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Protein

Adenosine deaminase

Gene

add

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Adenosine + H2O = inosine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191Zinc; catalyticUniRule annotation
Metal bindingi21 – 211Zinc; catalyticUniRule annotation
Binding sitei21 – 211SubstrateUniRule annotation
Binding sitei23 – 231SubstrateUniRule annotation
Binding sitei181 – 1811Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation
Metal bindingi208 – 2081Zinc; catalyticUniRule annotation
Active sitei211 – 2111Proton donorUniRule annotation
Sitei232 – 2321Important for catalytic activityUniRule annotation
Metal bindingi300 – 3001Zinc; catalyticUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-1212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)
Alternative name(s):
Adenosine aminohydrolaseUniRule annotation
Gene namesi
Name:addUniRule annotation
Ordered Locus Names:MMAR_1206
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Adenosine deaminasePRO_1000128852Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_1206.

Structurei

3D structure databases

ProteinModelPortaliB2HDU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

B2HDU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDMPTLDAI RQAPKALLHD HLDGGLRPET VLDIAGQVGY DGLPSTDAGE
60 70 80 90 100
LASWFRTQSH SGSLERYLEP FSHTVAVMQT PEALYRVAYE CVEDLAADAV
110 120 130 140 150
VYAEIRFAPE LHINQGLTFD EIVDAVLAGF AAGERACAGA GCPIKVRLLV
160 170 180 190 200
TAMRHAAMSR EIAELAIRFR DKGVVGFDIA GAEAGYPPSR HLDAFEYMRD
210 220 230 240 250
NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI EVGPDGDVKL
260 270 280 290 300
GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR SRFRVTVNTD
310 320 330 340 350
NRLMSDTSMS QEMYRLVETF GYGWSDIQRF TINAMKSAFI AFDERLEIID
360
EVIKPRFAVL IG
Length:362
Mass (Da):39,695
Last modified:June 10, 2008 - v1
Checksum:i02039918E83D8BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39664.1.
RefSeqiWP_012393086.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC39664; ACC39664; MMAR_1206.
KEGGimmi:MMAR_1206.
PATRICi18063201. VBIMycMar75906_1289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39664.1.
RefSeqiWP_012393086.1. NC_010612.1.

3D structure databases

ProteinModelPortaliB2HDU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_1206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC39664; ACC39664; MMAR_1206.
KEGGimmi:MMAR_1206.
PATRICi18063201. VBIMycMar75906_1289.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-1212-MONOMER.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADD_MYCMM
AccessioniPrimary (citable) accession number: B2HDU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.