B2GLU6 (AROA_KOCRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	KRH_09400

Organism

Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) [Complete proteome] [HAMAP]

Taxonomic identifier

378753 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Kocuria

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000189564

Sequences

	Sequence		Length	Mass (Da)
	B2GLU6 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: DA571E71477D37C8	FASTA	445	46,445
	10 20 30 40 50 60 MTRNGLSHAQ DDLWPAPFRH GSPVSGTVAV PGSKSLTNRY LVLAALASEP SLVRRPLHSR 70 80 90 100 110 120 DSALMVAALQ TLGAAVTPLP DPGPFGPDLR IDPVRRSAPA ADPVRIDCGL AGTVMRFVPP 130 140 150 160 170 180 LAALHTGQVD FDGDDAARVR PMGPVLDGLR QLGVHVVDQG RAALPFRVLG TGSVPGGTVT 190 200 210 220 230 240 IDASGSSQFV SALLLAAVRF DSPLVLRHDA PGGVPSLPHV EMTLQVLRDA GVDARRVDER 250 260 270 280 290 300 SWRVVPGDVA GLDVTVEPDL SNAGPFLAAA VATGGTVSIP DWPQHTTQGG DHWRHILPRF 310 320 330 340 350 360 GADVTLREGV FTVTGPRELR GVDLDLSEAG ELAPTVAALC ALASGPSRLR GIAHLRGHET 370 380 390 400 410 420 DRLAALSTEL NGLGGAVTET LDGLAIEPTA LHGGVFHTYQ DHRMATAGAI LGLRVPGVQV 430 440 ADIATTAKTL PEFPRMWAEL VGSEG

References

[1]

"Complete genome sequence of the soil actinomycete Kocuria rhizophila." Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S., Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. J. Bacteriol. 190:4139-4146(2008) [PubMed: 18408034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009152 Genomic DNA. Translation: BAG29287.1.
RefSeq	YP_001854793.1. NC_010617.1.
3D structure databases
ProteinModelPortal	B2GLU6.
ModBase	Search...
Protein-protein interaction databases
STRING	B2GLU6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6238254.
GenomeReviews	Gene locus KRH_09400 in contig AP009152_GR.
KEGG	krh:KRH_09400.
PATRIC	22182088. VBIKocRhi5258_0912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	HRMATAG.
ProtClustDB	PRK02427.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_KOCRD

Accession

Primary (citable) accession number: B2GLU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program