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Protein

Acetaldehyde dehydrogenase 1

Gene

mhpF

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Acyl-thioester intermediateUniRule annotation1
Binding sitei309NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 35NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:MMAR_1505
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876771 – 336Acetaldehyde dehydrogenase 1Add BLAST336

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_1505.

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiPEFANIR.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B2HGH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGAADVGA GAGPPGQHAG AVDNWPVAII GSGVVGADLM SRIGNGDGRL
60 70 80 90 100
RVSAMVGTNP HCDGLARAAA AGISTSPGGV DGLLIMPEFA NIRLVFDTTN
110 120 130 140 150
PGARQSNWAR LADTGVRMLD LTASAIGPCC VPAVNLDAQL DAPNLSMATC
160 170 180 190 200
SAQAAVPIVA AVRRHGVVRY AEVVSAIASQ ALGPAERVTL DEFAELTTTA
210 220 230 240 250
VQELGGARRA KTLTIVNPAD PPMPMRTTVF CLVDQADEVA RIEADVLAVV
260 270 280 290 300
DGVQALLPGY RLKHRVQFER LGSGNTLYIP GTGEFGGTRI TVLLEITAAG
310 320 330
GYLPACAGNV AIVTSAAKAT AEAIVEHHAQ TVKAEL
Length:336
Mass (Da):34,340
Last modified:June 10, 2008 - v1
Checksum:iBF143065EFA89B7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39956.1.
RefSeqiWP_012393348.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC39956; ACC39956; MMAR_1505.
KEGGimmi:MMAR_1505.
PATRICi18063835. VBIMycMar75906_1605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39956.1.
RefSeqiWP_012393348.1. NC_010612.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_1505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC39956; ACC39956; MMAR_1505.
KEGGimmi:MMAR_1505.
PATRICi18063835. VBIMycMar75906_1605.

Phylogenomic databases

eggNOGiCOG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiPEFANIR.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDH1_MYCMM
AccessioniPrimary (citable) accession number: B2HGH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.