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B2GUZ5

- CAZA1_RAT

UniProt

B2GUZ5 - CAZA1_RAT

Protein

F-actin-capping protein subunit alpha-1

Gene

Capza1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro
    2. barbed-end actin filament capping Source: Ensembl

    Keywords - Molecular functioni

    Actin capping

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-actin-capping protein subunit alpha-1By similarity
    Alternative name(s):
    CapZ alpha-1By similarity
    Gene namesi
    Name:Capza1By similarity
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1587438. Capza1.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cortical cytoskeleton Source: Ensembl
    2. F-actin capping protein complex Source: Ensembl
    3. membrane Source: Ensembl
    4. WASH complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 286285F-actin-capping protein subunit alpha-1By similarityPRO_0000349121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei19 – 191N6-acetyllysineBy similarity
    Modified residuei97 – 971N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiB2GUZ5.
    PRIDEiB2GUZ5.

    2D gel databases

    World-2DPAGE0004:B2GUZ5.

    Expressioni

    Gene expression databases

    GenevestigatoriB2GUZ5.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. Interacts with S100B By similarity. Interacts with S100A1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi605958. 3 interactions.
    STRINGi10116.ENSRNOP00000018713.

    Structurei

    3D structure databases

    ProteinModelPortaliB2GUZ5.
    SMRiB2GUZ5. Positions 7-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the F-actin-capping protein alpha subunit family.Sequence Analysis

    Phylogenomic databases

    eggNOGiNOG261759.
    GeneTreeiENSGT00390000006476.
    HOGENOMiHOG000036539.
    HOVERGENiHBG050810.
    KOiK10364.
    OMAiACDSALR.
    OrthoDBiEOG71ZP25.

    Family and domain databases

    InterProiIPR002189. CapZ_alpha.
    IPR017865. F-actin_cap_asu_CS.
    [Graphical view]
    PANTHERiPTHR10653. PTHR10653. 1 hit.
    PfamiPF01267. F-actin_cap_A. 1 hit.
    [Graphical view]
    PRINTSiPR00191. FACTINCAPA.
    PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
    PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B2GUZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA    50
    AHAFAQYNMD QFTPVKIEGY DDQVLITEHG DLGNSRFLDP RNKISFKFDH 100
    LRKEASDPQP EDVDGGLKSW RDSCDSALRA YVKDHYSNGF CTVYAKTIDG 150
    QQTIIACIES HQFQPKNFWN GRWRSEWKFT ITPPTAQVVG VLKIQVHYYE 200
    DGNVQLVSHK DVQDSVTVSN EVQTAKEFIK IIESAENEYQ TAISENYQTM 250
    SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA 286
    Length:286
    Mass (Da):32,910
    Last modified:June 10, 2008 - v1
    Checksum:i0CB060C67D9E84C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166464 mRNA. Translation: AAI66464.1.
    RefSeqiNP_001103095.2. NM_001109625.2.
    UniGeneiRn.13838.

    Genome annotation databases

    EnsembliENSRNOT00000056015; ENSRNOP00000052868; ENSRNOG00000013538.
    GeneIDi691149.
    KEGGirno:691149.
    UCSCiRGD:1587438. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166464 mRNA. Translation: AAI66464.1 .
    RefSeqi NP_001103095.2. NM_001109625.2.
    UniGenei Rn.13838.

    3D structure databases

    ProteinModelPortali B2GUZ5.
    SMRi B2GUZ5. Positions 7-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 605958. 3 interactions.
    STRINGi 10116.ENSRNOP00000018713.

    2D gel databases

    World-2DPAGE 0004:B2GUZ5.

    Proteomic databases

    PaxDbi B2GUZ5.
    PRIDEi B2GUZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000056015 ; ENSRNOP00000052868 ; ENSRNOG00000013538 .
    GeneIDi 691149.
    KEGGi rno:691149.
    UCSCi RGD:1587438. rat.

    Organism-specific databases

    CTDi 829.
    RGDi 1587438. Capza1.

    Phylogenomic databases

    eggNOGi NOG261759.
    GeneTreei ENSGT00390000006476.
    HOGENOMi HOG000036539.
    HOVERGENi HBG050810.
    KOi K10364.
    OMAi ACDSALR.
    OrthoDBi EOG71ZP25.

    Miscellaneous databases

    NextBioi 742458.

    Gene expression databases

    Genevestigatori B2GUZ5.

    Family and domain databases

    InterProi IPR002189. CapZ_alpha.
    IPR017865. F-actin_cap_asu_CS.
    [Graphical view ]
    PANTHERi PTHR10653. PTHR10653. 1 hit.
    Pfami PF01267. F-actin_cap_A. 1 hit.
    [Graphical view ]
    PRINTSi PR00191. FACTINCAPA.
    PROSITEi PS00748. F_ACTIN_CAPPING_A_1. 1 hit.
    PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown Norway.
      Tissue: Embryonic lungImported.
    2. "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K., Sundaram C.S., Bhargava P.
      Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    3. Cited for: STRUCTURE BY NMR OF 265-276 IN COMPLEX WITH S100A1, SUBUNIT.

    Entry informationi

    Entry nameiCAZA1_RAT
    AccessioniPrimary (citable) accession number: B2GUZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3