Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apoptosis-enhancing nuclease

Gene

Aen

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Apoptosis, DNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-enhancing nucleaseBy similarity (EC:3.1.-.-)
Alternative name(s):
Interferon-stimulated 20 kDa exonuclease-like 1Imported
Gene namesi
Name:AenBy similarity
Synonyms:Isg20l1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305051. Aen.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity

  • Note: Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Apoptosis-enhancing nucleasePRO_0000355124Add
BLAST

Proteomic databases

PaxDbiB2GUW6.
PRIDEiB2GUW6.

Expressioni

Gene expression databases

GenevisibleiB2GUW6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062841.

Structurei

3D structure databases

ProteinModelPortaliB2GUW6.
SMRiB2GUW6. Positions 104-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 261157ExonucleaseSequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 299Nucleolar localization signalBy similarity
Motifi160 – 18324Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 exonuclease domain.Sequence analysis

Phylogenomic databases

eggNOGiKOG2249. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00520000055542.
HOGENOMiHOG000182422.
HOVERGENiHBG100435.
InParanoidiB2GUW6.
KOiK18340.
OMAiSRENEHY.
OrthoDBiEOG7WHHB0.
PhylomeDBiB2GUW6.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

B2GUW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPREVPESS LTSLKTKDVA RRRHKRRSRQ HQRFMARKAL LQEQESLSMV
60 70 80 90 100
PGPGLCPLPS PTQTPAGTEA SGNRKQRTKA RSGSKGLCSK RPVPREAPSS
110 120 130 140 150
GPSKYVAIDC EMVGTGPQGR VSELARCSVV SYSGDVLYDK YIRPEMPIVD
160 170 180 190 200
YRTRWSGITR QHMHKAIPFQ VAQKEILKLL KGKVVVGHAL HNDFQALKYV
210 220 230 240 250
HPGSQIRDTT YVPNLLSQPS SLTRARVSLK DLALNLLHKK IQVGHHGHSS
260 270 280 290 300
VEDAMTAMEL YQLVEVQWEQ QVASTAKAHP EDRGPDSSTD VEQYMDDQYW
310 320 330
PEDLAQSTRG DTREAQDRQE GEEGQGARSA PP
Length:332
Mass (Da):37,061
Last modified:June 10, 2008 - v1
Checksum:iBD5048D7D10C196A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473980 Genomic DNA. Translation: EDM08560.1.
CH473980 Genomic DNA. Translation: EDM08562.1.
BC166435 mRNA. Translation: AAI66435.1.
RefSeqiNP_001101957.1. NM_001108487.2.
XP_006229461.1. XM_006229399.2.
UniGeneiRn.46887.

Genome annotation databases

EnsembliENSRNOT00000064438; ENSRNOP00000062841; ENSRNOG00000018421.
GeneIDi361594.
KEGGirno:361594.
UCSCiRGD:1305051. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473980 Genomic DNA. Translation: EDM08560.1.
CH473980 Genomic DNA. Translation: EDM08562.1.
BC166435 mRNA. Translation: AAI66435.1.
RefSeqiNP_001101957.1. NM_001108487.2.
XP_006229461.1. XM_006229399.2.
UniGeneiRn.46887.

3D structure databases

ProteinModelPortaliB2GUW6.
SMRiB2GUW6. Positions 104-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062841.

Proteomic databases

PaxDbiB2GUW6.
PRIDEiB2GUW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064438; ENSRNOP00000062841; ENSRNOG00000018421.
GeneIDi361594.
KEGGirno:361594.
UCSCiRGD:1305051. rat.

Organism-specific databases

CTDi64782.
RGDi1305051. Aen.

Phylogenomic databases

eggNOGiKOG2249. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00520000055542.
HOGENOMiHOG000182422.
HOVERGENiHBG100435.
InParanoidiB2GUW6.
KOiK18340.
OMAiSRENEHY.
OrthoDBiEOG7WHHB0.
PhylomeDBiB2GUW6.

Miscellaneous databases

NextBioi676841.
PROiB2GUW6.

Gene expression databases

GenevisibleiB2GUW6. RN.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.

Entry informationi

Entry nameiAEN_RAT
AccessioniPrimary (citable) accession number: B2GUW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.