B2HH29 (B2HH29_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Name:	purM EMBL ACC43284.1
Ordered Locus Names:	MMAR_4880

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HH29 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 1B326563980F560E	FASTA	367	38,664
	10 20 30 40 50 60 MTDPEKSPES SGRGPASQGV TYAAAGVDIE AGDRAVELFK PLATRATRPE VRGGLGGFAG 70 80 90 100 110 120 LFALRNDYRE PVLAASTDGV GTKLAVAQAM DKHDTVGLDL VAMVVDDLVV CGAEPLFLQD 130 140 150 160 170 180 YIAVGRTVPE RVSAIVSGIA EGCVRAGCAL LGGETAEHPG LMAPDHYDIS ATGVGVVEAD 190 200 210 220 230 240 DVLGPERVKP GDVIIAMGSS GLHSNGYSLA RNVLLEIDRM NLAGYVEEFG RTLGEELLEP 250 260 270 280 290 300 TRIYAKDCLA LTAETHVRTF CHVTGGGLAG NLERVIPHGL VAEIDRGTWT PAPVFAMIAQ 310 320 330 340 350 360 RGRVVREEME KTFNMGVGMI AVVAPEDTDR ALAILTARHL DCWVLGTVCK GGKEGPRATL VGQHPRF

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC43284.1.
RefSeq	YP_001853139.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HH29.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HH29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000032553; EBMYCP00000030993; EBMYCG00000032548.
GeneID	6229170.
GenomeReviews	Gene locus MMAR_4880 in contig CP000854_GR.
KEGG	mmi:MMAR_4880.
PATRIC	18071149. VBIMycMar75906_5232.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2HH29_MYCMM

Accession

Primary (citable) accession number: B2HH29

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)