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B2GUV8

- B2GUV8_RAT

UniProt

B2GUV8 - B2GUV8_RAT

Protein
Submitted name:

B-cell CLL/lymphoma 6

Gene

Bcl6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. B cell differentiation Source: Ensembl
    3. cell morphogenesis Source: Ensembl
    4. cellular response to DNA damage stimulus Source: Ensembl
    5. erythrocyte development Source: Ensembl
    6. germinal center formation Source: Ensembl
    7. negative regulation of apoptotic process Source: Ensembl
    8. negative regulation of cell growth Source: Ensembl
    9. negative regulation of cell-matrix adhesion Source: Ensembl
    10. negative regulation of cell proliferation Source: Ensembl
    11. negative regulation of isotype switching to IgE isotypes Source: Ensembl
    12. negative regulation of mast cell cytokine production Source: Ensembl
    13. negative regulation of Rho protein signal transduction Source: Ensembl
    14. negative regulation of T-helper 2 cell differentiation Source: Ensembl
    15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. negative regulation of type 2 immune response Source: Ensembl
    17. positive regulation of apoptotic process Source: Ensembl
    18. positive regulation of B cell proliferation Source: Ensembl
    19. positive regulation of cellular component movement Source: Ensembl
    20. protein import into nucleus, translocation Source: Ensembl
    21. regulation of inflammatory response Source: Ensembl
    22. regulation of memory T cell differentiation Source: Ensembl
    23. regulation of Rho GTPase activity Source: Ensembl
    24. Rho protein signal transduction Source: Ensembl
    25. spermatogenesis Source: Ensembl
    26. type 2 immune response Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    B-cell CLL/lymphoma 6Imported
    Submitted name:
    B-cell leukemia/lymphoma 6 (Predicted)Imported
    Submitted name:
    Protein Bcl6Imported
    Gene namesi
    Name:Bcl6Imported
    Synonyms:Bcl6_predictedImported
    ORF Names:rCG_36575Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi1309345. Bcl6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW
    2. replication fork Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriB2GUV8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002522.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.UniRule annotation
    Contains BTB (POZ) domain.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Zinc-fingerSAAS annotation

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117671.
    HOGENOMiHOG000001556.
    HOVERGENiHBG004831.
    KOiK15618.
    OMAiNECDCRF.
    OrthoDBiEOG7KQ22S.
    TreeFamiTF330912.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2GUV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL    50
    MACSGLFYSI FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG 100
    NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMAPALKPPR EEFLNSRMLM 150
    PHDVMAYRGR EVVENNMPLR NTPGCESRAF APPLYSGLST PPASYPMYSH 200
    LPLSSFLFSD EELRDAPRMP VANPFPKERA LPCDSARPVP NEYSRPTMEV 250
    SPSLCHSNIY SPKEAVPEEA RSDIHYSVTE GPKPAAPSAR HASYFPCDKA 300
    SKEEERPSSE DEIALHFEPP NAPLNRKGLV SPQSPQKSDC QPNSPTESSS 350
    SKNACILQAS GSPPAKSPTD PKACNWKKYK FIVLNSLNQN AKPEGSEQAE 400
    LGRLSPRAYP APPACQPPME PANLDLQSPT KLSASGEDST IPQASRLNNI 450
    VNRSLAGSPR SSSESHSPLY MHPPKCTSCG SQSPQHTEMC LHTAGPTFPE 500
    EMGETQSEYS DSSCENGAFF CNECDCRFSE EASLKRHTLQ THSDKPYKCD 550
    RCQASFRYKG NLASHKTVHT GEKPYRCNIC GAQFNRPANL KTHTRIHSGE 600
    KPYKCETCGA RFVQVAHLRA HVLIHTGEKP YPCEICGTRF RHLQTLKSHL 650
    RIHTGEKPYH CEKCNLHFRH KSQLRLHLRQ KHGAITNTKV QYRVSAADLP 700
    PELPKAC 707
    Length:707
    Mass (Da):78,865
    Last modified:June 10, 2008 - v1
    Checksum:i81967D3F2087EB1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06069229 Genomic DNA. No translation available.
    AABR06069230 Genomic DNA. No translation available.
    BC166425 mRNA. Translation: AAI66425.1.
    CH473999 Genomic DNA. Translation: EDL78099.1.
    RefSeqiNP_001100554.1. NM_001107084.1.
    UniGeneiRn.20571.

    Genome annotation databases

    EnsembliENSRNOT00000002522; ENSRNOP00000002522; ENSRNOG00000001843.
    GeneIDi303836.
    KEGGirno:303836.
    UCSCiRGD:1309345. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06069229 Genomic DNA. No translation available.
    AABR06069230 Genomic DNA. No translation available.
    BC166425 mRNA. Translation: AAI66425.1 .
    CH473999 Genomic DNA. Translation: EDL78099.1 .
    RefSeqi NP_001100554.1. NM_001107084.1.
    UniGenei Rn.20571.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002522 ; ENSRNOP00000002522 ; ENSRNOG00000001843 .
    GeneIDi 303836.
    KEGGi rno:303836.
    UCSCi RGD:1309345. rat.

    Organism-specific databases

    CTDi 604.
    RGDi 1309345. Bcl6.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117671.
    HOGENOMi HOG000001556.
    HOVERGENi HBG004831.
    KOi K15618.
    OMAi NECDCRF.
    OrthoDBi EOG7KQ22S.
    TreeFami TF330912.

    Miscellaneous databases

    NextBioi 652182.
    PROi B2GUV8.

    Gene expression databases

    Genevestigatori B2GUV8.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiB2GUV8_RAT
    AccessioniPrimary (citable) accession number: B2GUV8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3