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Protein

F-actin-capping protein subunit alpha-1

Gene

Capza1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-RNO-879415. Advanced glycosylation endproduct receptor signaling.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha-1By similarity
Alternative name(s):
CapZ alpha-1By similarity
Gene namesi
Name:Capza1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1587438. Capza1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003491212 – 286F-actin-capping protein subunit alpha-1By similarityAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiB2GUZ5.
PeptideAtlasiB2GUZ5.
PRIDEiB2GUZ5.

2D gel databases

World-2DPAGE0004:B2GUZ5.

PTM databases

iPTMnetiB2GUZ5.
PhosphoSitePlusiB2GUZ5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013538.
GenevisibleiB2GUZ5. RN.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. Interacts with S100B (By similarity). Interacts with S100A1.By similarity1 Publication

Protein-protein interaction databases

BioGridi605958. 3 interactors.
STRINGi10116.ENSRNOP00000052868.

Structurei

3D structure databases

ProteinModelPortaliB2GUZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the F-actin-capping protein alpha subunit family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0836. Eukaryota.
ENOG410ZAWX. LUCA.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiB2GUZ5.
KOiK10364.
OMAiSHAFSQY.
OrthoDBiEOG091G0KST.

Family and domain databases

InterProiIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSiPR00191. FACTINCAPA.
PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GUZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA
60 70 80 90 100
AHAFAQYNMD QFTPVKIEGY DDQVLITEHG DLGNSRFLDP RNKISFKFDH
110 120 130 140 150
LRKEASDPQP EDVDGGLKSW RDSCDSALRA YVKDHYSNGF CTVYAKTIDG
160 170 180 190 200
QQTIIACIES HQFQPKNFWN GRWRSEWKFT ITPPTAQVVG VLKIQVHYYE
210 220 230 240 250
DGNVQLVSHK DVQDSVTVSN EVQTAKEFIK IIESAENEYQ TAISENYQTM
260 270 280
SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA
Length:286
Mass (Da):32,910
Last modified:June 10, 2008 - v1
Checksum:i0CB060C67D9E84C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166464 mRNA. Translation: AAI66464.1.
RefSeqiNP_001103095.2. NM_001109625.2.
UniGeneiRn.13838.

Genome annotation databases

EnsembliENSRNOT00000056015; ENSRNOP00000052868; ENSRNOG00000013538.
GeneIDi691149.
KEGGirno:691149.
UCSCiRGD:1587438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166464 mRNA. Translation: AAI66464.1.
RefSeqiNP_001103095.2. NM_001109625.2.
UniGeneiRn.13838.

3D structure databases

ProteinModelPortaliB2GUZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi605958. 3 interactors.
STRINGi10116.ENSRNOP00000052868.

PTM databases

iPTMnetiB2GUZ5.
PhosphoSitePlusiB2GUZ5.

2D gel databases

World-2DPAGE0004:B2GUZ5.

Proteomic databases

PaxDbiB2GUZ5.
PeptideAtlasiB2GUZ5.
PRIDEiB2GUZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056015; ENSRNOP00000052868; ENSRNOG00000013538.
GeneIDi691149.
KEGGirno:691149.
UCSCiRGD:1587438. rat.

Organism-specific databases

CTDi829.
RGDi1587438. Capza1.

Phylogenomic databases

eggNOGiKOG0836. Eukaryota.
ENOG410ZAWX. LUCA.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiB2GUZ5.
KOiK10364.
OMAiSHAFSQY.
OrthoDBiEOG091G0KST.

Enzyme and pathway databases

ReactomeiR-RNO-879415. Advanced glycosylation endproduct receptor signaling.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiB2GUZ5.

Gene expression databases

BgeeiENSRNOG00000013538.
GenevisibleiB2GUZ5. RN.

Family and domain databases

InterProiIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSiPR00191. FACTINCAPA.
PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAZA1_RAT
AccessioniPrimary (citable) accession number: B2GUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.