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Protein

Alkyl hydroperoxide reductase AhpD

Gene

ahpD

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Proton donorUniRule annotation
Active sitei133 – 1331Cysteine sulfenic acid (-SOH) intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-2772-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpDUniRule annotation (EC:1.11.1.15UniRule annotation)
Alternative name(s):
Alkylhydroperoxidase AhpDUniRule annotation
Gene namesi
Name:ahpDUniRule annotation
Ordered Locus Names:MMAR_2754
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Alkyl hydroperoxide reductase AhpDPRO_0000359498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi130 ↔ 133By similarity
Disulfide bondi133 – 133Interchain (with AhpC); in linked formUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi216594.MMAR_2754.

Structurei

3D structure databases

ProteinModelPortaliB2HD59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AhpD family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108X7C. Bacteria.
COG2128. LUCA.
HOGENOMiHOG000261487.
KOiK04756.
OMAiAIMAMNN.
OrthoDBiEOG6PCQ0G.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00777. ahpD. 1 hit.
TIGR00778. ahpD_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

B2HD59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIENLKAAL PEYAKDLKLN LGSISRTTVL DEEQLWGTLL ASAAATRNAQ
60 70 80 90 100
VLAEIGAEAA DNLSAQAYQA ALGAVSIMGM NNVFYRGRGF LEGQYDDLRA
110 120 130 140 150
GLRMNIIANP GVDKANFELW SFAVSSVNGC SHCVVAHEHT LREAGVGREA
160 170
VLEALKAAAI VCGVAQALTA AQTLAAVG
Length:178
Mass (Da):18,647
Last modified:June 10, 2008 - v1
Checksum:iACE37D5D98410516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC41196.1.
RefSeqiWP_012394462.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC41196; ACC41196; MMAR_2754.
KEGGimmi:MMAR_2754.
PATRICi18066533. VBIMycMar75906_2946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC41196.1.
RefSeqiWP_012394462.1. NC_010612.1.

3D structure databases

ProteinModelPortaliB2HD59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_2754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC41196; ACC41196; MMAR_2754.
KEGGimmi:MMAR_2754.
PATRICi18066533. VBIMycMar75906_2946.

Phylogenomic databases

eggNOGiENOG4108X7C. Bacteria.
COG2128. LUCA.
HOGENOMiHOG000261487.
KOiK04756.
OMAiAIMAMNN.
OrthoDBiEOG6PCQ0G.

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-2772-MONOMER.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00777. ahpD. 1 hit.
TIGR00778. ahpD_dom. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiAHPD_MYCMM
AccessioniPrimary (citable) accession number: B2HD59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 10, 2008
Last modified: November 11, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.