Reviewed, UniProtKB/Swiss-Prot B2HDU8 (ADD_MYCMM)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	MMAR_1206

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Adenosine deaminase HAMAP MF_00540		PRO_1000128852
Sites
	Active site	208	1	Potential
	Active site	267	1	Potential
	Active site	300	1	Potential
	Active site	301	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	B2HDU8-1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 02039918E83D8BA0	FASTA	362	39,695
	10 20 30 40 50 60 MTDMPTLDAI RQAPKALLHD HLDGGLRPET VLDIAGQVGY DGLPSTDAGE LASWFRTQSH 70 80 90 100 110 120 SGSLERYLEP FSHTVAVMQT PEALYRVAYE CVEDLAADAV VYAEIRFAPE LHINQGLTFD 130 140 150 160 170 180 EIVDAVLAGF AAGERACAGA GCPIKVRLLV TAMRHAAMSR EIAELAIRFR DKGVVGFDIA 190 200 210 220 230 240 GAEAGYPPSR HLDAFEYMRD NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI 250 260 270 280 290 300 EVGPDGDVKL GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR SRFRVTVNTD 310 320 330 340 350 360 NRLMSDTSMS QEMYRLVETF GYGWSDIQRF TINAMKSAFI AFDERLEIID EVIKPRFAVL IG

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000854 Genomic DNA. Translation: ACC39664.1.
RefSeq	YP_001849519.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6225461.
GenomeReviews	Gene locus MMAR_1206 in contig CP000854_GR.
KEGG	mmi:MMAR_1206.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FLKKLDW.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_MYCMM

Accession

Primary (citable) accession number: B2HDU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	November 3, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)