B2GL26 (B2GL26_KOCRD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL BAG29202.1
Ordered Locus Names:	KRH_08550

Organism

Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) [Complete proteome] [HAMAP]

Taxonomic identifier

378753 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Kocuria

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515 EMBL BAG29202.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	202	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	254	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	239	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	212	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	223	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	280	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	319	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	B2GL26 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 2FE234AF9160CEB3	FASTA	334	36,216
	10 20 30 40 50 60 MNDDVSYDLV SRPRRLRSTP AMRRFVAETR VDPSDLILPV FVREGLSEPQ PLSSMPGVVQ 70 80 90 100 110 120 HSMDSLRRAA AEAVELGLGG FMIFGVPETR DAEGSAALDP DGILNRGIRA VREEVGDGVV 130 140 150 160 170 180 VMADLCLDEF TDHGHCGVLD ARGRVDNDRT LEIYGRMAVA QAEAGAHMLG PSGMMDGQVG 190 200 210 220 230 240 VIRAALDAAG HEDVSILAYT AKYSSAFYGP FREAVDSTLT GDRKTYQMDP ANRREALLEL 250 260 270 280 290 300 QTDLAEGADM VMVKPAMSYL DILREIADAS PVPVSAYQIS GEYAMIEAAS ANGWIDREAA 310 320 330 IRESVLSIKR AGADSILTYY ATELAGWLRR ENGR

References

[1]

"Complete genome sequence of the soil actinomycete Kocuria rhizophila." Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S., Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. J. Bacteriol. 190:4139-4146(2008) [PubMed: 18408034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009152 Genomic DNA. Translation: BAG29202.1.
RefSeq	YP_001854708.1. NC_010617.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2GL26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6238183.
GenomeReviews	Gene locus KRH_08550 in contig AP009152_GR.
KEGG	krh:KRH_08550.
PATRIC	22181924. VBIKocRhi5258_0831.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	FTSHGHD.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2GL26_KOCRD

Accession

Primary (citable) accession number: B2GL26

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)