Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylserine synthase 2

Gene

Ptdss2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity).By similarity

Catalytic activityi

L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.

Pathwayi: phosphatidylserine biosynthesis

This protein is involved in the pathway phosphatidylserine biosynthesis, which is part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phosphatidylserine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1483101. Synthesis of PS.
UniPathwayiUPA00948.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine synthase 2 (EC:2.7.8.29)
Short name:
PSS-2
Short name:
PtdSer synthase 2
Alternative name(s):
Serine-exchange enzyme II
Gene namesi
Name:Ptdss2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307914. Ptdss2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 74LumenalSequence analysisAdd BLAST13
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 104CytoplasmicSequence analysis9
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 291LumenalSequence analysisAdd BLAST166
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313CytoplasmicSequence analysis1
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 354LumenalSequence analysisAdd BLAST20
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 381CytoplasmicSequence analysis6
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 471LumenalSequence analysisAdd BLAST69

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004160341 – 471Phosphatidylserine synthase 2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei14PhosphoserineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiB2GV22.
PeptideAtlasiB2GV22.
PRIDEiB2GV22.

PTM databases

iPTMnetiB2GV22.
PhosphoSitePlusiB2GV22.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015912.
GenevisibleiB2GV22. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021925.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2735. Eukaryota.
ENOG410XS7H. LUCA.
GeneTreeiENSGT00530000063576.
HOGENOMiHOG000005791.
HOVERGENiHBG053766.
InParanoidiB2GV22.
KOiK08730.
OMAiKPHKKLG.
OrthoDBiEOG091G0CSE.
PhylomeDBiB2GV22.
TreeFamiTF300012.

Family and domain databases

InterProiIPR004277. PSS.
[Graphical view]
PfamiPF03034. PSS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GV22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGERRVAG GSGSESPLLE GRRSTESEVY DDGTNTFFWR AHTLTVLFIL
60 70 80 90 100
TCALGYVTLL EETPQDTAYN TKRGIVASIL VFLCFGVTQA KDGPFSRPHP
110 120 130 140 150
AYWRFWLCVS VVYELFLIFI LFQTVHDGRQ FLKYVDPRLG VPLPERDYGG
160 170 180 190 200
NCLIYDADNK TDPFHNIWDK LDGFVPAHFI GWYLKTLMIR DWWMCMIISV
210 220 230 240 250
MFEFLEYSLE HQLPNFSECW WDHWIMDVLL CNGLGIYCGM KTLEWLSLKT
260 270 280 290 300
YKWQGLWNIP TYKGKMKRIA FQFTPYSWVR FEWKPASSLH RWLAVCGIIL
310 320 330 340 350
VFLLAELNTF YLKFVLWMPP EHYLVLLRLV FFVNVGGVAM REIYDFMDEL
360 370 380 390 400
KPHRKLGQQA WLVAAITVTE LLIVVKYDPH TLTLSLPFYI SQCWTLGSIL
410 420 430 440 450
VLTWTVWRFF LRDITMRYKE TRRQKQQSHQ AINNGDGHPG PEDDLPGTGT
460 470
AEEEGTTNDG VPAEEGPSAA S
Length:471
Mass (Da):54,722
Last modified:June 10, 2008 - v1
Checksum:i0C196AB61180DB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118351 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM11981.1.
BC166496 mRNA. Translation: AAI66496.1.
RefSeqiNP_001099786.1. NM_001106316.1.
UniGeneiRn.104893.

Genome annotation databases

EnsembliENSRNOT00000021925; ENSRNOP00000021925; ENSRNOG00000015912.
GeneIDi293620.
KEGGirno:293620.
UCSCiRGD:1307914. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118351 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM11981.1.
BC166496 mRNA. Translation: AAI66496.1.
RefSeqiNP_001099786.1. NM_001106316.1.
UniGeneiRn.104893.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021925.

PTM databases

iPTMnetiB2GV22.
PhosphoSitePlusiB2GV22.

Proteomic databases

PaxDbiB2GV22.
PeptideAtlasiB2GV22.
PRIDEiB2GV22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021925; ENSRNOP00000021925; ENSRNOG00000015912.
GeneIDi293620.
KEGGirno:293620.
UCSCiRGD:1307914. rat.

Organism-specific databases

CTDi81490.
RGDi1307914. Ptdss2.

Phylogenomic databases

eggNOGiKOG2735. Eukaryota.
ENOG410XS7H. LUCA.
GeneTreeiENSGT00530000063576.
HOGENOMiHOG000005791.
HOVERGENiHBG053766.
InParanoidiB2GV22.
KOiK08730.
OMAiKPHKKLG.
OrthoDBiEOG091G0CSE.
PhylomeDBiB2GV22.
TreeFamiTF300012.

Enzyme and pathway databases

UniPathwayiUPA00948.
ReactomeiR-RNO-1483101. Synthesis of PS.

Miscellaneous databases

PROiB2GV22.

Gene expression databases

BgeeiENSRNOG00000015912.
GenevisibleiB2GV22. RN.

Family and domain databases

InterProiIPR004277. PSS.
[Graphical view]
PfamiPF03034. PSS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTSS2_RAT
AccessioniPrimary (citable) accession number: B2GV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.