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Protein

Ubiquitin-like protein 4A

Gene

Ubl4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 4A
Gene namesi
Name:Ubl4a
Synonyms:Ubl4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1563983. Ubl4a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Ubiquitin-like protein 4APRO_0000403739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2GV38.
PeptideAtlasiB2GV38.
PRIDEiB2GV38.

PTM databases

iPTMnetiB2GV38.

Expressioni

Gene expression databases

GenevisibleiB2GV38. RN.

Interactioni

Subunit structurei

Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053153.

Structurei

3D structure databases

ProteinModelPortaliB2GV38.
SMRiB2GV38. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7676Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000006827.
HOVERGENiHBG072205.
InParanoidiB2GV38.
OMAiQRDYDRS.
OrthoDBiEOG7J70HV.
PhylomeDBiB2GV38.
TreeFamiTF354228.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GV38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTVKALQG RECSLQVAED ELVSTLKHLV SDKLNVPVRQ QRLLFKGKAL
60 70 80 90 100
ADEKRLSDYN IGPNSKLNLV VKPLEKVLLE EGSAHRLVDS SATPIWQLIS
110 120 130 140 150
KVLARHFSIG DASRVLEQLQ RDYDRSLSRL TLDDIERLAS RFLHPEVTEA

MEKGFCK
Length:157
Mass (Da):17,791
Last modified:June 10, 2008 - v1
Checksum:iE8F80221F03606A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474099 Genomic DNA. Translation: EDL84970.1.
BC166513 mRNA. Translation: AAI66513.1.
RefSeqiNP_001099816.1. NM_001106346.2.
UniGeneiRn.1138.

Genome annotation databases

EnsembliENSRNOT00000091810; ENSRNOP00000074769; ENSRNOG00000053061.
GeneIDi293864.
KEGGirno:293864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474099 Genomic DNA. Translation: EDL84970.1.
BC166513 mRNA. Translation: AAI66513.1.
RefSeqiNP_001099816.1. NM_001106346.2.
UniGeneiRn.1138.

3D structure databases

ProteinModelPortaliB2GV38.
SMRiB2GV38. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053153.

PTM databases

iPTMnetiB2GV38.

Proteomic databases

PaxDbiB2GV38.
PeptideAtlasiB2GV38.
PRIDEiB2GV38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091810; ENSRNOP00000074769; ENSRNOG00000053061.
GeneIDi293864.
KEGGirno:293864.

Organism-specific databases

CTDi8266.
RGDi1563983. Ubl4a.

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000006827.
HOVERGENiHBG072205.
InParanoidiB2GV38.
OMAiQRDYDRS.
OrthoDBiEOG7J70HV.
PhylomeDBiB2GV38.
TreeFamiTF354228.

Miscellaneous databases

PROiB2GV38.

Gene expression databases

GenevisibleiB2GV38. RN.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiUBL4A_RAT
AccessioniPrimary (citable) accession number: B2GV38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: June 10, 2008
Last modified: July 6, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.