SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B2GUV8

- B2GUV8_RAT

UniProt

B2GUV8 - B2GUV8_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

B-cell CLL/lymphoma 6

Gene
Bcl6, Bcl6_predicted, rCG_36575
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. B cell differentiation Source: Ensembl
  3. cell morphogenesis Source: Ensembl
  4. cellular response to DNA damage stimulus Source: Ensembl
  5. erythrocyte development Source: Ensembl
  6. germinal center formation Source: Ensembl
  7. negative regulation of apoptotic process Source: Ensembl
  8. negative regulation of cell growth Source: Ensembl
  9. negative regulation of cell-matrix adhesion Source: Ensembl
  10. negative regulation of cell proliferation Source: Ensembl
  11. negative regulation of isotype switching to IgE isotypes Source: Ensembl
  12. negative regulation of mast cell cytokine production Source: Ensembl
  13. negative regulation of Rho protein signal transduction Source: Ensembl
  14. negative regulation of T-helper 2 cell differentiation Source: Ensembl
  15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. negative regulation of type 2 immune response Source: Ensembl
  17. positive regulation of apoptotic process Source: Ensembl
  18. positive regulation of B cell proliferation Source: Ensembl
  19. positive regulation of cellular component movement Source: Ensembl
  20. protein import into nucleus, translocation Source: Ensembl
  21. regulation of inflammatory response Source: Ensembl
  22. regulation of memory T cell differentiation Source: Ensembl
  23. regulation of Rho GTPase activity Source: Ensembl
  24. Rho protein signal transduction Source: Ensembl
  25. spermatogenesis Source: Ensembl
  26. type 2 immune response Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
B-cell CLL/lymphoma 6Imported
Submitted name:
B-cell leukemia/lymphoma 6 (Predicted)Imported
Submitted name:
Protein Bcl6Imported
Gene namesi
Name:Bcl6Imported
Synonyms:Bcl6_predictedImported
ORF Names:rCG_36575Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi1309345. Bcl6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. replication fork Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriB2GUV8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002522.

Family & Domainsi

Sequence similaritiesi

Contains 1 BTB (POZ) domain.UniRule annotation
Contains BTB (POZ) domain.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations, Zinc-fingerSAAS annotations

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117671.
HOGENOMiHOG000001556.
HOVERGENiHBG004831.
KOiK15618.
OMAiNECDCRF.
OrthoDBiEOG7KQ22S.
TreeFamiTF330912.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GUV8-1 [UniParc]FASTAAdd to Basket

« Hide

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL    50
MACSGLFYSI FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG 100
NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMAPALKPPR EEFLNSRMLM 150
PHDVMAYRGR EVVENNMPLR NTPGCESRAF APPLYSGLST PPASYPMYSH 200
LPLSSFLFSD EELRDAPRMP VANPFPKERA LPCDSARPVP NEYSRPTMEV 250
SPSLCHSNIY SPKEAVPEEA RSDIHYSVTE GPKPAAPSAR HASYFPCDKA 300
SKEEERPSSE DEIALHFEPP NAPLNRKGLV SPQSPQKSDC QPNSPTESSS 350
SKNACILQAS GSPPAKSPTD PKACNWKKYK FIVLNSLNQN AKPEGSEQAE 400
LGRLSPRAYP APPACQPPME PANLDLQSPT KLSASGEDST IPQASRLNNI 450
VNRSLAGSPR SSSESHSPLY MHPPKCTSCG SQSPQHTEMC LHTAGPTFPE 500
EMGETQSEYS DSSCENGAFF CNECDCRFSE EASLKRHTLQ THSDKPYKCD 550
RCQASFRYKG NLASHKTVHT GEKPYRCNIC GAQFNRPANL KTHTRIHSGE 600
KPYKCETCGA RFVQVAHLRA HVLIHTGEKP YPCEICGTRF RHLQTLKSHL 650
RIHTGEKPYH CEKCNLHFRH KSQLRLHLRQ KHGAITNTKV QYRVSAADLP 700
PELPKAC 707
Length:707
Mass (Da):78,865
Last modified:June 10, 2008 - v1
Checksum:i81967D3F2087EB1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06069229 Genomic DNA. No translation available.
AABR06069230 Genomic DNA. No translation available.
BC166425 mRNA. Translation: AAI66425.1.
CH473999 Genomic DNA. Translation: EDL78099.1.
RefSeqiNP_001100554.1. NM_001107084.1.
UniGeneiRn.20571.

Genome annotation databases

EnsembliENSRNOT00000002522; ENSRNOP00000002522; ENSRNOG00000001843.
GeneIDi303836.
KEGGirno:303836.
UCSCiRGD:1309345. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06069229 Genomic DNA. No translation available.
AABR06069230 Genomic DNA. No translation available.
BC166425 mRNA. Translation: AAI66425.1 .
CH473999 Genomic DNA. Translation: EDL78099.1 .
RefSeqi NP_001100554.1. NM_001107084.1.
UniGenei Rn.20571.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002522 ; ENSRNOP00000002522 ; ENSRNOG00000001843 .
GeneIDi 303836.
KEGGi rno:303836.
UCSCi RGD:1309345. rat.

Organism-specific databases

CTDi 604.
RGDi 1309345. Bcl6.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117671.
HOGENOMi HOG000001556.
HOVERGENi HBG004831.
KOi K15618.
OMAi NECDCRF.
OrthoDBi EOG7KQ22S.
TreeFami TF330912.

Miscellaneous databases

NextBioi 652182.
PROi B2GUV8.

Gene expression databases

Genevestigatori B2GUV8.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB2GUV8_RAT
AccessioniPrimary (citable) accession number: B2GUV8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi