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B2GL27

- GSA_KOCRD

UniProt

B2GL27 - GSA_KOCRD

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciKRHI378753:GJ8F-872-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:KRH_08560
    OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
    Taxonomic identifieri378753 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria
    ProteomesiUP000008838: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000121899Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi378753.KRH_08560.

    Structurei

    3D structure databases

    ProteinModelPortaliB2GL27.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRFMVSGN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2GL27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSQELFDR ARRVMPGGVN SPVRAFNSVG GTPPFIAAAK GPYLTDVDGR    50
    EYVDLVCSWG PALIGHAHPV VTEAVHEAVE RGLGFGATTR GETELAELVV 100
    DRVAPLEEIR MVSTGTEATM TALRLARGYT GRDLVVKFAG CYHGHVDSLL 150
    SEAGSGLATL ALPGSAGVTE ATAAQTLVLP YNDVAALEAA FAEHPGRIAA 200
    VITEAAPCNM GVVTPQDGFN AAIRRITQAD GALMILDEVL TGFRVHEAGY 250
    WGLSNAAGES WAPDLFTFGK VIGGGLPTAA LGGRREVMEY LAPTGPVYQA 300
    GTLSGNPVAM AAGLATLKCA DAVAYQTIDR RSEQLRAGLR EALDAAGVDY 350
    SIQEVGSLFS LAFGTRSTGV HDYADAKGQE AFRYTPFFHA MLDAGVYLPP 400
    SVFEAWFLSA AHDDSAMDRI LSALPAAARA AAEAQPPQP 439
    Length:439
    Mass (Da):45,950
    Last modified:June 10, 2008 - v1
    Checksum:i9D0E89A826ADDC97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009152 Genomic DNA. Translation: BAG29203.1.
    RefSeqiYP_001854709.1. NC_010617.1.

    Genome annotation databases

    EnsemblBacteriaiBAG29203; BAG29203; KRH_08560.
    GeneIDi6239487.
    KEGGikrh:KRH_08560.
    PATRICi22181926. VBIKocRhi5258_0832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009152 Genomic DNA. Translation: BAG29203.1 .
    RefSeqi YP_001854709.1. NC_010617.1.

    3D structure databases

    ProteinModelPortali B2GL27.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 378753.KRH_08560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG29203 ; BAG29203 ; KRH_08560 .
    GeneIDi 6239487.
    KEGGi krh:KRH_08560.
    PATRICi 22181926. VBIKocRhi5258_0832.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RFMVSGN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci KRHI378753:GJ8F-872-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

    Entry informationi

    Entry nameiGSA_KOCRD
    AccessioniPrimary (citable) accession number: B2GL27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3