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B2GUT4

- WNT11_XENTR

UniProt

B2GUT4 - WNT11_XENTR

Protein

Protein Wnt-11

Gene

wnt11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors By similarity. Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca2+ By similarity.By similarity

    GO - Molecular functioni

    1. protein kinase activator activity Source: UniProtKB
    2. Ras GTPase activator activity Source: UniProtKB
    3. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell migration involved in gastrulation Source: Ensembl
    2. dorsal fin development Source: UniProtKB
    3. heart looping Source: Ensembl
    4. heart morphogenesis Source: UniProtKB
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    7. negative regulation of cell death Source: UniProtKB
    8. negative regulation of cell growth Source: UniProtKB
    9. negative regulation of cell migration Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. neural crest cell migration Source: UniProtKB
    12. neuroendocrine cell differentiation Source: UniProtKB
    13. non-canonical Wnt signaling pathway Source: UniProtKB
    14. palate development Source: UniProtKB
    15. positive regulation of cell migration Source: UniProtKB
    16. positive regulation of gene expression Source: UniProtKB
    17. positive regulation of JNK cascade Source: UniProtKB
    18. positive regulation of protein kinase activity Source: GOC
    19. positive regulation of protein kinase C signaling Source: UniProtKB
    20. positive regulation of Ras GTPase activity Source: UniProtKB
    21. positive regulation of stress fiber assembly Source: UniProtKB
    22. positive regulation of transcription, DNA-templated Source: UniProtKB
    23. pronephros development Source: UniProtKB
    24. protein localization to cell surface Source: UniProtKB
    25. protein phosphorylation Source: UniProtKB
    26. regulation of gastrulation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Gastrulation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_217171. PCP/CE pathway.
    REACT_220644. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-111 Publication
    Alternative name(s):
    Protein Wnt-11-relatedBy similarity
    Gene namesi
    Name:wnt11
    Synonyms:wnt11rImported
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-854158. wnt11.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 352330Protein Wnt-11Sequence AnalysisPRO_0000397207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 89By similarity
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 136By similarity
    Disulfide bondi138 ↔ 155By similarity
    Disulfide bondi207 ↔ 221By similarity
    Disulfide bondi209 ↔ 216By similarity
    Lipidationi213 – 2131O-palmitoyl serine; by PORCNBy similarity
    Modified residuei273 – 2731SulfotyrosineBy similarity
    Modified residuei280 – 2801SulfotyrosineBy similarity
    Disulfide bondi297 ↔ 312By similarity
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi327 ↔ 342By similarity
    Disulfide bondi329 ↔ 339By similarity
    Disulfide bondi334 ↔ 335By similarity

    Post-translational modificationi

    Glycosylation is required for protein secretion.By similarity
    Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Sulfation

    Expressioni

    Gene expression databases

    BgeeiB2GUT4.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000042046.

    Structurei

    3D structure databases

    ProteinModelPortaliB2GUT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi307 – 34236Cys-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Wnt family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG273917.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    KOiK01384.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026536. Wnt-11.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF7. PTHR12027:SF7. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B2GUT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIYFLLGIF LTFLLHTRIC QGIKWLALAK TPLSLALNQS QHCKQLEGLV    50
    SSQMQLCRSN LELMQTIIHA AKEVKKTCIK AFTDMRWNCS SIELAPTFHQ 100
    DLERGTRESA FVYALSAAAI SHTIARACTT GDIPGCSCAP IPGESPGPGY 150
    RWGGCADNLN YGILMGSKFS DAPMKMKKSG SQANKLMHLH NSEVGRQVLK 200
    ASLEMKCKCH GVSGSCSIKT CWRGLQELRE IALDLKTKYL SATKVVHRPM 250
    GTRKQLVPKD IDIRPVQETE MIYLQSSPDY CLKNEKMGSH GTHERQCNKT 300
    SNGSDSCDLM CCGRGYNPYM DKVVERCHCK YHWCCYVTCK KCERTVERYV 350
    CK 352
    Length:352
    Mass (Da):39,517
    Last modified:June 10, 2008 - v1
    Checksum:i0DD8ECACF8972D55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166399 mRNA. Translation: AAI66399.1.
    RefSeqiNP_001121530.1. NM_001128058.1.
    UniGeneiStr.57693.

    Genome annotation databases

    GeneIDi100158655.
    KEGGixtr:100158655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166399 mRNA. Translation: AAI66399.1 .
    RefSeqi NP_001121530.1. NM_001128058.1.
    UniGenei Str.57693.

    3D structure databases

    ProteinModelPortali B2GUT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000042046.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100158655.
    KEGGi xtr:100158655.

    Organism-specific databases

    CTDi 30283.
    Xenbasei XB-GENE-854158. wnt11.

    Phylogenomic databases

    eggNOGi NOG273917.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    KOi K01384.

    Enzyme and pathway databases

    Reactomei REACT_217171. PCP/CE pathway.
    REACT_220644. WNT ligand biogenesis and trafficking.

    Gene expression databases

    Bgeei B2GUT4.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026536. Wnt-11.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF7. PTHR12027:SF7. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestineImported.
    2. "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16."
      Garriock R.J., Warkman A.S., Meadows S.M., D'Agostino S., Krieg P.A.
      Dev. Dyn. 236:1249-1258(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiWNT11_XENTR
    AccessioniPrimary (citable) accession number: B2GUT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3