Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B2GUX4

- UBP21_RAT

UniProt

B2GUX4 - UBP21_RAT

Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene

Usp21

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei221 – 2211NucleophilePROSITE-ProRule annotation
    Metal bindingi384 – 3841ZincBy similarity
    Metal bindingi387 – 3871ZincBy similarity
    Metal bindingi437 – 4371ZincBy similarity
    Metal bindingi440 – 4401ZincBy similarity
    Active sitei518 – 5181Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. NEDD8-specific protease activity Source: UniProtKB
    4. transcription coactivator activity Source: UniProtKB
    5. ubiquitin-specific protease activity Source: UniProtKB
    6. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. histone deubiquitination Source: UniProtKB
    2. positive regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 21
    Ubiquitin thioesterase 21
    Ubiquitin-specific-processing protease 21
    Gene namesi
    Name:Usp21
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1588822. Usp21.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Ubiquitin carboxyl-terminal hydrolase 21PRO_0000367509Add
    BLAST

    Proteomic databases

    PRIDEiB2GUX4.

    Expressioni

    Gene expression databases

    GenevestigatoriB2GUX4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000055192.

    Structurei

    3D structure databases

    ProteinModelPortaliB2GUX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini212 – 558347USPAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi134 – 15219Nuclear export signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP21 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00750000117710.
    HOVERGENiHBG011164.
    KOiK11833.
    OMAiNVQPRVG.
    OrthoDBiEOG7FR7GN.
    PhylomeDBiB2GUX4.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2GUX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQASEHRLG RTREPPVNVQ PRVGAKIPFP PRARSKERRN PVPGPNSMLR    50
    PLPPRPGPPD ERLKKLDLGR GRTSGSRPRG PLRADHGVPL PGSPPPTVAL 100
    PLPSRTNLTR SKSVSSGDLR PMGIALGGHR GTGELGAALS RLALRPEPPT 150
    LRRSTSLRRL GGFPGPPTLL SIRTEPPPSH GSFHMISARP SEPFYSDDKM 200
    AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC LRRDFRQEVP 250
    GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 300
    DAQEFLKLLM ERLHLEINRR GRRAPPILAS GPVPSPPRRG GALHEEPELS 350
    DDDRANLMWK RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL 400
    SLPIPKKGFA GGKVSLRDCF SLFTKEEELE SENAPVCDRC RQKTRSTKKL 450
    TVQRFPRILV LHLNRFSTSR GSIKKSSVGV DFPLQRLSLG DFASDKVGSP 500
    VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV SENQVASSEG 550
    YVLFYQLMQE PPRCL 565
    Length:565
    Mass (Da):62,700
    Last modified:June 10, 2008 - v1
    Checksum:i37ABEBF9CE07E938
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166443 mRNA. Translation: AAI66443.1.
    RefSeqiNP_001121110.1. NM_001127638.1.
    UniGeneiRn.136743.

    Genome annotation databases

    EnsembliENSRNOT00000058390; ENSRNOP00000055192; ENSRNOG00000038347.
    GeneIDi688466.
    KEGGirno:688466.
    UCSCiRGD:1588822. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166443 mRNA. Translation: AAI66443.1 .
    RefSeqi NP_001121110.1. NM_001127638.1.
    UniGenei Rn.136743.

    3D structure databases

    ProteinModelPortali B2GUX4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000055192.

    Proteomic databases

    PRIDEi B2GUX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000058390 ; ENSRNOP00000055192 ; ENSRNOG00000038347 .
    GeneIDi 688466.
    KEGGi rno:688466.
    UCSCi RGD:1588822. rat.

    Organism-specific databases

    CTDi 27005.
    RGDi 1588822. Usp21.

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00750000117710.
    HOVERGENi HBG011164.
    KOi K11833.
    OMAi NVQPRVG.
    OrthoDBi EOG7FR7GN.
    PhylomeDBi B2GUX4.

    Miscellaneous databases

    NextBioi 736555.

    Gene expression databases

    Genevestigatori B2GUX4.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiUBP21_RAT
    AccessioniPrimary (citable) accession number: B2GUX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3