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Protein

Arginine-hydroxylase NDUFAF5, mitochondrial

Gene

Ndufaf5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-hydroxylase NDUFAF5, mitochondrial (EC:1.-.-.-By similarity)
Alternative name(s):
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5Imported
Putative methyltransferase NDUFAF5Curated (EC:2.1.1.-Curated)
Gene namesi
Name:Ndufaf5Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1309829. Ndufaf5.

Subcellular locationi

  • Mitochondrion inner membrane By similarity

  • Note: Peripherally localized on the matrix face of the mitochondrial inner membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000035887930 – 343Arginine-hydroxylase NDUFAF5, mitochondrialAdd BLAST314

Proteomic databases

PaxDbiB2GV71.
PeptideAtlasiB2GV71.

PTM databases

iPTMnetiB2GV71.
PhosphoSitePlusiB2GV71.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004784.
GenevisibleiB2GV71. RN.

Interactioni

Subunit structurei

Interacts with NDUFAF8, leading to stabilize NDUFAF5. Interacts with NDUFS7.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006412.

Structurei

3D structure databases

ProteinModelPortaliB2GV71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2940. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00390000014687.
HOGENOMiHOG000265011.
HOVERGENiHBG107772.
InParanoidiB2GV71.
KOiK18162.
OMAiCRRPWAA.
OrthoDBiEOG091G0EZO.
PhylomeDBiB2GV71.
TreeFamiTF315222.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GV71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRVVLSRL YARLGGPAVS AGRGGRRGVA SSVPPSGSTS PRALNIFDRE
60 70 80 90 100
LKRKQKNWAA RQPEPMKFDY LKEEIGSRIA DRVYDIARDF PLALDIGCGR
110 120 130 140 150
GYIAQHLNKE TVGKIFQTDI AEHALKNSIE TDIPTVNILA DEEFLPFPEN
160 170 180 190 200
TFDLVVSSLS LHWVNDLPRA LEQIHYVLKP DGVFVGAMFG GDTLYELRCS
210 220 230 240 250
LQLAETEREG GFSPHISPFT AVNDLGHLLG RAGFNTLTVD TDEIQVNYPG
260 270 280 290 300
MFELMEDLKG MGESNCSWNR KALLHRDTML AAAAVYREMY SNEDGSIPAT
310 320 330 340
YQIYHMIGWK YHDSQARPAE RGSATVSFGD LARLNDTMSQ GKK
Length:343
Mass (Da):38,229
Last modified:June 10, 2008 - v1
Checksum:i5FFEE0F26E92A44D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166551 mRNA. Translation: AAI66551.1.
RefSeqiNP_001119843.1. NM_001126371.1.
UniGeneiRn.98718.

Genome annotation databases

EnsembliENSRNOT00000006412; ENSRNOP00000006412; ENSRNOG00000004784.
GeneIDi296190.
KEGGirno:296190.
UCSCiRGD:1309829. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166551 mRNA. Translation: AAI66551.1.
RefSeqiNP_001119843.1. NM_001126371.1.
UniGeneiRn.98718.

3D structure databases

ProteinModelPortaliB2GV71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006412.

PTM databases

iPTMnetiB2GV71.
PhosphoSitePlusiB2GV71.

Proteomic databases

PaxDbiB2GV71.
PeptideAtlasiB2GV71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006412; ENSRNOP00000006412; ENSRNOG00000004784.
GeneIDi296190.
KEGGirno:296190.
UCSCiRGD:1309829. rat.

Organism-specific databases

CTDi79133.
RGDi1309829. Ndufaf5.

Phylogenomic databases

eggNOGiKOG2940. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00390000014687.
HOGENOMiHOG000265011.
HOVERGENiHBG107772.
InParanoidiB2GV71.
KOiK18162.
OMAiCRRPWAA.
OrthoDBiEOG091G0EZO.
PhylomeDBiB2GV71.
TreeFamiTF315222.

Enzyme and pathway databases

ReactomeiR-RNO-6799198. Complex I biogenesis.

Miscellaneous databases

PROiB2GV71.

Gene expression databases

BgeeiENSRNOG00000004784.
GenevisibleiB2GV71. RN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUF5_RAT
AccessioniPrimary (citable) accession number: B2GV71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.