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B2GKR5

- IF2_KOCRD

UniProt

B2GKR5 - IF2_KOCRD

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi469 – 4768GTPUniRule annotation
Nucleotide bindingi519 – 5235GTPUniRule annotation
Nucleotide bindingi573 – 5764GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRHI378753:GJ8F-1644-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:KRH_16040
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria
ProteomesiUP000008838: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Translation initiation factor IF-2PRO_1000093795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi378753.KRH_16040.

Structurei

3D structure databases

ProteinModelPortaliB2GKR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini460 – 632173tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni469 – 4768G1By similarity
Regioni494 – 4985G2By similarity
Regioni519 – 5224G3By similarity
Regioni573 – 5764G4By similarity
Regioni609 – 6113G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GKR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKPRVHELA KELGITSKEA ISKLQELGEF VRGASSTVEP PVAKKLRTAF
60 70 80 90 100
PAGGDSAPAA KPAAKAPAQG VKKPAAAGPK PGAKAPAKPA ASGNAARAEK
110 120 130 140 150
PAASEAPKAA AASSEAPKSA APQQGTAPAA ASESSAPGTP ASSAPRPGGA
160 170 180 190 200
TPGPRKSPAP GAKPGQSAPR PGNNPFASQQ GMGRSEGGAQ RGGPRPGGQQ
210 220 230 240 250
RSGKPGAPRP GNNPFAAQQG MRSANSGQGG PRPGGPRPGG PRPAQSGQGG
260 270 280 290 300
PRPGAPRTGA PRQGQGGPRP GGPRPSPNMM PGQTTSVAPI GSRPAPGSGP
310 320 330 340 350
RRGGGPGGGP GGGGGFRGRG GRGGTQGAFG RGGARGKHRK SKRAKRQELE
360 370 380 390 400
QMSAPAVGGV SVPHGDGSTV VRLRRGASLM DFAEKINANP ASLVTVLIHL
410 420 430 440 450
GEMATQTQSL DEETFQLLGA ELGYQIQVVS PEDEERELLE SFDIDLDAEL
460 470 480 490 500
EAEGEDVLAP RPPVVTVMGH VDHGKTRLLD AIRNTKVIEG EAGGITQHIG
510 520 530 540 550
AYQISTEVDG QERLITFIDT PGHEAFTAMR ARGAQVTDIA VLVVAADDGV
560 570 580 590 600
MPQTVEALNH AQAANVPIVV AVNKVDKPDA NPDKIRGQLT EYGLVPEEYG
610 620 630 640 650
GDTMFVDVSA RENLNIDELL DAIVLTADGA LELQATPDKN ARGVAIEANL
660 670 680 690 700
DKGRGAVCTV LVQSGTLKVG DSIVAGAAYG RVRAMFDEMG RTVEAATPSR
710 720 730 740 750
PVQVLGLSTV PRAGDTFLAT QEERTARQIA EKREAADRNA QLAKRRKRIT
760 770 780 790 800
LESFDEAVAE GKIDTLNLII KGDVSGAVEA LEDSLLKIDV GEEVQLRVIH
810 820 830 840 850
RGVGAITQND VNLATVDNAV IIGFNVRPAE RVTELADREG VEMKFYSVIY
860 870 880 890 900
NAIDEVESAL KGMLKPEYEE VELGTAEIRE VFRSSKWGNI AGAYVTKGLI
910 920 930 940 950
RRNGKARLVR DGNVVQDNLS IDSLRRFKDD ATEVREGYEC GIGLGSFNDI
960
HEGDIIETWE MREKPRD
Length:967
Mass (Da):100,648
Last modified:June 10, 2008 - v1
Checksum:i92F334A6CAF5FF93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA. Translation: BAG29951.1.
RefSeqiYP_001855457.1. NC_010617.1.

Genome annotation databases

EnsemblBacteriaiBAG29951; BAG29951; KRH_16040.
GeneIDi6239780.
KEGGikrh:KRH_16040.
PATRICi22183508. VBIKocRhi5258_1601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA. Translation: BAG29951.1 .
RefSeqi YP_001855457.1. NC_010617.1.

3D structure databases

ProteinModelPortali B2GKR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 378753.KRH_16040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG29951 ; BAG29951 ; KRH_16040 .
GeneIDi 6239780.
KEGGi krh:KRH_16040.
PATRICi 22183508. VBIKocRhi5258_1601.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci KRHI378753:GJ8F-1644-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

Entry informationi

Entry nameiIF2_KOCRD
AccessioniPrimary (citable) accession number: B2GKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3