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B2GUT4

- WNT11_XENTR

UniProt

B2GUT4 - WNT11_XENTR

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Protein

Protein Wnt-11

Gene
wnt11, wnt11r
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors By similarity. Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca2+ By similarity.By similarity

GO - Molecular functioni

  1. protein kinase activator activity Source: UniProtKB
  2. Ras GTPase activator activity Source: UniProtKB
  3. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. cell migration involved in gastrulation Source: Ensembl
  2. dorsal fin development Source: UniProtKB
  3. heart looping Source: Ensembl
  4. heart morphogenesis Source: UniProtKB
  5. negative regulation of apoptotic process Source: UniProtKB
  6. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  7. negative regulation of cell death Source: UniProtKB
  8. negative regulation of cell growth Source: UniProtKB
  9. negative regulation of cell migration Source: UniProtKB
  10. negative regulation of transcription, DNA-templated Source: UniProtKB
  11. neural crest cell migration Source: UniProtKB
  12. neuroendocrine cell differentiation Source: UniProtKB
  13. non-canonical Wnt signaling pathway Source: UniProtKB
  14. palate development Source: UniProtKB
  15. positive regulation of cell migration Source: UniProtKB
  16. positive regulation of gene expression Source: UniProtKB
  17. positive regulation of JNK cascade Source: UniProtKB
  18. positive regulation of protein kinase activity Source: GOC
  19. positive regulation of protein kinase C signaling Source: UniProtKB
  20. positive regulation of Ras GTPase activity Source: UniProtKB
  21. positive regulation of stress fiber assembly Source: UniProtKB
  22. positive regulation of transcription, DNA-templated Source: UniProtKB
  23. pronephros development Source: UniProtKB
  24. protein localization to cell surface Source: UniProtKB
  25. protein phosphorylation Source: UniProtKB
  26. regulation of gastrulation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Gastrulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_217171. PCP/CE pathway.
REACT_220644. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Alternative name(s):
Protein Wnt-11-related
Gene namesi
Name:wnt11
Synonyms:wnt11r
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-854158. wnt11.

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 352330Protein Wnt-11PRO_0000397207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi78 ↔ 89 By similarity
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi128 ↔ 136 By similarity
Disulfide bondi138 ↔ 155 By similarity
Disulfide bondi207 ↔ 221 By similarity
Disulfide bondi209 ↔ 216 By similarity
Lipidationi213 – 2131O-palmitoyl serine; by PORCN By similarity
Modified residuei273 – 2731Sulfotyrosine By similarityBy similarity
Modified residuei280 – 2801Sulfotyrosine By similarityBy similarity
Disulfide bondi297 ↔ 312 By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi327 ↔ 342 By similarity
Disulfide bondi329 ↔ 339 By similarity
Disulfide bondi334 ↔ 335 By similarity

Post-translational modificationi

Glycosylation is required for protein secretion By similarity.By similarity
Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Sulfation

Expressioni

Gene expression databases

BgeeiB2GUT4.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042046.

Structurei

3D structure databases

ProteinModelPortaliB2GUT4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 34236Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
KOiK01384.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GUT4-1 [UniParc]FASTAAdd to Basket

« Hide

MKIYFLLGIF LTFLLHTRIC QGIKWLALAK TPLSLALNQS QHCKQLEGLV    50
SSQMQLCRSN LELMQTIIHA AKEVKKTCIK AFTDMRWNCS SIELAPTFHQ 100
DLERGTRESA FVYALSAAAI SHTIARACTT GDIPGCSCAP IPGESPGPGY 150
RWGGCADNLN YGILMGSKFS DAPMKMKKSG SQANKLMHLH NSEVGRQVLK 200
ASLEMKCKCH GVSGSCSIKT CWRGLQELRE IALDLKTKYL SATKVVHRPM 250
GTRKQLVPKD IDIRPVQETE MIYLQSSPDY CLKNEKMGSH GTHERQCNKT 300
SNGSDSCDLM CCGRGYNPYM DKVVERCHCK YHWCCYVTCK KCERTVERYV 350
CK 352
Length:352
Mass (Da):39,517
Last modified:June 10, 2008 - v1
Checksum:i0DD8ECACF8972D55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166399 mRNA. Translation: AAI66399.1.
RefSeqiNP_001121530.1. NM_001128058.1.
UniGeneiStr.57693.

Genome annotation databases

GeneIDi100158655.
KEGGixtr:100158655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166399 mRNA. Translation: AAI66399.1 .
RefSeqi NP_001121530.1. NM_001128058.1.
UniGenei Str.57693.

3D structure databases

ProteinModelPortali B2GUT4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000042046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100158655.
KEGGi xtr:100158655.

Organism-specific databases

CTDi 30283.
Xenbasei XB-GENE-854158. wnt11.

Phylogenomic databases

eggNOGi NOG273917.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
KOi K01384.

Enzyme and pathway databases

Reactomei REACT_217171. PCP/CE pathway.
REACT_220644. WNT ligand biogenesis and trafficking.

Gene expression databases

Bgeei B2GUT4.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16."
    Garriock R.J., Warkman A.S., Meadows S.M., D'Agostino S., Krieg P.A.
    Dev. Dyn. 236:1249-1258(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiWNT11_XENTR
AccessioniPrimary (citable) accession number: B2GUT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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