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B2GUX4

- UBP21_RAT

UniProt

B2GUX4 - UBP21_RAT

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Protein
Ubiquitin carboxyl-terminal hydrolase 21
Gene
Usp21
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei221 – 2211Nucleophile By similarity
Metal bindingi384 – 3841Zinc By similarity
Metal bindingi387 – 3871Zinc By similarity
Metal bindingi437 – 4371Zinc By similarity
Metal bindingi440 – 4401Zinc By similarity
Active sitei518 – 5181Proton acceptor By similarity

GO - Molecular functioni

  1. NEDD8-specific protease activity Source: UniProtKB
  2. cysteine-type peptidase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. transcription coactivator activity Source: UniProtKB
  5. ubiquitin thiolesterase activity Source: UniProtKB
  6. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. histone deubiquitination Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene namesi
Name:Usp21
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1588822. Usp21.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Ubiquitin carboxyl-terminal hydrolase 21
PRO_0000367509Add
BLAST

Proteomic databases

PRIDEiB2GUX4.

Expressioni

Gene expression databases

GenevestigatoriB2GUX4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055192.

Structurei

3D structure databases

ProteinModelPortaliB2GUX4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 558347USP
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 15219Nuclear export signal By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00750000117710.
HOVERGENiHBG011164.
KOiK11833.
OMAiNVQPRVG.
OrthoDBiEOG7FR7GN.
PhylomeDBiB2GUX4.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GUX4-1 [UniParc]FASTAAdd to Basket

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MPQASEHRLG RTREPPVNVQ PRVGAKIPFP PRARSKERRN PVPGPNSMLR    50
PLPPRPGPPD ERLKKLDLGR GRTSGSRPRG PLRADHGVPL PGSPPPTVAL 100
PLPSRTNLTR SKSVSSGDLR PMGIALGGHR GTGELGAALS RLALRPEPPT 150
LRRSTSLRRL GGFPGPPTLL SIRTEPPPSH GSFHMISARP SEPFYSDDKM 200
AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC LRRDFRQEVP 250
GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 300
DAQEFLKLLM ERLHLEINRR GRRAPPILAS GPVPSPPRRG GALHEEPELS 350
DDDRANLMWK RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL 400
SLPIPKKGFA GGKVSLRDCF SLFTKEEELE SENAPVCDRC RQKTRSTKKL 450
TVQRFPRILV LHLNRFSTSR GSIKKSSVGV DFPLQRLSLG DFASDKVGSP 500
VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV SENQVASSEG 550
YVLFYQLMQE PPRCL 565
Length:565
Mass (Da):62,700
Last modified:June 10, 2008 - v1
Checksum:i37ABEBF9CE07E938
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166443 mRNA. Translation: AAI66443.1.
RefSeqiNP_001121110.1. NM_001127638.1.
UniGeneiRn.136743.

Genome annotation databases

EnsembliENSRNOT00000058390; ENSRNOP00000055192; ENSRNOG00000038347.
GeneIDi688466.
KEGGirno:688466.
UCSCiRGD:1588822. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166443 mRNA. Translation: AAI66443.1 .
RefSeqi NP_001121110.1. NM_001127638.1.
UniGenei Rn.136743.

3D structure databases

ProteinModelPortali B2GUX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000055192.

Proteomic databases

PRIDEi B2GUX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000058390 ; ENSRNOP00000055192 ; ENSRNOG00000038347 .
GeneIDi 688466.
KEGGi rno:688466.
UCSCi RGD:1588822. rat.

Organism-specific databases

CTDi 27005.
RGDi 1588822. Usp21.

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00750000117710.
HOVERGENi HBG011164.
KOi K11833.
OMAi NVQPRVG.
OrthoDBi EOG7FR7GN.
PhylomeDBi B2GUX4.

Miscellaneous databases

NextBioi 736555.

Gene expression databases

Genevestigatori B2GUX4.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiUBP21_RAT
AccessioniPrimary (citable) accession number: B2GUX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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