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B2GKR5 (IF2_KOCRD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:KRH_16040
OrganismKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) [Complete proteome] [HAMAP]
Taxonomic identifier378753 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria

Protein attributes

Sequence length967 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 967967Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000093795

Regions

Nucleotide binding469 – 4768GTP By similarity
Nucleotide binding519 – 5235GTP By similarity
Nucleotide binding573 – 5764GTP By similarity
Region463 – 615153G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
B2GKR5 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 92F334A6CAF5FF93

FASTA967100,648
        10         20         30         40         50         60 
MAKPRVHELA KELGITSKEA ISKLQELGEF VRGASSTVEP PVAKKLRTAF PAGGDSAPAA 

        70         80         90        100        110        120 
KPAAKAPAQG VKKPAAAGPK PGAKAPAKPA ASGNAARAEK PAASEAPKAA AASSEAPKSA 

       130        140        150        160        170        180 
APQQGTAPAA ASESSAPGTP ASSAPRPGGA TPGPRKSPAP GAKPGQSAPR PGNNPFASQQ 

       190        200        210        220        230        240 
GMGRSEGGAQ RGGPRPGGQQ RSGKPGAPRP GNNPFAAQQG MRSANSGQGG PRPGGPRPGG 

       250        260        270        280        290        300 
PRPAQSGQGG PRPGAPRTGA PRQGQGGPRP GGPRPSPNMM PGQTTSVAPI GSRPAPGSGP 

       310        320        330        340        350        360 
RRGGGPGGGP GGGGGFRGRG GRGGTQGAFG RGGARGKHRK SKRAKRQELE QMSAPAVGGV 

       370        380        390        400        410        420 
SVPHGDGSTV VRLRRGASLM DFAEKINANP ASLVTVLIHL GEMATQTQSL DEETFQLLGA 

       430        440        450        460        470        480 
ELGYQIQVVS PEDEERELLE SFDIDLDAEL EAEGEDVLAP RPPVVTVMGH VDHGKTRLLD 

       490        500        510        520        530        540 
AIRNTKVIEG EAGGITQHIG AYQISTEVDG QERLITFIDT PGHEAFTAMR ARGAQVTDIA 

       550        560        570        580        590        600 
VLVVAADDGV MPQTVEALNH AQAANVPIVV AVNKVDKPDA NPDKIRGQLT EYGLVPEEYG 

       610        620        630        640        650        660 
GDTMFVDVSA RENLNIDELL DAIVLTADGA LELQATPDKN ARGVAIEANL DKGRGAVCTV 

       670        680        690        700        710        720 
LVQSGTLKVG DSIVAGAAYG RVRAMFDEMG RTVEAATPSR PVQVLGLSTV PRAGDTFLAT 

       730        740        750        760        770        780 
QEERTARQIA EKREAADRNA QLAKRRKRIT LESFDEAVAE GKIDTLNLII KGDVSGAVEA 

       790        800        810        820        830        840 
LEDSLLKIDV GEEVQLRVIH RGVGAITQND VNLATVDNAV IIGFNVRPAE RVTELADREG 

       850        860        870        880        890        900 
VEMKFYSVIY NAIDEVESAL KGMLKPEYEE VELGTAEIRE VFRSSKWGNI AGAYVTKGLI 

       910        920        930        940        950        960 
RRNGKARLVR DGNVVQDNLS IDSLRRFKDD ATEVREGYEC GIGLGSFNDI HEGDIIETWE 


MREKPRD 

« Hide

References

[1]"Complete genome sequence of the soil actinomycete Kocuria rhizophila."
Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S., Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
J. Bacteriol. 190:4139-4146(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009152 Genomic DNA. Translation: BAG29951.1.
RefSeqYP_001855457.1. NC_010617.1.

3D structure databases

ProteinModelPortalB2GKR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING378753.KRH_16040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG29951; BAG29951; KRH_16040.
GeneID6239780.
KEGGkrh:KRH_16040.
PATRIC22183508. VBIKocRhi5258_1601.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMANPDMDAQ.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycKRHI378753:GJ8F-1644-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_KOCRD
AccessionPrimary (citable) accession number: B2GKR5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries