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B2GUT4 (WNT11_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-11
Alternative name(s):
Protein Wnt-11-related
Gene names
Name:wnt11
Synonyms:wnt11r
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors By similarity. Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca2+ By similarity. UniProtKB Q670P5

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity UniProtKB Q670P5.

Post-translational modification

Glycosylation is required for protein secretion By similarity. UniProtKB P49893

Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-78. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Miscellaneous

Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals. Ref.2

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processGastrulation
Wnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration involved in gastrulation

Inferred from electronic annotation. Source: Ensembl

dorsal fin development

Inferred from sequence or structural similarity. Source: UniProtKB

heart looping

Inferred from electronic annotation. Source: Ensembl

heart morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

neural crest cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

neuroendocrine cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

non-canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of JNK cascade

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of Ras GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase C signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: GOC

positive regulation of stress fiber assembly

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

pronephros development

Inferred from sequence or structural similarity. Source: UniProtKB

protein localization to cell surface

Inferred from sequence or structural similarity. Source: UniProtKB

protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of gastrulation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular region

Inferred from sequence or structural similarity. Source: UniProtKB

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRas GTPase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein kinase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 352330Protein Wnt-11
PRO_0000397207

Regions

Compositional bias307 – 34236Cys-rich

Amino acid modifications

Modified residue2731Sulfotyrosine By similarity UniProtKB P49893
Modified residue2801Sulfotyrosine By similarity UniProtKB P49893
Lipidation781S-palmitoyl cysteine By similarity
Lipidation2131O-palmitoyl serine; by PORCN By similarity
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B2GUT4 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 0DD8ECACF8972D55

FASTA35239,517
        10         20         30         40         50         60 
MKIYFLLGIF LTFLLHTRIC QGIKWLALAK TPLSLALNQS QHCKQLEGLV SSQMQLCRSN 

        70         80         90        100        110        120 
LELMQTIIHA AKEVKKTCIK AFTDMRWNCS SIELAPTFHQ DLERGTRESA FVYALSAAAI 

       130        140        150        160        170        180 
SHTIARACTT GDIPGCSCAP IPGESPGPGY RWGGCADNLN YGILMGSKFS DAPMKMKKSG 

       190        200        210        220        230        240 
SQANKLMHLH NSEVGRQVLK ASLEMKCKCH GVSGSCSIKT CWRGLQELRE IALDLKTKYL 

       250        260        270        280        290        300 
SATKVVHRPM GTRKQLVPKD IDIRPVQETE MIYLQSSPDY CLKNEKMGSH GTHERQCNKT 

       310        320        330        340        350 
SNGSDSCDLM CCGRGYNPYM DKVVERCHCK YHWCCYVTCK KCERTVERYV CK 

« Hide

References

« Hide 'large scale' references
[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.
[2]"Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16."
Garriock R.J., Warkman A.S., Meadows S.M., D'Agostino S., Krieg P.A.
Dev. Dyn. 236:1249-1258(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC166399 mRNA. Translation: AAI66399.1.
RefSeqNP_001121530.1. NM_001128058.1.
UniGeneStr.57693.

3D structure databases

ProteinModelPortalB2GUT4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000042046.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100158655.
KEGGxtr:100158655.

Organism-specific databases

CTD30283.
XenbaseXB-GENE-854158. wnt11.

Phylogenomic databases

eggNOGNOG273917.
HOGENOMHOG000039529.
HOVERGENHBG001595.
KOK01384.

Gene expression databases

BgeeB2GUT4.

Family and domain databases

InterProIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT11_XENTR
AccessionPrimary (citable) accession number: B2GUT4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families