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B2GKR5

- IF2_KOCRD

UniProt

B2GKR5 - IF2_KOCRD

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi469 – 4768GTPUniRule annotation
    Nucleotide bindingi519 – 5235GTPUniRule annotation
    Nucleotide bindingi573 – 5764GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciKRHI378753:GJ8F-1644-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:KRH_16040
    OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
    Taxonomic identifieri378753 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria
    ProteomesiUP000008838: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 967967Translation initiation factor IF-2PRO_1000093795Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi378753.KRH_16040.

    Structurei

    3D structure databases

    ProteinModelPortaliB2GKR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini460 – 632173tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni469 – 4768G1By similarity
    Regioni494 – 4985G2By similarity
    Regioni519 – 5224G3By similarity
    Regioni573 – 5764G4By similarity
    Regioni609 – 6113G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiNPDMDAQ.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2GKR5-1 [UniParc]FASTAAdd to Basket

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    MAKPRVHELA KELGITSKEA ISKLQELGEF VRGASSTVEP PVAKKLRTAF    50
    PAGGDSAPAA KPAAKAPAQG VKKPAAAGPK PGAKAPAKPA ASGNAARAEK 100
    PAASEAPKAA AASSEAPKSA APQQGTAPAA ASESSAPGTP ASSAPRPGGA 150
    TPGPRKSPAP GAKPGQSAPR PGNNPFASQQ GMGRSEGGAQ RGGPRPGGQQ 200
    RSGKPGAPRP GNNPFAAQQG MRSANSGQGG PRPGGPRPGG PRPAQSGQGG 250
    PRPGAPRTGA PRQGQGGPRP GGPRPSPNMM PGQTTSVAPI GSRPAPGSGP 300
    RRGGGPGGGP GGGGGFRGRG GRGGTQGAFG RGGARGKHRK SKRAKRQELE 350
    QMSAPAVGGV SVPHGDGSTV VRLRRGASLM DFAEKINANP ASLVTVLIHL 400
    GEMATQTQSL DEETFQLLGA ELGYQIQVVS PEDEERELLE SFDIDLDAEL 450
    EAEGEDVLAP RPPVVTVMGH VDHGKTRLLD AIRNTKVIEG EAGGITQHIG 500
    AYQISTEVDG QERLITFIDT PGHEAFTAMR ARGAQVTDIA VLVVAADDGV 550
    MPQTVEALNH AQAANVPIVV AVNKVDKPDA NPDKIRGQLT EYGLVPEEYG 600
    GDTMFVDVSA RENLNIDELL DAIVLTADGA LELQATPDKN ARGVAIEANL 650
    DKGRGAVCTV LVQSGTLKVG DSIVAGAAYG RVRAMFDEMG RTVEAATPSR 700
    PVQVLGLSTV PRAGDTFLAT QEERTARQIA EKREAADRNA QLAKRRKRIT 750
    LESFDEAVAE GKIDTLNLII KGDVSGAVEA LEDSLLKIDV GEEVQLRVIH 800
    RGVGAITQND VNLATVDNAV IIGFNVRPAE RVTELADREG VEMKFYSVIY 850
    NAIDEVESAL KGMLKPEYEE VELGTAEIRE VFRSSKWGNI AGAYVTKGLI 900
    RRNGKARLVR DGNVVQDNLS IDSLRRFKDD ATEVREGYEC GIGLGSFNDI 950
    HEGDIIETWE MREKPRD 967
    Length:967
    Mass (Da):100,648
    Last modified:June 10, 2008 - v1
    Checksum:i92F334A6CAF5FF93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009152 Genomic DNA. Translation: BAG29951.1.
    RefSeqiYP_001855457.1. NC_010617.1.

    Genome annotation databases

    EnsemblBacteriaiBAG29951; BAG29951; KRH_16040.
    GeneIDi6239780.
    KEGGikrh:KRH_16040.
    PATRICi22183508. VBIKocRhi5258_1601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009152 Genomic DNA. Translation: BAG29951.1 .
    RefSeqi YP_001855457.1. NC_010617.1.

    3D structure databases

    ProteinModelPortali B2GKR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 378753.KRH_16040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG29951 ; BAG29951 ; KRH_16040 .
    GeneIDi 6239780.
    KEGGi krh:KRH_16040.
    PATRICi 22183508. VBIKocRhi5258_1601.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi NPDMDAQ.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci KRHI378753:GJ8F-1644-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

    Entry informationi

    Entry nameiIF2_KOCRD
    AccessioniPrimary (citable) accession number: B2GKR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3