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B2HEC3

- PUR9_MYCMM

UniProt

B2HEC3 - PUR9_MYCMM

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, MMAR_4542
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-4578-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:MMAR_4542
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096074Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_4542.

Structurei

3D structure databases

ProteinModelPortaliB2HEC3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B2HEC3-1 [UniParc]FASTAAdd to Basket

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MSTDHIRRPI RRALISVYDK TGLVDLAQGL TAAGVEIVST GSTAKTIASK    50
GIPVTRVEEL TGFPEVLDGR VKTLHPRVHA GLLADLRNPE HEAALAELGV 100
EAFELVVVNL YPFSQTVESG ASVDECVEQI DIGGPSMVRA AAKNHPSVAV 150
VTDPQGYDGV LAAVSSGGFT LAERKKLASL AFQHTAEYDI AVASWMQSTV 200
APEQPETDFP RWFGRNWRRQ AMLRYGENPH QQAALYADPG AWPGLAQAEQ 250
LHGKEMSYNN FTDADAAWRA AFDHEQKCVA IIKHANPCGI AISEVSVADA 300
HRKAHACDPL SAYGGVIACN TEVSPEMAEY VSTIFTEVIV APAYAPAALD 350
QLTKKKNIRV LVASEPQDGG AELRPISGGL LMQQRDQLDA AGDNPANWTL 400
ATGSPADPAT LTDLVFAWRS CRAVKSNAIV IVADGATIGV GMGQVNRVDA 450
ARLAVERGGE RVNGAVAASD AFFPFPDGLE TLTAAGVKAI VHPGGSVRDE 500
EVTAAAAKAG ITLYLTGSRH FAH 523
Length:523
Mass (Da):55,438
Last modified:June 10, 2008 - v1
Checksum:iEA8AD53550D37C69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC42948.1.
RefSeqiYP_001852803.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC42948; ACC42948; MMAR_4542.
GeneIDi6228827.
KEGGimmi:MMAR_4542.
PATRICi18070435. VBIMycMar75906_4880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC42948.1 .
RefSeqi YP_001852803.1. NC_010612.1.

3D structure databases

ProteinModelPortali B2HEC3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 216594.MMAR_4542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC42948 ; ACC42948 ; MMAR_4542 .
GeneIDi 6228827.
KEGGi mmi:MMAR_4542.
PATRICi 18070435. VBIMycMar75906_4880.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MMAR216594:GJOB-4578-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiPUR9_MYCMM
AccessioniPrimary (citable) accession number: B2HEC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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