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Protein

Malate dehydrogenase

Gene

mdh

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei113NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciKRHI378753:G1G2M-797-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:KRH_08010
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeKocuria
Proteomesi
  • UP000008838 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916221 – 328Malate dehydrogenaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi378753.KRH_08010

Structurei

3D structure databases

ProteinModelPortaliB2GKC8
SMRiB2GKC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

B2GKC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTPVTVAV TGAAGQIGYS LLFRIAHGDM LGRQRPVRLR LLEIPSALPA
60 70 80 90 100
LEGTVMELQD CAFPLLADVE IGSDPREVFD GAQLALLVGA RPRTKGMERG
110 120 130 140 150
DLLEANGAIF TEQGRALNDV ADHDVRVVVT GNPANTNALI AQRNAPDIPA
160 170 180 190 200
SRFSALTRLD HNRAVAMLAA QTGASVDDVK HLSVWGNHSA TQYPDLDHAR
210 220 230 240 250
VAGRPALDLV SREWVQDTFI PTVAKRGAAI LEARGASSAA SAANATIDHA
260 270 280 290 300
RDLMLGNHRG DWTSMSVVSD GSYGVPEGLV SSFPVTTSGG DWSIVQGLDI
310 320
SEFSRARIDA SVAELESERA AVQELGLI
Length:328
Mass (Da):34,742
Last modified:June 10, 2008 - v1
Checksum:iC9D01EF6F39826DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA Translation: BAG29148.1
RefSeqiWP_012397869.1, NC_010617.1

Genome annotation databases

EnsemblBacteriaiBAG29148; BAG29148; KRH_08010
GeneIDi35827831
KEGGikrh:KRH_08010

Similar proteinsi

Entry informationi

Entry nameiMDH_KOCRD
AccessioniPrimary (citable) accession number: B2GKC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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