Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2GUZ5 (CAZA1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-actin-capping protein subunit alpha-1
Alternative name(s):
CapZ alpha-1
Gene names
Name:Capza1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments By similarity. UniProtKB P52907

Subunit structure

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. Interacts with S100B By similarity. Interacts with S100A1. Ref.3

Subcellular location

Cytoplasmcytoskeleton Ref.2.

Sequence similarities

Belongs to the F-actin-capping protein alpha subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity UniProtKB P52907
Chain2 – 286285F-actin-capping protein subunit alpha-1 UniProtKB P52907
PRO_0000349121

Amino acid modifications

Modified residue21N-acetylalanine By similarity UniProtKB P52907
Modified residue191N6-acetyllysine By similarity
Modified residue971N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2GUZ5 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 0CB060C67D9E84C0

FASTA28632,910
        10         20         30         40         50         60 
MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD 

        70         80         90        100        110        120 
QFTPVKIEGY DDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EDVDGGLKSW 

       130        140        150        160        170        180 
RDSCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT 

       190        200        210        220        230        240 
ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSVTVSN EVQTAKEFIK IIESAENEYQ 

       250        260        270        280 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Brown Norway.
Tissue: Embryonic lung.
[2]"Proteome profile of the mature rat olfactory bulb."
Maurya D.K., Sundaram C.S., Bhargava P.
Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[3]"Solution structure of S100A1 bound to the CapZ peptide (TRTK12)."
Wright N.T., Cannon B.R., Wilder P.T., Morgan M.T., Varney K.M., Zimmer D.B., Weber D.J.
J. Mol. Biol. 386:1265-1277(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 265-276 IN COMPLEX WITH S100A1, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC166464 mRNA. Translation: AAI66464.1.
RefSeqNP_001103095.2. NM_001109625.2.
UniGeneRn.13838.

3D structure databases

ProteinModelPortalB2GUZ5.
SMRB2GUZ5. Positions 7-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid605958. 3 interactions.
STRING10116.ENSRNOP00000018713.

2D gel databases

World-2DPAGE0004:B2GUZ5.

Proteomic databases

PaxDbB2GUZ5.
PRIDEB2GUZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000056015; ENSRNOP00000052868; ENSRNOG00000013538.
GeneID691149.
KEGGrno:691149.
UCSCRGD:1587438. rat.

Organism-specific databases

CTD829.
RGD1587438. Capza1.

Phylogenomic databases

eggNOGNOG261759.
GeneTreeENSGT00390000006476.
HOGENOMHOG000036539.
HOVERGENHBG050810.
KOK10364.
OMAACDSALR.
OrthoDBEOG71ZP25.

Gene expression databases

GenevestigatorB2GUZ5.

Family and domain databases

InterProIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERPTHR10653. PTHR10653. 1 hit.
PfamPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSPR00191. FACTINCAPA.
PROSITEPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio742458.

Entry information

Entry nameCAZA1_RAT
AccessionPrimary (citable) accession number: B2GUZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families