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B2HGV4

- FAC15_MYCMM

UniProt

B2HGV4 - FAC15_MYCMM

Protein

Long-chain-fatty-acid--CoA ligase FadD15

Gene

fadD15

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-3249-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase FadD15 (EC:6.2.1.3)
    Short name:
    FACL
    Alternative name(s):
    Acyl-CoA synthetase
    Gene namesi
    Name:fadD15
    Ordered Locus Names:MMAR_3231
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Long-chain-fatty-acid--CoA ligase FadD15PRO_0000406786Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_3231.

    Structurei

    3D structure databases

    ProteinModelPortaliB2HGV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    HOGENOMiHOG000229985.
    KOiK01897.
    OMAiAIYETSA.
    OrthoDBiEOG64FKGZ.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2HGV4-1 [UniParc]FASTAAdd to Basket

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    MRQYSVPARF SVDERDNVAA MVFEHERDDP DHIIYQRQID GIWTDITCAE    50
    AARHIRSAAL GLIALGVQAG DRVSIFSATC YEWAILDLAI LAVGAVTVPI 100
    YETSSAEQVR WVLQNSEAVL AFAETDAHAA MIAELTGDLP ALRRVLVING 150
    SGPKALEQLA EEGGSVDRAE LTARLDALRS SDPATLIYTS GTTGRPKGCQ 200
    LTHSNLLHEI RGTQECLPTL LTPGQRLLVF LPLAHVLARA LTLSAFASKV 250
    TVGFTSDIKN LLPLFAVFKP TVVVSVPRVF EKVYNTAEQN ASNDGKGAIF 300
    KLAAQTAVDW SRAWDDGRPG LLLRAKHALF DRLVYHKLRA ALGGDCHAAV 350
    SGGAPLGARL GHFYRGVGLT IYEGYGLTET SAAVTVNQID ALKIGTVGKL 400
    VPGNSLRIAD DGELLVRGGV VFSGYWRNEQ ATDEAFTDGW FRTGDLGAID 450
    DDGFLSITGR KKELIVTAGG KNVAPAVLED QLRAHPLISQ AMVVGDAKPF 500
    IGALITIDPE AFGGWKQRNS KADHAAVRDL AEDPDLVAEV DAAVKEANLA 550
    VSHAESIRKF RILHVDFTED TGELTPTMKV KRNVVAEKFS VEIEAIYTKD 600
    Length:600
    Mass (Da):64,751
    Last modified:June 10, 2008 - v1
    Checksum:iCB132BBBF2E36150
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC41657.1.
    RefSeqiYP_001851512.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC41657; ACC41657; MMAR_3231.
    GeneIDi6227498.
    KEGGimmi:MMAR_3231.
    PATRICi18067557. VBIMycMar75906_3458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC41657.1 .
    RefSeqi YP_001851512.1. NC_010612.1.

    3D structure databases

    ProteinModelPortali B2HGV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_3231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC41657 ; ACC41657 ; MMAR_3231 .
    GeneIDi 6227498.
    KEGGi mmi:MMAR_3231.
    PATRICi 18067557. VBIMycMar75906_3458.

    Phylogenomic databases

    eggNOGi COG1022.
    HOGENOMi HOG000229985.
    KOi K01897.
    OMAi AIYETSA.
    OrthoDBi EOG64FKGZ.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MMAR216594:GJOB-3249-MONOMER.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / M.

    Entry informationi

    Entry nameiFAC15_MYCMM
    AccessioniPrimary (citable) accession number: B2HGV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3