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B2HEC3

- PUR9_MYCMM

UniProt

B2HEC3 - PUR9_MYCMM

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-4578-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:MMAR_4542
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Bifunctional purine biosynthesis protein PurHPRO_1000096074Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_4542.

    Structurei

    3D structure databases

    ProteinModelPortaliB2HEC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiHRRAHAC.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2HEC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTDHIRRPI RRALISVYDK TGLVDLAQGL TAAGVEIVST GSTAKTIASK    50
    GIPVTRVEEL TGFPEVLDGR VKTLHPRVHA GLLADLRNPE HEAALAELGV 100
    EAFELVVVNL YPFSQTVESG ASVDECVEQI DIGGPSMVRA AAKNHPSVAV 150
    VTDPQGYDGV LAAVSSGGFT LAERKKLASL AFQHTAEYDI AVASWMQSTV 200
    APEQPETDFP RWFGRNWRRQ AMLRYGENPH QQAALYADPG AWPGLAQAEQ 250
    LHGKEMSYNN FTDADAAWRA AFDHEQKCVA IIKHANPCGI AISEVSVADA 300
    HRKAHACDPL SAYGGVIACN TEVSPEMAEY VSTIFTEVIV APAYAPAALD 350
    QLTKKKNIRV LVASEPQDGG AELRPISGGL LMQQRDQLDA AGDNPANWTL 400
    ATGSPADPAT LTDLVFAWRS CRAVKSNAIV IVADGATIGV GMGQVNRVDA 450
    ARLAVERGGE RVNGAVAASD AFFPFPDGLE TLTAAGVKAI VHPGGSVRDE 500
    EVTAAAAKAG ITLYLTGSRH FAH 523
    Length:523
    Mass (Da):55,438
    Last modified:June 10, 2008 - v1
    Checksum:iEA8AD53550D37C69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC42948.1.
    RefSeqiYP_001852803.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC42948; ACC42948; MMAR_4542.
    GeneIDi6228827.
    KEGGimmi:MMAR_4542.
    PATRICi18070435. VBIMycMar75906_4880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC42948.1 .
    RefSeqi YP_001852803.1. NC_010612.1.

    3D structure databases

    ProteinModelPortali B2HEC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_4542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC42948 ; ACC42948 ; MMAR_4542 .
    GeneIDi 6228827.
    KEGGi mmi:MMAR_4542.
    PATRICi 18070435. VBIMycMar75906_4880.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi HRRAHAC.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci MMAR216594:GJOB-4578-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / M.

    Entry informationi

    Entry nameiPUR9_MYCMM
    AccessioniPrimary (citable) accession number: B2HEC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3