B2GUT4 (WNT11_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-11

Alternative name(s):
Protein Wnt-11-related

Gene names

Name:	wnt11
Synonyms:	wnt11r

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors By similarity. Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca2+ By similarity. UniProtKB Q670P5
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity UniProtKB Q670P5.
Post-translational modification	Glycosylation is required for protein secretion By similarity. UniProtKB P49893 Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-78. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Miscellaneous	Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals. Ref.2
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Gastrulation Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration involved in gastrulation Inferred from electronic annotation. Source: Compara dorsal fin development Inferred from sequence or structural similarity. Source: UniProtKB heart morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell growth Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB neural crest cell migration Inferred from sequence or structural similarity. Source: UniProtKB neuroendocrine cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB non-canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB palate development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of JNK cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein kinase C signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of stress fiber assembly Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB pronephros development Inferred from sequence or structural similarity. Source: UniProtKB protein localization to cell surface Inferred from sequence or structural similarity. Source: UniProtKB protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB regulation of gastrulation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB extracellular region Inferred from sequence or structural similarity. Source: UniProtKB proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	Ras GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB protein kinase activator activity Inferred from sequence or structural similarity. Source: UniProtKB transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 352	330	Protein Wnt-11		PRO_0000397207
Regions
	Compositional bias	307 – 342	36	Cys-rich
Amino acid modifications
	Modified residue	273	1	Sulfotyrosine By similarity UniProtKB P49893
	Modified residue	280	1	Sulfotyrosine By similarity UniProtKB P49893
	Lipidation	78	1	S-palmitoyl cysteine By similarity
	Lipidation	213	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	B2GUT4 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 0DD8ECACF8972D55	FASTA	352	39,517
	10 20 30 40 50 60 MKIYFLLGIF LTFLLHTRIC QGIKWLALAK TPLSLALNQS QHCKQLEGLV SSQMQLCRSN 70 80 90 100 110 120 LELMQTIIHA AKEVKKTCIK AFTDMRWNCS SIELAPTFHQ DLERGTRESA FVYALSAAAI 130 140 150 160 170 180 SHTIARACTT GDIPGCSCAP IPGESPGPGY RWGGCADNLN YGILMGSKFS DAPMKMKKSG 190 200 210 220 230 240 SQANKLMHLH NSEVGRQVLK ASLEMKCKCH GVSGSCSIKT CWRGLQELRE IALDLKTKYL 250 260 270 280 290 300 SATKVVHRPM GTRKQLVPKD IDIRPVQETE MIYLQSSPDY CLKNEKMGSH GTHERQCNKT 310 320 330 340 350 SNGSDSCDLM CCGRGYNPYM DKVVERCHCK YHWCCYVTCK KCERTVERYV CK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
[2]	"Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16." Garriock R.J., Warkman A.S., Meadows S.M., D'Agostino S., Krieg P.A. Dev. Dyn. 236:1249-1258(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC166399 mRNA. Translation: AAI66399.1.
RefSeq	NP_001121530.1. NM_001128058.1.
UniGene	Str.57693.
3D structure databases
ProteinModelPortal	B2GUT4.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000042046.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100158655.
KEGG	xtr:100158655.
Organism-specific databases
CTD	30283.
Xenbase	XB-GENE-854158. wnt11.
Phylogenomic databases
eggNOG	NOG273917.
HOGENOM	HOG000039529.
HOVERGEN	HBG001595.
KO	K01384.
OrthoDB	EOG4FR0RT.
Gene expression databases
Bgee	B2GUT4.
Family and domain databases
InterPro	IPR005817. Wnt. IPR026536. Wnt-11. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF7. PTHR12027:SF7. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

WNT11_XENTR

Accession

Primary (citable) accession number: B2GUT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 10, 2010
Last sequence update:	June 10, 2008
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program