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Protein

Phosphatidylserine synthase 2

Gene

Ptdss2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity).By similarity

Catalytic activityi

L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.

Pathwayi: phosphatidylserine biosynthesis

This protein is involved in the pathway phosphatidylserine biosynthesis, which is part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phosphatidylserine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1483101. Synthesis of PS.
UniPathwayiUPA00948.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine synthase 2 (EC:2.7.8.29)
Short name:
PSS-2
Short name:
PtdSer synthase 2
Alternative name(s):
Serine-exchange enzyme II
Gene namesi
Name:Ptdss2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307914. Ptdss2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Topological domaini62 – 7413LumenalSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Topological domaini96 – 1049CytoplasmicSequence analysis
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Topological domaini126 – 291166LumenalSequence analysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence analysisAdd
BLAST
Topological domaini313 – 3131CytoplasmicSequence analysis
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Topological domaini335 – 35420LumenalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 3816CytoplasmicSequence analysis
Transmembranei382 – 40221HelicalSequence analysisAdd
BLAST
Topological domaini403 – 47169LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Phosphatidylserine synthase 2PRO_0000416034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei16 – 161PhosphoserineCombined sources
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiB2GV22.
PRIDEiB2GV22.

Expressioni

Gene expression databases

GenevisibleiB2GV22. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021925.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2735. Eukaryota.
ENOG410XS7H. LUCA.
GeneTreeiENSGT00530000063576.
HOGENOMiHOG000005791.
HOVERGENiHBG053766.
InParanoidiB2GV22.
KOiK08730.
OMAiKPHKKLG.
OrthoDBiEOG7CNZGB.
PhylomeDBiB2GV22.
TreeFamiTF300012.

Family and domain databases

InterProiIPR004277. PSS.
[Graphical view]
PfamiPF03034. PSS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GV22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGERRVAG GSGSESPLLE GRRSTESEVY DDGTNTFFWR AHTLTVLFIL
60 70 80 90 100
TCALGYVTLL EETPQDTAYN TKRGIVASIL VFLCFGVTQA KDGPFSRPHP
110 120 130 140 150
AYWRFWLCVS VVYELFLIFI LFQTVHDGRQ FLKYVDPRLG VPLPERDYGG
160 170 180 190 200
NCLIYDADNK TDPFHNIWDK LDGFVPAHFI GWYLKTLMIR DWWMCMIISV
210 220 230 240 250
MFEFLEYSLE HQLPNFSECW WDHWIMDVLL CNGLGIYCGM KTLEWLSLKT
260 270 280 290 300
YKWQGLWNIP TYKGKMKRIA FQFTPYSWVR FEWKPASSLH RWLAVCGIIL
310 320 330 340 350
VFLLAELNTF YLKFVLWMPP EHYLVLLRLV FFVNVGGVAM REIYDFMDEL
360 370 380 390 400
KPHRKLGQQA WLVAAITVTE LLIVVKYDPH TLTLSLPFYI SQCWTLGSIL
410 420 430 440 450
VLTWTVWRFF LRDITMRYKE TRRQKQQSHQ AINNGDGHPG PEDDLPGTGT
460 470
AEEEGTTNDG VPAEEGPSAA S
Length:471
Mass (Da):54,722
Last modified:June 10, 2008 - v1
Checksum:i0C196AB61180DB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118351 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM11981.1.
BC166496 mRNA. Translation: AAI66496.1.
RefSeqiNP_001099786.1. NM_001106316.1.
UniGeneiRn.104893.

Genome annotation databases

EnsembliENSRNOT00000021925; ENSRNOP00000021925; ENSRNOG00000015912.
GeneIDi293620.
KEGGirno:293620.
UCSCiRGD:1307914. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118351 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM11981.1.
BC166496 mRNA. Translation: AAI66496.1.
RefSeqiNP_001099786.1. NM_001106316.1.
UniGeneiRn.104893.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021925.

Proteomic databases

PaxDbiB2GV22.
PRIDEiB2GV22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021925; ENSRNOP00000021925; ENSRNOG00000015912.
GeneIDi293620.
KEGGirno:293620.
UCSCiRGD:1307914. rat.

Organism-specific databases

CTDi81490.
RGDi1307914. Ptdss2.

Phylogenomic databases

eggNOGiKOG2735. Eukaryota.
ENOG410XS7H. LUCA.
GeneTreeiENSGT00530000063576.
HOGENOMiHOG000005791.
HOVERGENiHBG053766.
InParanoidiB2GV22.
KOiK08730.
OMAiKPHKKLG.
OrthoDBiEOG7CNZGB.
PhylomeDBiB2GV22.
TreeFamiTF300012.

Enzyme and pathway databases

UniPathwayiUPA00948.
ReactomeiR-RNO-1483101. Synthesis of PS.

Miscellaneous databases

NextBioi636541.
PROiB2GV22.

Gene expression databases

GenevisibleiB2GV22. RN.

Family and domain databases

InterProiIPR004277. PSS.
[Graphical view]
PfamiPF03034. PSS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTSS2_RAT
AccessioniPrimary (citable) accession number: B2GV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.