus MMAR_3334 in contig CP000854_GR.
KEGGmmi:MMAR_3334.
PATRIC18067783. VBIMycMar75906_3570.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016271.
HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2HHR2_MYCMM
AccessionPrimary (citable) accession number: B2HHR2
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info