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Protein

Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Gene

Oxct1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).By similarity

Catalytic activityi

Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.PROSITE-ProRule annotationBy similarity

Pathwayi: succinyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (Oxct1), Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial (Oxct2a)
This subpathway is part of the pathway succinyl-CoA degradation, which is itself part of Ketone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA, the pathway succinyl-CoA degradation and in Ketone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3445-glutamyl coenzyme A thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • 3-oxoacid CoA-transferase activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • adipose tissue development Source: RGD
  • brain development Source: RGD
  • cellular ketone body metabolic process Source: RGD
  • heart development Source: RGD
  • ketone body catabolic process Source: Ensembl
  • ketone catabolic process Source: Ensembl
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  • response to activity Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to hormone Source: RGD
  • response to nutrient Source: RGD
  • response to starvation Source: RGD

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.8.3.5 5301
ReactomeiR-RNO-77108 Utilization of Ketone Bodies
UniPathwayiUPA00929; UER00894

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC:2.8.3.5)
Alternative name(s):
3-oxoacid CoA-transferase 1
Somatic-type succinyl-CoA:3-oxoacid CoA-transferase
Short name:
SCOT-s
Gene namesi
Name:Oxct1Imported
Synonyms:OxctBy similarity, ScotBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1584008 Oxct1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionBy similarityAdd BLAST39
ChainiPRO_000034912740 – 520Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineBy similarity1
Modified residuei185N6-succinyllysineBy similarity1
Modified residuei418N6-succinyllysineBy similarity1
Modified residuei421N6-succinyllysineBy similarity1
Modified residuei455N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2GV06
PeptideAtlasiB2GV06
PRIDEiB2GV06

PTM databases

iPTMnetiB2GV06
PhosphoSitePlusiB2GV06

Expressioni

Gene expression databases

BgeeiENSRNOG00000043094
GenevisibleiB2GV06 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063646

Structurei

3D structure databases

ProteinModelPortaliB2GV06
SMRiB2GV06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-oxoacid CoA-transferase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3822 Eukaryota
COG1788 LUCA
COG2057 LUCA
GeneTreeiENSGT00390000009130
HOGENOMiHOG000221244
HOVERGENiHBG002310
InParanoidiB2GV06
KOiK01027
OMAiNPAYSGE
OrthoDBiEOG091G0D3X
PhylomeDBiB2GV06

Family and domain databases

InterProiView protein in InterPro
IPR012792 3-oxoacid_CoA-transf_A
IPR012791 3-oxoacid_CoA-transf_B
IPR014388 3-oxoacid_CoA-transferase
IPR004165 CoA_trans_fam_I
IPR004164 CoA_transf_AS
IPR004163 CoA_transf_BS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR13707 PTHR13707, 1 hit
PfamiView protein in Pfam
PF01144 CoA_trans, 2 hits
PIRSFiPIRSF000858 SCOT-t, 1 hit
SMARTiView protein in SMART
SM00882 CoA_trans, 2 hits
SUPFAMiSSF100950 SSF100950, 2 hits
TIGRFAMsiTIGR02429 pcaI_scoA_fam, 1 hit
TIGR02428 pcaJ_scoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01273 COA_TRANSF_1, 1 hit
PS01274 COA_TRANSF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GV06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALKLLSSG LRLCASARNS RGALHKGCAC YFSVSTRHHT KFYTDPVEAV
60 70 80 90 100
KDIPNGATLL VGGFGLCGIP ENLIGALLKT GVKDLTAVSN NAGVDNFGLG
110 120 130 140 150
LLLRSKQIKR MISSYVGENA EFERQFLSGE LEVELTPQGT LAERIRAGGA
160 170 180 190 200
GVPAFYTSTG YGTLVQEGGS PIKYNKDGSV AIASKPREVR EFRGQHFILE
210 220 230 240 250
EAITGDFALV KAWKADRAGN VIFRKSARNF NLPMCKAAGT TVVEVEEIVD
260 270 280 290 300
IGSFAPEDIH IPKIYVHRLI KGEKYEKRIE RLSLRKEGEG KAKSGKPGED
310 320 330 340 350
VRERIIKRAA LEFEDGMYAN LGIGIPLLAS NFISPNMTVH LQSENGVLGL
360 370 380 390 400
GPYPLKDEAD ADLINAGKET VTVLPGASFF SSDESFAMIR GGHVNLTMLG
410 420 430 440 450
AMQVSKYGDL ANWMIPGKMV KGMGGAMDLV SSSKTKVVVT MEHSAKGNAH
460 470 480 490 500
KIMEKCTLPL TGKQCVNRII TEKGVFDVDK KNGLTLIELW EGLTVDDIRK
510 520
STGCDFAVSP NLMPMQQIST
Length:520
Mass (Da):56,204
Last modified:June 10, 2008 - v1
Checksum:iD34D4F805665BC63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474048 Genomic DNA Translation: EDL75738.1
BC166478 mRNA Translation: AAI66478.1
RefSeqiNP_001121052.1, NM_001127580.1
UniGeneiRn.98472

Genome annotation databases

EnsembliENSRNOT00000065313; ENSRNOP00000063646; ENSRNOG00000043094
GeneIDi690163
KEGGirno:690163

Similar proteinsi

Entry informationi

Entry nameiSCOT1_RAT
AccessioniPrimary (citable) accession number: B2GV06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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