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B2HFY7 (UPPP_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:MMAR_3116
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197383

Regions

Transmembrane90 – 11021Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane256 – 27621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2HFY7 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: D2D732FB8BE00124

FASTA28230,307
        10         20         30         40         50         60 
MSAVAAMSWW QVISLAVVQG LTEFLPVSSS GHLAVVSRVF FSDDAGASFT AVTQLGTEAA 

        70         80         90        100        110        120 
VLVYFARDIV RILRAWFDGL VVTSHRNADY RLGWYVIIGT IPICVMGLLF KDEIRSGVRN 

       130        140        150        160        170        180 
LWVVATALVV FSGVIALAEY LGRQSRHVEQ LTWRDGLVVG VAQTLALVPG VSRSGSTISA 

       190        200        210        220        230        240 
GLFLGLDREL AARFGFLLAI PAVFASGLFS LPDAFHPVTE GMSATGPQLL VATLIAFVVG 

       250        260        270        280 
LAAVSWFLRF LLRHSMYWFV GYRVVVGVVV LILLATGTVA AT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000854 Genomic DNA. Translation: ACC41551.1.
RefSeqYP_001851406.1. NC_010612.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216594.MMAR_3116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC41551; ACC41551; MMAR_3116.
GeneID6227382.
KEGGmmi:MMAR_3116.
PATRIC18067305. VBIMycMar75906_3333.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycMMAR216594:GJOB-3133-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MYCMM
AccessionPrimary (citable) accession number: B2HFY7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families