Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Wnt-11

Gene

wnt11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca2+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Gastrulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_272863. PCP/CE pathway.
REACT_306328. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-111 Publication
Alternative name(s):
Protein Wnt-11-relatedBy similarity
Gene namesi
Name:wnt11
Synonyms:wnt11rImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-854158. wnt11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 352330Protein Wnt-11Sequence AnalysisPRO_0000397207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi78 ↔ 89By similarity
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi128 ↔ 136By similarity
Disulfide bondi138 ↔ 155By similarity
Disulfide bondi207 ↔ 221By similarity
Disulfide bondi209 ↔ 216By similarity
Lipidationi213 – 2131O-palmitoleyl serine; by PORCNBy similarity
Modified residuei273 – 2731SulfotyrosineBy similarity
Modified residuei280 – 2801SulfotyrosineBy similarity
Disulfide bondi297 ↔ 312By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi327 ↔ 342By similarity
Disulfide bondi329 ↔ 339By similarity
Disulfide bondi334 ↔ 335By similarity

Post-translational modificationi

Glycosylation is required for protein secretion.By similarity
Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Sulfation

Expressioni

Gene expression databases

BgeeiB2GUT4.
ExpressionAtlasiB2GUT4. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042046.

Structurei

3D structure databases

ProteinModelPortaliB2GUT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 34236Cys-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the Wnt family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiB2GUT4.
KOiK01384.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GUT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYFLLGIF LTFLLHTRIC QGIKWLALAK TPLSLALNQS QHCKQLEGLV
60 70 80 90 100
SSQMQLCRSN LELMQTIIHA AKEVKKTCIK AFTDMRWNCS SIELAPTFHQ
110 120 130 140 150
DLERGTRESA FVYALSAAAI SHTIARACTT GDIPGCSCAP IPGESPGPGY
160 170 180 190 200
RWGGCADNLN YGILMGSKFS DAPMKMKKSG SQANKLMHLH NSEVGRQVLK
210 220 230 240 250
ASLEMKCKCH GVSGSCSIKT CWRGLQELRE IALDLKTKYL SATKVVHRPM
260 270 280 290 300
GTRKQLVPKD IDIRPVQETE MIYLQSSPDY CLKNEKMGSH GTHERQCNKT
310 320 330 340 350
SNGSDSCDLM CCGRGYNPYM DKVVERCHCK YHWCCYVTCK KCERTVERYV

CK
Length:352
Mass (Da):39,517
Last modified:June 10, 2008 - v1
Checksum:i0DD8ECACF8972D55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166399 mRNA. Translation: AAI66399.1.
RefSeqiNP_001121530.1. NM_001128058.1.
UniGeneiStr.57693.

Genome annotation databases

GeneIDi100158655.
KEGGixtr:100158655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166399 mRNA. Translation: AAI66399.1.
RefSeqiNP_001121530.1. NM_001128058.1.
UniGeneiStr.57693.

3D structure databases

ProteinModelPortaliB2GUT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100158655.
KEGGixtr:100158655.

Organism-specific databases

CTDi30283.
XenbaseiXB-GENE-854158. wnt11.

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiB2GUT4.
KOiK01384.

Enzyme and pathway databases

ReactomeiREACT_272863. PCP/CE pathway.
REACT_306328. WNT ligand biogenesis and trafficking.

Gene expression databases

BgeeiB2GUT4.
ExpressionAtlasiB2GUT4. baseline.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestineImported.
  2. "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16."
    Garriock R.J., Warkman A.S., Meadows S.M., D'Agostino S., Krieg P.A.
    Dev. Dyn. 236:1249-1258(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiWNT11_XENTR
AccessioniPrimary (citable) accession number: B2GUT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 10, 2008
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.