B2HED8 (G6PI_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	MMAR_4557

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000125741
Sites
	Active site	389	1	By similarity
	Active site	515	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2HED8 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 1CB16DC4408BDCA6	FASTA	554	60,311
	10 20 30 40 50 60 MTSEQSIPDI TATPAWEALR KHHDQIGETH LRQIFADDPN RGHDLTVTVG DLYIDYSKHR 70 80 90 100 110 120 ITRDTISLLV DLARTANLEA HRDQMFAGAH INTSEDRAVL HTALRLPRDA ELIVDGRNVV 130 140 150 160 170 180 EDVHAVLDAM GDFTDRLRSG EWTGATGKRI STVVNIGIGG SDLGPVMVYQ ALRHYADAGI 190 200 210 220 230 240 SARFVSNVDP ADLIATLADL DPATTLFIVA SKTFSTLETL TNATAARRWL TDALGDAAVS 250 260 270 280 290 300 QHFVAVSTNR RLVDDFGINT DNMFGFWDWV GGRYSVDSAI GLSVMAAIGR EAFADFLSGF 310 320 330 340 350 360 HIVDEHFRTA PLESNAPALL GLIGLWYSNF LGAQSRAVLP YSNDLARFAA YLQQLTMESN 370 380 390 400 410 420 GKSTRADGTA VTTDTGEIYW GEPGTNGQHA FYQLLHQGTR LVPADFIGFS QPIDDLPTVE 430 440 450 460 470 480 GTGSMHDLLM SNFFAQTQVL AFGKTAEEIA AEGTPAAVVP HKVMPGNRPS TSILANRLTP 490 500 510 520 530 540 SVLGQLIALY EHQVFTEGVV WGIDSFDQWG VELGKTQAKA LLPVITSDGS PQRQSDSSTD 550 ALVRRYRTQR GRTG

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-535 / M.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC42963.1.
RefSeq	YP_001852818.1. NC_010612.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2HED8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000031862; EBMYCP00000030302; EBMYCG00000031857.
GeneID	6228842.
GenomeReviews	Gene locus MMAR_4557 in contig CP000854_GR.
KEGG	mmi:MMAR_4557.
PATRIC	18070467. VBIMycMar75906_4896.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016991.
HOGENOM	HBG352954.
OMA	NSLPAWT.
ProtClustDB	PRK00179.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_MYCMM

Accession

Primary (citable) accession number: B2HED8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program