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B2GUZ5

- CAZA1_RAT

UniProt

B2GUZ5 - CAZA1_RAT

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Protein

F-actin-capping protein subunit alpha-1

Gene

Capza1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
  2. barbed-end actin filament capping Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha-1By similarity
Alternative name(s):
CapZ alpha-1By similarity
Gene namesi
Name:Capza1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1587438. Capza1.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. cortical cytoskeleton Source: Ensembl
  3. F-actin capping protein complex Source: Ensembl
  4. membrane Source: Ensembl
  5. WASH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 286285F-actin-capping protein subunit alpha-1By similarityPRO_0000349121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei19 – 191N6-acetyllysineBy similarity
Modified residuei97 – 971N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB2GUZ5.
PRIDEiB2GUZ5.

2D gel databases

World-2DPAGE0004:B2GUZ5.

Expressioni

Gene expression databases

GenevestigatoriB2GUZ5.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. Interacts with S100B (By similarity). Interacts with S100A1.By similarity1 Publication

Protein-protein interaction databases

BioGridi605958. 3 interactions.
STRINGi10116.ENSRNOP00000018713.

Structurei

3D structure databases

ProteinModelPortaliB2GUZ5.
SMRiB2GUZ5. Positions 7-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the F-actin-capping protein alpha subunit family.Sequence Analysis

Phylogenomic databases

eggNOGiNOG261759.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiB2GUZ5.
KOiK10364.
OMAiACDSALR.
OrthoDBiEOG71ZP25.

Family and domain databases

InterProiIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSiPR00191. FACTINCAPA.
PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GUZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA
60 70 80 90 100
AHAFAQYNMD QFTPVKIEGY DDQVLITEHG DLGNSRFLDP RNKISFKFDH
110 120 130 140 150
LRKEASDPQP EDVDGGLKSW RDSCDSALRA YVKDHYSNGF CTVYAKTIDG
160 170 180 190 200
QQTIIACIES HQFQPKNFWN GRWRSEWKFT ITPPTAQVVG VLKIQVHYYE
210 220 230 240 250
DGNVQLVSHK DVQDSVTVSN EVQTAKEFIK IIESAENEYQ TAISENYQTM
260 270 280
SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA
Length:286
Mass (Da):32,910
Last modified:June 10, 2008 - v1
Checksum:i0CB060C67D9E84C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166464 mRNA. Translation: AAI66464.1.
RefSeqiNP_001103095.2. NM_001109625.2.
UniGeneiRn.13838.

Genome annotation databases

EnsembliENSRNOT00000056015; ENSRNOP00000052868; ENSRNOG00000013538.
GeneIDi691149.
KEGGirno:691149.
UCSCiRGD:1587438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166464 mRNA. Translation: AAI66464.1 .
RefSeqi NP_001103095.2. NM_001109625.2.
UniGenei Rn.13838.

3D structure databases

ProteinModelPortali B2GUZ5.
SMRi B2GUZ5. Positions 7-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 605958. 3 interactions.
STRINGi 10116.ENSRNOP00000018713.

2D gel databases

World-2DPAGE 0004:B2GUZ5.

Proteomic databases

PaxDbi B2GUZ5.
PRIDEi B2GUZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000056015 ; ENSRNOP00000052868 ; ENSRNOG00000013538 .
GeneIDi 691149.
KEGGi rno:691149.
UCSCi RGD:1587438. rat.

Organism-specific databases

CTDi 829.
RGDi 1587438. Capza1.

Phylogenomic databases

eggNOGi NOG261759.
GeneTreei ENSGT00390000006476.
HOGENOMi HOG000036539.
HOVERGENi HBG050810.
InParanoidi B2GUZ5.
KOi K10364.
OMAi ACDSALR.
OrthoDBi EOG71ZP25.

Miscellaneous databases

NextBioi 742458.

Gene expression databases

Genevestigatori B2GUZ5.

Family and domain databases

InterProi IPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view ]
PANTHERi PTHR10653. PTHR10653. 1 hit.
Pfami PF01267. F-actin_cap_A. 1 hit.
[Graphical view ]
PRINTSi PR00191. FACTINCAPA.
PROSITEi PS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Embryonic lungImported.
  2. "Proteome profile of the mature rat olfactory bulb."
    Maurya D.K., Sundaram C.S., Bhargava P.
    Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  3. Cited for: STRUCTURE BY NMR OF 265-276 IN COMPLEX WITH S100A1, SUBUNIT.

Entry informationi

Entry nameiCAZA1_RAT
AccessioniPrimary (citable) accession number: B2GUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3