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B2HGV4 (FAC15_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase FadD15

Short name=FACL
EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase
Gene names
Name:fadD15
Ordered Locus Names:MMAR_3231
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Long-chain-fatty-acid--CoA ligase FadD15
PRO_0000406786

Sequences

Sequence LengthMass (Da)Tools
B2HGV4 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: CB132BBBF2E36150

FASTA60064,751
        10         20         30         40         50         60 
MRQYSVPARF SVDERDNVAA MVFEHERDDP DHIIYQRQID GIWTDITCAE AARHIRSAAL 

        70         80         90        100        110        120 
GLIALGVQAG DRVSIFSATC YEWAILDLAI LAVGAVTVPI YETSSAEQVR WVLQNSEAVL 

       130        140        150        160        170        180 
AFAETDAHAA MIAELTGDLP ALRRVLVING SGPKALEQLA EEGGSVDRAE LTARLDALRS 

       190        200        210        220        230        240 
SDPATLIYTS GTTGRPKGCQ LTHSNLLHEI RGTQECLPTL LTPGQRLLVF LPLAHVLARA 

       250        260        270        280        290        300 
LTLSAFASKV TVGFTSDIKN LLPLFAVFKP TVVVSVPRVF EKVYNTAEQN ASNDGKGAIF 

       310        320        330        340        350        360 
KLAAQTAVDW SRAWDDGRPG LLLRAKHALF DRLVYHKLRA ALGGDCHAAV SGGAPLGARL 

       370        380        390        400        410        420 
GHFYRGVGLT IYEGYGLTET SAAVTVNQID ALKIGTVGKL VPGNSLRIAD DGELLVRGGV 

       430        440        450        460        470        480 
VFSGYWRNEQ ATDEAFTDGW FRTGDLGAID DDGFLSITGR KKELIVTAGG KNVAPAVLED 

       490        500        510        520        530        540 
QLRAHPLISQ AMVVGDAKPF IGALITIDPE AFGGWKQRNS KADHAAVRDL AEDPDLVAEV 

       550        560        570        580        590        600 
DAAVKEANLA VSHAESIRKF RILHVDFTED TGELTPTMKV KRNVVAEKFS VEIEAIYTKD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000854 Genomic DNA. Translation: ACC41657.1.
RefSeqYP_001851512.1. NC_010612.1.

3D structure databases

ProteinModelPortalB2HGV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216594.MMAR_3231.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC41657; ACC41657; MMAR_3231.
GeneID6227498.
KEGGmmi:MMAR_3231.
PATRIC18067557. VBIMycMar75906_3458.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1022.
HOGENOMHOG000229985.
KOK01897.
OMAAIYETSA.
OrthoDBEOG64FKGZ.

Enzyme and pathway databases

BioCycMMAR216594:GJOB-3249-MONOMER.
UniPathwayUPA00094.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAC15_MYCMM
AccessionPrimary (citable) accession number: B2HGV4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways