Ubl4a

Functionⁱ

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.By similarity

GO - Molecular functionⁱ

chaperone binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tail-anchored membrane protein insertion into ER membrane Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-like protein 4A
Gene namesⁱ	Name:Ubl4a Synonyms:Ubl4
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome X

Organism-specific databases

Rat genome database More...RGDⁱ	1563983 Ubl4a

RGDⁱ

1563983 Ubl4a

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000403739	1 – 157	Ubiquitin-like protein 4AAdd BLAST		157

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	48	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	90	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT complex and SGTA and therefore may regulate client proteins fate.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	B2GV38
PeptideAtlas More...PeptideAtlasⁱ	B2GV38
PRIDEⁱ	B2GV38

PTM databases

iPTMnetⁱ	B2GV38
PhosphoSitePlusⁱ	B2GV38

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000053061
Genevisibleⁱ	B2GV38 RN

Interactionⁱ

Subunit structureⁱ

Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with BAG6; the interaction is direct and required for UBL4A protein stability. Interacts with USP13; may be indirect via BAG6.By similarity

GO - Molecular functionⁱ

chaperone binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053153

STRINGⁱ

10116.ENSRNOP00000053153

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B2GV38
SMRⁱ	B2GV38
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 76	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST		76

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	96 – 138	Required and sufficient for interaction with BAG6By similarityAdd BLAST		43

Phylogenomic databases

eggNOGⁱ	KOG0001 Eukaryota COG5272 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111022
HOGENOMⁱ	HOG000006827
HOVERGENⁱ	HBG072205
InParanoidⁱ	B2GV38
OMAⁱ	YPGIKDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XVA
PhylomeDBⁱ	B2GV38
TreeFamⁱ	TF354228

Family and domain databases

InterProⁱ	View protein in InterPro IPR019956 Ubiquitin IPR029071 Ubiquitin-like_domsf IPR019954 Ubiquitin_CS IPR000626 Ubiquitin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00240 ubiquitin, 1 hit
PRINTSⁱ	PR00348 UBIQUITIN
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00299 UBIQUITIN_1, 1 hit PS50053 UBIQUITIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B2GV38-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQLTVKALQG RECSLQVAED ELVSTLKHLV SDKLNVPVRQ QRLLFKGKAL 
        60         70         80         90        100
ADEKRLSDYN IGPNSKLNLV VKPLEKVLLE EGSAHRLVDS SATPIWQLIS 
       110        120        130        140        150
KVLARHFSIG DASRVLEQLQ RDYDRSLSRL TLDDIERLAS RFLHPEVTEA 

MEKGFCK

Length:157

Mass (Da):17,791

Last modified:June 10, 2008 - v1

Checksum:ⁱE8F80221F03606A9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474099 Genomic DNA Translation: EDL84970.1 BC166513 mRNA Translation: AAI66513.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001099816.1, NM_001106346.2
UniGeneⁱ	Rn.1138

Genome annotation databases

Ensemblⁱ	ENSRNOT00000091810; ENSRNOP00000074769; ENSRNOG00000053061
GeneIDⁱ	293864
KEGGⁱ	rno:293864

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
B2GV38	Ubiquitin-like protein 4A		MOUSE		157
Housekeeping protein DXS254E (Fragment)		MUSSI		152
Ubiquitin-like protein 4A		CASCN		157
UPI0003334520		JACJA		157
UPI0004ED6FB9		NANGA		157
+5

Protein	Similar proteins		Species	Score	Length
B2GV38	Ubiquitin-like protein 4A		MOUSE		157
Housekeeping protein DXS254E (Fragment)		MUSSI		152
UPI0003334520		JACJA		157
Ubiquitin-like protein 4A		CASCN		157
UPI00076229D6		MARMA		157
+67

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474099 Genomic DNA Translation: EDL84970.1 BC166513 mRNA Translation: AAI66513.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001099816.1, NM_001106346.2
UniGeneⁱ	Rn.1138

3D structure databases

ProteinModelPortalⁱ	B2GV38
SMRⁱ	B2GV38
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053153

STRINGⁱ

10116.ENSRNOP00000053153

PTM databases

iPTMnetⁱ	B2GV38
PhosphoSitePlusⁱ	B2GV38

Proteomic databases

PaxDbⁱ	B2GV38
PeptideAtlas More...PeptideAtlasⁱ	B2GV38
PRIDEⁱ	B2GV38

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000091810; ENSRNOP00000074769; ENSRNOG00000053061
GeneIDⁱ	293864
KEGGⁱ	rno:293864

Organism-specific databases

CTDⁱ	8266
Rat genome database More...RGDⁱ	1563983 Ubl4a

Phylogenomic databases

eggNOGⁱ	KOG0001 Eukaryota COG5272 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111022
HOGENOMⁱ	HOG000006827
HOVERGENⁱ	HBG072205
InParanoidⁱ	B2GV38
OMAⁱ	YPGIKDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XVA
PhylomeDBⁱ	B2GV38
TreeFamⁱ	TF354228

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B2GV38

PROⁱ

PR:B2GV38

Gene expression databases

Bgeeⁱ	ENSRNOG00000053061
Genevisibleⁱ	B2GV38 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR019956 Ubiquitin IPR029071 Ubiquitin-like_domsf IPR019954 Ubiquitin_CS IPR000626 Ubiquitin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00240 ubiquitin, 1 hit
PRINTSⁱ	PR00348 UBIQUITIN
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00299 UBIQUITIN_1, 1 hit PS50053 UBIQUITIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBL4A_RAT
Accessionⁱ	B2GV38Primary (citable) accession number: B2GV38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
	Last sequence update:	June 10, 2008
	Last modified:	June 20, 2018
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2GV38 (UBL4A_RAT)

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Ubiquitin-like protein 4A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ