casp3

Functionⁱ

GO - Molecular functionⁱ

cysteine-type endopeptidase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

apoptotic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.003.

MEROPSⁱ

C14.003.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Casp3 proteinImported
Gene namesⁱ	Name:casp3Imported
Organismⁱ	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifierⁱ	8364 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Organism-specific databases

Xenbaseⁱ	XB-GENE-479960. casp3.

Xenbaseⁱ

XB-GENE-479960. casp3.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	B2GUM6.

PaxDbⁱ

B2GUM6.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B2GUM6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	54 – 178	CASPASE_P20InterPro annotationAdd BLAST		125
Domainⁱ	194 – 288	CASPASE_P10InterPro annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3573. Eukaryota. ENOG410ZQIE. LUCA.
HOGENOMⁱ	HOG000231878.
HOVERGENⁱ	HBG050802.
KEGG Orthology (KO) More...KOⁱ	K02187.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B2GUM6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEESHNGVQY GEDTADAKTY FTNQQISLQN CDIKDMEKKT KFAHLHKYRT 
        60         70         80         90        100
DYPEMGICLI INNKNFQSST NMGVRNGTDV DARKLHETFT GLGYKVKVCN 
       110        120        130        140        150
DQKSNDIFTL LKKMSEEDHS KRSSFVCAIL SHGEDGLVYG VDGPIQIKNL 
       160        170        180        190        200
TDLFRGDRCK TLVGKPKLFF IQACRGTDLD SGIETDSGSE LGEEIQRIPV 
       210        220        230        240        250
EADFLYAYST VPGYYSWRNT MNGSWFIQSL CEMIKLYGPH LELIQILTCV 
       260        270        280 
NHMVALEFES CSTQQAFHAK KQIPCVVSML TKAFYFLK

Length:288

Mass (Da):32,719

Last modified:June 10, 2008 - v1

Checksum:ⁱ78AD2406EE5D0969

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC166338 mRNA. Translation: AAI66338.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001120900.1. NM_001127428.1.
UniGeneⁱ	Str.11713.

Genome annotation databases

GeneIDⁱ	100151728.
KEGGⁱ	xtr:100151728.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC166338 mRNA. Translation: AAI66338.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001120900.1. NM_001127428.1.
UniGeneⁱ	Str.11713.

3D structure databases

ProteinModelPortalⁱ	B2GUM6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.003.

MEROPSⁱ

C14.003.

Proteomic databases

PaxDbⁱ	B2GUM6.

PaxDbⁱ

B2GUM6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100151728.
KEGGⁱ	xtr:100151728.

Organism-specific databases

CTDⁱ	836.
Xenbaseⁱ	XB-GENE-479960. casp3.

Phylogenomic databases

eggNOGⁱ	KOG3573. Eukaryota. ENOG410ZQIE. LUCA.
HOGENOMⁱ	HOG000231878.
HOVERGENⁱ	HBG050802.
KEGG Orthology (KO) More...KOⁱ	K02187.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2GUM6_XENTR
Accessionⁱ	B2GUM6Primary (citable) accession number: B2GUM6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	July 5, 2017
	This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - B2GUM6 (B2GUM6_XENTR)

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Casp3 protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Protein family/group databases

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2GUM6 (B2GUM6_XENTR)

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Casp3 protein

casp3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ