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Protein

Cytosolic carboxypeptidase-like protein 5

Gene

Agbl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi252ZincBy similarity1
Metal bindingi255ZincBy similarity1
Active sitei303NucleophileBy similarity1
Metal bindingi435ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase-like protein 5 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 5
Gene namesi
Name:Agbl5
Synonyms:Ccp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1598311 Agbl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037621 – 832Cytosolic carboxypeptidase-like protein 5Add BLAST832

Proteomic databases

PaxDbiB2GV17
PRIDEiB2GV17

Expressioni

Gene expression databases

BgeeiENSRNOG00000008612

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011635

Structurei

3D structure databases

ProteinModelPortaliB2GV17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiKOG3641 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00550000074405
HOGENOMiHOG000067735
HOVERGENiHBG068187
InParanoidiB2GV17
OMAiDQRFPEN
OrthoDBiEOG091G03CV

Family and domain databases

CDDicd06236 M14_AGBL5_like, 1 hit
InterProiView protein in InterPro
IPR034286 M14_AGBL5-like
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit

Sequencei

Sequence statusi: Complete.

B2GV17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRCGGLLF SSRFDSGNLA HVEKVETVPS DGEGVGGAAT APTSGSASSP
60 70 80 90 100
DYEFNVWTRP DCAETEYENG NRSWFYFSVR GGTPGKLIKI NIMNMNKQSK
110 120 130 140 150
LYSQGMAPFV RTLPSRPRWE RIRERPTFEM TETQFVLSFV HRFVEGRGAT
160 170 180 190 200
TFFAFCYPFS YSDCQDLLSQ LDQRFPENYS AHSSPLDSIY YHRELLCYSL
210 220 230 240 250
DGLRVDLLTI TSCHGLRDDR EPRLEQLFPD VGTPRPFRFT GKRIFFLSSR
260 270 280 290 300
VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
310 320 330 340 350
HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSKNPSNQ
360 370 380 390 400
QPSSLHLPPE VPLSDLEKAN NLHNELHLGQ SPDGENHDRW TETEPTEEKT
410 420 430 440 450
DPVWIMPQPI PELEEPAPDA IPPKESGVAY YVDLHGHASK RGCFMYGNSF
460 470 480 490 500
SDESTQVENM LYPKLISLNS AHFDFQGCNF SEKNMYARDR RDGQSKEGSG
510 520 530 540 550
RVAIYKASGI IHSYTLECNY NTGRSVNSIP AACHDNGRAS PPPPPTFPSR
560 570 580 590 600
YTVELFEQVG RALAIAALDM AECNPWPRIV LSEHSSLTNL RAWMLKHVRN
610 620 630 640 650
SRGLTSTANV GLNKKRGSRT PPKSNNGLPV SCSENALSRA RSFSTGTSTG
660 670 680 690 700
GSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVSHR VLGPVREPRC
710 720 730 740 750
PDRRRRQQQQ QQQQQQQQQQ QQQPLNQRST TSSLAPSPTL ASASPTSSRN
760 770 780 790 800
MGSCLLPNSL SLSGSSCPFS SSGDKPEAVM VIGKSLLGAG ARIPCIRTRL
810 820 830
QTCQRRVSAR RGPGFPRLGP GWAGAHRRLA EG
Length:832
Mass (Da):92,554
Last modified:June 10, 2008 - v1
Checksum:iD9977530F97FA44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166490 mRNA Translation: AAI66490.1
RefSeqiNP_001119844.1, NM_001126372.1
UniGeneiRn.210663

Genome annotation databases

EnsembliENSRNOT00000011635; ENSRNOP00000011635; ENSRNOG00000008612
GeneIDi362710
KEGGirno:362710

Similar proteinsi

Entry informationi

Entry nameiCBPC5_RAT
AccessioniPrimary (citable) accession number: B2GV17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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