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B2GKR5

- IF2_KOCRD

UniProt

B2GKR5 - IF2_KOCRD

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Protein
Translation initiation factor IF-2
Gene
infB, KRH_16040
Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi469 – 4768GTP By similarity
Nucleotide bindingi519 – 5235GTP By similarity
Nucleotide bindingi573 – 5764GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRHI378753:GJ8F-1644-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:KRH_16040
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria
ProteomesiUP000008838: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Translation initiation factor IF-2UniRule annotation
PRO_1000093795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi378753.KRH_16040.

Structurei

3D structure databases

ProteinModelPortaliB2GKR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini460 – 632173tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni469 – 4768G1 By similarity
Regioni494 – 4985G2 By similarity
Regioni519 – 5224G3 By similarity
Regioni573 – 5764G4 By similarity
Regioni609 – 6113G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GKR5-1 [UniParc]FASTAAdd to Basket

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MAKPRVHELA KELGITSKEA ISKLQELGEF VRGASSTVEP PVAKKLRTAF    50
PAGGDSAPAA KPAAKAPAQG VKKPAAAGPK PGAKAPAKPA ASGNAARAEK 100
PAASEAPKAA AASSEAPKSA APQQGTAPAA ASESSAPGTP ASSAPRPGGA 150
TPGPRKSPAP GAKPGQSAPR PGNNPFASQQ GMGRSEGGAQ RGGPRPGGQQ 200
RSGKPGAPRP GNNPFAAQQG MRSANSGQGG PRPGGPRPGG PRPAQSGQGG 250
PRPGAPRTGA PRQGQGGPRP GGPRPSPNMM PGQTTSVAPI GSRPAPGSGP 300
RRGGGPGGGP GGGGGFRGRG GRGGTQGAFG RGGARGKHRK SKRAKRQELE 350
QMSAPAVGGV SVPHGDGSTV VRLRRGASLM DFAEKINANP ASLVTVLIHL 400
GEMATQTQSL DEETFQLLGA ELGYQIQVVS PEDEERELLE SFDIDLDAEL 450
EAEGEDVLAP RPPVVTVMGH VDHGKTRLLD AIRNTKVIEG EAGGITQHIG 500
AYQISTEVDG QERLITFIDT PGHEAFTAMR ARGAQVTDIA VLVVAADDGV 550
MPQTVEALNH AQAANVPIVV AVNKVDKPDA NPDKIRGQLT EYGLVPEEYG 600
GDTMFVDVSA RENLNIDELL DAIVLTADGA LELQATPDKN ARGVAIEANL 650
DKGRGAVCTV LVQSGTLKVG DSIVAGAAYG RVRAMFDEMG RTVEAATPSR 700
PVQVLGLSTV PRAGDTFLAT QEERTARQIA EKREAADRNA QLAKRRKRIT 750
LESFDEAVAE GKIDTLNLII KGDVSGAVEA LEDSLLKIDV GEEVQLRVIH 800
RGVGAITQND VNLATVDNAV IIGFNVRPAE RVTELADREG VEMKFYSVIY 850
NAIDEVESAL KGMLKPEYEE VELGTAEIRE VFRSSKWGNI AGAYVTKGLI 900
RRNGKARLVR DGNVVQDNLS IDSLRRFKDD ATEVREGYEC GIGLGSFNDI 950
HEGDIIETWE MREKPRD 967
Length:967
Mass (Da):100,648
Last modified:June 10, 2008 - v1
Checksum:i92F334A6CAF5FF93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009152 Genomic DNA. Translation: BAG29951.1.
RefSeqiYP_001855457.1. NC_010617.1.

Genome annotation databases

EnsemblBacteriaiBAG29951; BAG29951; KRH_16040.
GeneIDi6239780.
KEGGikrh:KRH_16040.
PATRICi22183508. VBIKocRhi5258_1601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009152 Genomic DNA. Translation: BAG29951.1 .
RefSeqi YP_001855457.1. NC_010617.1.

3D structure databases

ProteinModelPortali B2GKR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 378753.KRH_16040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG29951 ; BAG29951 ; KRH_16040 .
GeneIDi 6239780.
KEGGi krh:KRH_16040.
PATRICi 22183508. VBIKocRhi5258_1601.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci KRHI378753:GJ8F-1644-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

Entry informationi

Entry nameiIF2_KOCRD
AccessioniPrimary (citable) accession number: B2GKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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