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Protein
Submitted name:

S-phase kinase-associated protein 2

Gene

Skp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-RNO-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-RNO-5689880. Ub-specific processing proteases.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-8951664. Neddylation.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
S-phase kinase-associated protein 2Imported
Submitted name:
S-phase kinase-associated protein 2 (P45)Imported
Submitted name:
Similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1) (Predicted), isoform CRA_bImported
Gene namesi
Name:Skp2Imported
Synonyms:RGD1562456_predictedImported
ORF Names:rCG_50990Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1562456. Skp2.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSRNOG00000059059.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023101.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 140F-boxInterPro annotationAdd BLAST47

Phylogenomic databases

eggNOGiKOG2120. Eukaryota.
ENOG410Z2W2. LUCA.
GeneTreeiENSGT00390000007918.
HOGENOMiHOG000247037.
HOVERGENiHBG047488.
KOiK03875.
OMAiEIWGIRC.
OrthoDBiEOG091G0EYN.
TreeFamiTF352582.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00367. LRR_CC. 4 hits.
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

B2GUZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRKHLQEIP DQSSNVTTSF TWGWDSSKTS ELLSGMGVSA LEKEEVDSEN
60 70 80 90 100
IPHGLLSNLG HPQSPPRKRL KSKGSDKDFV IIRRPKLNRE NFPGVSWDSL
110 120 130 140 150
PDELLLGIFS CLCLPELLRV SGVCKRWYRL SLDESLWQSL DLAGKNLHPD
160 170 180 190 200
VTVRLLSRGV VAFRCPRSFM EQPLGESFSS FRVQHMDLSN SVINVSNLHG
210 220 230 240 250
ILSECSKLQN LSLEGLQLSD PIVTTLAQNE NLVRLNLCGC SGFSESAVAT
260 270 280 290 300
LLSSCSRLDE LNLSWCFDFT EKHVQAAVAH LPDTLTQLNL SGYRKNLQKT
310 320 330 340 350
DLCTLIKRCP NLVRLDLSDS IMLKNDCFPE FFQLNYLQHL SLSRCYDIIP
360 370 380 390 400
ETLLELGEIP TLKTLQVFGI VPDGTLQLLR EALPRLQINC AYFTSIARPT
410 420
MDNKKNPEIW GIKCRLTLQK PSL
Length:423
Mass (Da):47,650
Last modified:June 10, 2008 - v1
Checksum:i3AC0149B200B8110
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008439 Genomic DNA. No translation available.
BC166459 mRNA. Translation: AAI66459.1.
CH474048 Genomic DNA. Translation: EDL75674.1.
RefSeqiNP_001099886.1. NM_001106416.2.
UniGeneiRn.154278.

Genome annotation databases

EnsembliENSRNOT00000089178; ENSRNOP00000074788; ENSRNOG00000059059.
GeneIDi294790.
KEGGirno:294790.

Similar proteinsi

Entry informationi

Entry nameiB2GUZ0_RAT
AccessioniPrimary (citable) accession number: B2GUZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported