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Protein

Cytosolic carboxypeptidase-like protein 5

Gene

Agbl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521ZincBy similarity
Metal bindingi255 – 2551ZincBy similarity
Active sitei303 – 3031NucleophileBy similarity
Metal bindingi435 – 4351ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase-like protein 5 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 5
Gene namesi
Name:Agbl5
Synonyms:Ccp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1598311. Agbl5.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity
  • Cytoplasmcytoskeletonspindle By similarity
  • Midbody By similarity

  • Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed. Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Cytosolic carboxypeptidase-like protein 5PRO_0000403762Add
BLAST

Proteomic databases

PaxDbiB2GV17.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011635.

Structurei

3D structure databases

ProteinModelPortaliB2GV17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiKOG3641. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00550000074405.
HOGENOMiHOG000067735.
HOVERGENiHBG068187.
InParanoidiB2GV17.
OMAiPDTIPPK.
OrthoDBiEOG718KBS.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GV17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRCGGLLF SSRFDSGNLA HVEKVETVPS DGEGVGGAAT APTSGSASSP
60 70 80 90 100
DYEFNVWTRP DCAETEYENG NRSWFYFSVR GGTPGKLIKI NIMNMNKQSK
110 120 130 140 150
LYSQGMAPFV RTLPSRPRWE RIRERPTFEM TETQFVLSFV HRFVEGRGAT
160 170 180 190 200
TFFAFCYPFS YSDCQDLLSQ LDQRFPENYS AHSSPLDSIY YHRELLCYSL
210 220 230 240 250
DGLRVDLLTI TSCHGLRDDR EPRLEQLFPD VGTPRPFRFT GKRIFFLSSR
260 270 280 290 300
VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
310 320 330 340 350
HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSKNPSNQ
360 370 380 390 400
QPSSLHLPPE VPLSDLEKAN NLHNELHLGQ SPDGENHDRW TETEPTEEKT
410 420 430 440 450
DPVWIMPQPI PELEEPAPDA IPPKESGVAY YVDLHGHASK RGCFMYGNSF
460 470 480 490 500
SDESTQVENM LYPKLISLNS AHFDFQGCNF SEKNMYARDR RDGQSKEGSG
510 520 530 540 550
RVAIYKASGI IHSYTLECNY NTGRSVNSIP AACHDNGRAS PPPPPTFPSR
560 570 580 590 600
YTVELFEQVG RALAIAALDM AECNPWPRIV LSEHSSLTNL RAWMLKHVRN
610 620 630 640 650
SRGLTSTANV GLNKKRGSRT PPKSNNGLPV SCSENALSRA RSFSTGTSTG
660 670 680 690 700
GSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVSHR VLGPVREPRC
710 720 730 740 750
PDRRRRQQQQ QQQQQQQQQQ QQQPLNQRST TSSLAPSPTL ASASPTSSRN
760 770 780 790 800
MGSCLLPNSL SLSGSSCPFS SSGDKPEAVM VIGKSLLGAG ARIPCIRTRL
810 820 830
QTCQRRVSAR RGPGFPRLGP GWAGAHRRLA EG
Length:832
Mass (Da):92,554
Last modified:June 10, 2008 - v1
Checksum:iD9977530F97FA44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166490 mRNA. Translation: AAI66490.1.
RefSeqiNP_001119844.1. NM_001126372.1.
UniGeneiRn.210663.

Genome annotation databases

EnsembliENSRNOT00000011635; ENSRNOP00000011635; ENSRNOG00000008612.
GeneIDi362710.
KEGGirno:362710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166490 mRNA. Translation: AAI66490.1.
RefSeqiNP_001119844.1. NM_001126372.1.
UniGeneiRn.210663.

3D structure databases

ProteinModelPortaliB2GV17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011635.

Proteomic databases

PaxDbiB2GV17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011635; ENSRNOP00000011635; ENSRNOG00000008612.
GeneIDi362710.
KEGGirno:362710.

Organism-specific databases

CTDi60509.
RGDi1598311. Agbl5.

Phylogenomic databases

eggNOGiKOG3641. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00550000074405.
HOGENOMiHOG000067735.
HOVERGENiHBG068187.
InParanoidiB2GV17.
OMAiPDTIPPK.
OrthoDBiEOG718KBS.

Miscellaneous databases

PROiB2GV17.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCBPC5_RAT
AccessioniPrimary (citable) accession number: B2GV17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: June 10, 2008
Last modified: June 8, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.