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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei215SubstrateUniRule annotation1
Binding sitei245SubstrateUniRule annotation1
Binding sitei249SubstrateUniRule annotation1
Binding sitei250NADUniRule annotation1
Binding sitei302NADUniRule annotation1
Binding sitei337NADUniRule annotation1
Binding sitei406NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 218NADUniRule annotation3
Nucleotide bindingi279 – 284NADUniRule annotation6
Nucleotide bindingi358 – 360NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:MMAR_1295
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001292901 – 492AdenosylhomocysteinaseAdd BLAST492

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_1295.

Structurei

3D structure databases

ProteinModelPortaliB2HEP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiKYGCRES.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
PANTHERiPTHR23420. PTHR23420. 2 hits.
PfamiPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HEP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTETSLSA DTKNGIDFKI ADLSLADFGR KELRIAEHEM PGLMSLRREY
60 70 80 90 100
AEVQPLKGAR ISGSLHMTVQ TAVLIETLTA LGAEVRWASC NIFSTQDHAA
110 120 130 140 150
AAVVVGPHGT PEEPKGVPVF AWKGESLEEY WWCAEQMLTW PDSDKPANMI
160 170 180 190 200
LDDGGDATML VLRGMQYEKA GVVPPAEEDD SAEWKVFLGL LRSRFETDKG
210 220 230 240 250
KWTKIAESVK GVTEETTTGV LRLYQFAAAG DLAFPAINVN DSVTKSKFDN
260 270 280 290 300
KYGTRHSLID GINRGTDALI GGKKVLICGY GDVGKGCAEA MKGQGARVSV
310 320 330 340 350
TEIDPINALQ AMMEGFDVVT VEDAIGDADI VVTSTGNKDI IMLEHIKAMK
360 370 380 390 400
DHSILGNIGH FDNEIDMAGL ERSGATRTNI KPQVDLWTFG DTGRSIIVLS
410 420 430 440 450
EGRLLNLGNA TGHPSFVMSN SFANQTIAQI ELWTKNDEYD NEVYRLPKHL
460 470 480 490
DEKVARIHVE ALGGRLTKLT KDQAEYLGVD VEGPYKPDHY RY
Length:492
Mass (Da):53,885
Last modified:June 10, 2008 - v1
Checksum:iE8BDE534FE0A4449
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39753.1.
RefSeqiWP_012393163.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC39753; ACC39753; MMAR_1295.
KEGGimmi:MMAR_1295.
PATRICi18063379. VBIMycMar75906_1378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39753.1.
RefSeqiWP_012393163.1. NC_010612.1.

3D structure databases

ProteinModelPortaliB2HEP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_1295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC39753; ACC39753; MMAR_1295.
KEGGimmi:MMAR_1295.
PATRICi18063379. VBIMycMar75906_1378.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiKYGCRES.
OrthoDBiPOG091H00W2.

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
PANTHERiPTHR23420. PTHR23420. 2 hits.
PfamiPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAHH_MYCMM
AccessioniPrimary (citable) accession number: B2HEP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.