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Protein

Glutamate-ammonia-ligase adenylyltransferase

Gene

glnE

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adenylation and deadenylation of glutamate--ammonia ligase.UniRule annotation

Catalytic activityi

ATP + [L-glutamate:ammonia ligase (ADP-forming)]-L-tyrosine = diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-O(4)-(5'-adenylyl)-L-tyrosine.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-3312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-ammonia-ligase adenylyltransferaseUniRule annotation (EC:2.7.7.42UniRule annotation)
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name:
ATaseUniRule annotation
[Glutamate--ammonia-ligase] adenylyltransferaseUniRule annotation
Gene namesi
Name:glnEUniRule annotation
Ordered Locus Names:MMAR_3293
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995Glutamate-ammonia-ligase adenylyltransferasePRO_1000133908Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_3293.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 341192GlnE 1Add
BLAST
Regioni646 – 853208GlnE 2Add
BLAST

Sequence similaritiesi

Belongs to the GlnE family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
HOGENOMiHOG000243040.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiEOG651SRZ.

Family and domain databases

HAMAPiMF_00802. GlnE.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HHM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTKPATQR PKLPSVGRLG LVDALAGARL AELGWTEHDD QAHVDLLWSL
60 70 80 90 100
SRAPDADAAL KVLVRLAENP DTGWDELNAA LLNERSLRGR LFAVLGSSLS
110 120 130 140 150
LGDHLVANPQ SWKLLRGKVA LPSHAALLES FVDLAEEVAA APASAVHRLR
160 170 180 190 200
ALHRDHVLVL AGLDLAATVE DEPVLPFTVV AAHLADIADA ALAAALRLAE
210 220 230 240 250
KTVCRDRTPP RLAVIAMGKC GARELNYVSD VDVIFVAERA DPISIRVAGE
260 270 280 290 300
MMRVASSTFF EVDAGLRPEG RSGELVRTVE SHIAYYQRWA KTWEFQALLK
310 320 330 340 350
ARAAVGDAEL GQSYLAALMP MVWTACERDD FVAEVQAMRR RVEQLVPADI
360 370 380 390 400
RGRELKLGTG GLRDVEFVAQ LLQLVHGRSD ESLHVASTVD ALSALGEGGY
410 420 430 440 450
IGREDAANMI ASYEFLRLLE HRLQLQRLKR THLLPEFDDE EAVRWLARAA
460 470 480 490 500
HIRPDGRHDA AGMLREELKH QNVRVSRLHA KLFYQPLLES IAPAGLEIAG
510 520 530 540 550
RGMTSEAAER QLAALGYEGP QTALKHMAAL VNHSGRRARV QSVLLPRLLD
560 570 580 590 600
WLSYAPDPDG GLLAYRRLSE ALATQSWYLS TLRDKPTVGR RLMHVLGTSA
610 620 630 640 650
FVPDLLMRAP EVIQNYGDGR TGPKLLETEP AAVARALIAS AGRYSDPLRA
660 670 680 690 700
IAAARTLRRR ELARIGSADL LGLLEVTEVC RALTSVWVAV LQSALEAMIR
710 720 730 740 750
ANTPEGGRPL ARIAVIGMGR LGGSELSYGS DADVMYVCEP ASGVTDAQAV
760 770 780 790 800
KWSTAVAEQV RAKLGTPSVD PPLEVDANLR PEGRNGPLVR TLASYEAYYA
810 820 830 840 850
QWAQAWEIQA LLRAHAVAGD AELGQRFLLL VDHTRYPPDG VSAEAVHEIR
860 870 880 890 900
RIKARVESER LPRGADPNTH TKLGRGGLAD IEWTVQLLQL QNAHEIEALH
910 920 930 940 950
NTSTLESLDA IAEAKLVAED EVKLLRQAWL TATRARNALV LVRGKPTDQL
960 970 980 990
PGPGRQLNAV AVAAGWHNDD GGEFLDNYLR VTRRAKAVVR KVFGS
Length:995
Mass (Da):108,542
Last modified:June 10, 2008 - v1
Checksum:iF3FF5B4E2D5AC3FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC41719.1.
RefSeqiWP_012394947.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC41719; ACC41719; MMAR_3293.
KEGGimmi:MMAR_3293.
PATRICi18067697. VBIMycMar75906_3528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC41719.1.
RefSeqiWP_012394947.1. NC_010612.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_3293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC41719; ACC41719; MMAR_3293.
KEGGimmi:MMAR_3293.
PATRICi18067697. VBIMycMar75906_3528.

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
HOGENOMiHOG000243040.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiEOG651SRZ.

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-3312-MONOMER.

Family and domain databases

HAMAPiMF_00802. GlnE.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiGLNE_MYCMM
AccessioniPrimary (citable) accession number: B2HHM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: November 11, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.