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Protein

Actin-related protein 2/3 complex subunit 3

Gene

Arpc3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-3928662 EPHB-mediated forward signaling
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3UniRule annotation
Alternative name(s):
Arp2/3 complex 21 kDa subunitUniRule annotation
Gene namesi
Name:Arpc3Imported
Synonyms:Arpc3_predictedImported
ORF Names:rCG_21863Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311985 Arpc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000008673

Interactioni

Subunit structurei

Component of the Arp2/3 complex.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011499

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
HOGENOMiHOG000161465
HOVERGENiHBG050581
KOiK05756
OMAiKWWLSFT
OrthoDBiEOG091G0OUM
TreeFamiTF314598

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit

Sequencei

Sequence statusi: Complete.

B2GV73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSRSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ASKQEDETMR AYLQQLRQET GLRLCDKVFD
160 170
PQNDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,536
Last modified:June 10, 2008 - v1
Checksum:iB9CFF43107C667B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104314 Genomic DNA No translation available.
BC166554 mRNA Translation: AAI66554.1
CH473973 Genomic DNA Translation: EDM13687.1
RefSeqiNP_001099403.1, NM_001105933.1
UniGeneiRn.4233

Genome annotation databases

EnsembliENSRNOT00000011499; ENSRNOP00000011499; ENSRNOG00000008673
GeneIDi288669
KEGGirno:288669
UCSCiRGD:1311985 rat

Similar proteinsi

Entry informationi

Entry nameiB2GV73_RAT
AccessioniPrimary (citable) accession number: B2GV73
Secondary accession number(s): F1LRL8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health