Ubl4a

Functionⁱ

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.By similarity

GO - Molecular functionⁱ

chaperone binding
Source: RGD
Inferred from sequence orthologyⁱ
- 25535373

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tail-anchored membrane protein insertion into ER membrane Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-like protein 4A
Gene namesⁱ	Name:Ubl4a Synonyms:Ubl4
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome X

Organism-specific databases

Rat genome database More...RGDⁱ	1563983. Ubl4a.

RGDⁱ

1563983. Ubl4a.

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000403739	1 – 157	Ubiquitin-like protein 4AAdd BLAST		157

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	48	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	90	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT complex and SGTA and therefore may regulate client proteins fate.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	B2GV38.
PeptideAtlas More...PeptideAtlasⁱ	B2GV38.
PRIDEⁱ	B2GV38.

PTM databases

iPTMnetⁱ	B2GV38.
PhosphoSitePlusⁱ	B2GV38.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000053061.
Genevisibleⁱ	B2GV38. RN.

Interactionⁱ

Subunit structureⁱ

Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with USP13; may be indirect via BAG6.By similarity

GO - Molecular functionⁱ

chaperone binding
Source: RGD
Inferred from sequence orthologyⁱ
- 25535373

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053153.

STRINGⁱ

10116.ENSRNOP00000053153.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B2GV38.
SMRⁱ	B2GV38.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 76	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST		76

Phylogenomic databases

eggNOGⁱ	KOG0001. Eukaryota. COG5272. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111022.
HOGENOMⁱ	HOG000006827.
HOVERGENⁱ	HBG072205.
InParanoidⁱ	B2GV38.
OMAⁱ	YPGIKDG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XVA.
PhylomeDBⁱ	B2GV38.
TreeFamⁱ	TF354228.

Family and domain databases

InterProⁱ	View protein in InterPro IPR019956. Ubiquitin. IPR029071. Ubiquitin-like_domsf. IPR019954. Ubiquitin_CS. IPR000626. Ubiquitin_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00240. ubiquitin. 1 hit.
PRINTSⁱ	PR00348. UBIQUITIN.
SMARTⁱ	View protein in SMART SM00213. UBQ. 1 hit.
SUPFAMⁱ	SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00299. UBIQUITIN_1. 1 hit. PS50053. UBIQUITIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B2GV38-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQLTVKALQG RECSLQVAED ELVSTLKHLV SDKLNVPVRQ QRLLFKGKAL 
        60         70         80         90        100
ADEKRLSDYN IGPNSKLNLV VKPLEKVLLE EGSAHRLVDS SATPIWQLIS 
       110        120        130        140        150
KVLARHFSIG DASRVLEQLQ RDYDRSLSRL TLDDIERLAS RFLHPEVTEA 

MEKGFCK

Length:157

Mass (Da):17,791

Last modified:June 10, 2008 - v1

Checksum:ⁱE8F80221F03606A9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474099 Genomic DNA. Translation: EDL84970.1. BC166513 mRNA. Translation: AAI66513.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001099816.1. NM_001106346.2.
UniGeneⁱ	Rn.1138.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000091810; ENSRNOP00000074769; ENSRNOG00000053061.
GeneIDⁱ	293864.
KEGGⁱ	rno:293864.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B2GV38	P21126 Q3UK94 Q684Q9 Q91V47 Q920U6 A0A250YAG7 UPI0003334520 UPI0004ED6FB9 UPI00076229D6 A0A1I9KDT5	Mus musculus (Mouse) Mus spicilegus (Steppe mouse) Castor canadensis (Beaver) Jaculus jaculus (Lesser Egyptian jerboa) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Marmota marmota marmota (Alpine marmot) Handleyomys alfaroi (Alfaro's rice rat)	157	UniRef90_P21126	Cluster: Ubiquitin-like protein 4A	11

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B2GV38	P21126 Q3UK94 Q684Q9 Q91V47 Q920U6 UPI0003334520 A0A250YAG7 UPI00076229D6 UPI0004ED6FB9 A0A1I9KDT5 +61	Mus musculus (Mouse) Mus spicilegus (Steppe mouse) Jaculus jaculus (Lesser Egyptian jerboa) Castor canadensis (Beaver) Marmota marmota marmota (Alpine marmot) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Handleyomys alfaroi (Alfaro's rice rat) Monodelphis domestica (Gray short-tailed opossum) Phascolarctos cinereus (Koala) Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea) And more	157	UniRef50_P21126	Cluster: Ubiquitin-like protein 4A	72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474099 Genomic DNA. Translation: EDL84970.1. BC166513 mRNA. Translation: AAI66513.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001099816.1. NM_001106346.2.
UniGeneⁱ	Rn.1138.

3D structure databases

ProteinModelPortalⁱ	B2GV38.
SMRⁱ	B2GV38.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053153.

STRINGⁱ

10116.ENSRNOP00000053153.

PTM databases

iPTMnetⁱ	B2GV38.
PhosphoSitePlusⁱ	B2GV38.

Proteomic databases

PaxDbⁱ	B2GV38.
PeptideAtlas More...PeptideAtlasⁱ	B2GV38.
PRIDEⁱ	B2GV38.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000091810; ENSRNOP00000074769; ENSRNOG00000053061.
GeneIDⁱ	293864.
KEGGⁱ	rno:293864.

Organism-specific databases

CTDⁱ	8266.
Rat genome database More...RGDⁱ	1563983. Ubl4a.

Phylogenomic databases

eggNOGⁱ	KOG0001. Eukaryota. COG5272. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111022.
HOGENOMⁱ	HOG000006827.
HOVERGENⁱ	HBG072205.
InParanoidⁱ	B2GV38.
OMAⁱ	YPGIKDG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XVA.
PhylomeDBⁱ	B2GV38.
TreeFamⁱ	TF354228.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B2GV38.

PROⁱ

PR:B2GV38.

Gene expression databases

Bgeeⁱ	ENSRNOG00000053061.
Genevisibleⁱ	B2GV38. RN.

Family and domain databases

InterProⁱ	View protein in InterPro IPR019956. Ubiquitin. IPR029071. Ubiquitin-like_domsf. IPR019954. Ubiquitin_CS. IPR000626. Ubiquitin_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00240. ubiquitin. 1 hit.
PRINTSⁱ	PR00348. UBIQUITIN.
SMARTⁱ	View protein in SMART SM00213. UBQ. 1 hit.
SUPFAMⁱ	SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00299. UBIQUITIN_1. 1 hit. PS50053. UBIQUITIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBL4A_RAT
Accessionⁱ	B2GV38Primary (citable) accession number: B2GV38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
	Last sequence update:	June 10, 2008
	Last modified:	February 28, 2018
	This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2GV38 (UBL4A_RAT)

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Ubiquitin-like protein 4A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ