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B2GJK0 (B2GJK0_KOCRD) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP MF_00344
EC=6.3.5.2 HAMAP MF_00344
Alternative name(s):
GMP synthetase HAMAP MF_00344
Glutamine amidotransferase HAMAP MF_00344
Gene names
Name:guaA HAMAP MF_00344 EMBL BAG29029.1
Ordered Locus Names:KRH_06820
OrganismKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) [Complete proteome] [HAMAP]
Taxonomic identifier378753 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Kocuria

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00344

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00344

Subunit structure

Homodimer By similarity. HAMAP MF_00344

Sequence similarities

Contains 1 GMP-binding domain. HAMAP MF_00344

Contains 1 glutamine amidotransferase type-1 domain. HAMAP MF_00344

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain15 – 207193Glutamine amidotransferase type-1 By similarity HAMAP MF_00344
Domain239 – 407169GMP-binding By similarity HAMAP MF_00344
Nucleotide binding235 – 2417ATP By similarity HAMAP MF_00344

Sites

Active site921Nucleophile By similarity HAMAP MF_00344
Active site1811 By similarity HAMAP MF_00344
Active site1831 By similarity HAMAP MF_00344

Sequences

Sequence LengthMass (Da)Tools
B2GJK0 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: F2E26EFF27881EFF

FASTA53257,726
        10         20         30         40         50         60 
MTETPDNLSE LEQRPVLVVD YGAQYAQLIA RRVREANVYS EIVPHTWSTE QILQRNPAAL 

        70         80         90        100        110        120 
ILSGGPASVY APGAPQRDAE LFEAGVPVLG ICYGFQVMAA ALGGTVERTG VREYGATTAT 

       130        140        150        160        170        180 
CQDTAVGTLL DGTPDVQTVW MSHGDSVTAA PEGFTTLATT EGAPVAAFEN RERRLYGVQW 

       190        200        210        220        230        240 
HPEVKHSAYG QKILENFLFN GAQLSPTWST GNIIEEQVAA IRAQVGDGKA LCGLSGGVDS 

       250        260        270        280        290        300 
AVAAALVQRA IGDRLTCVLV DHGLMRQDEV EQVEKDYVAA TGVKLHVARE QDRFLEALKG 

       310        320        330        340        350        360 
VTDPETKRKA IGREFIRAFE AAEEKVLRAE AQDGEPVRFL VQGTLYPDVV ESGGGEGAAN 

       370        380        390        400        410        420 
IKSHHNVGGL PEDLQFELVE PLRALFKDEV RAVGRELGLP ENIVGRQPFP GPGLGIRIIG 

       430        440        450        460        470        480 
EVTEHRLDIL RRADAIAREE LTRAGLDDEV WQMPVVLLAD VRSVGVQGDG RTYGHPIVLR 

       490        500        510        520        530 
PVSSEDAMTA DWSRLPSELL ARVSNRITNE VEEINRVVLD VTSKPPGTIE WE

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References

[1]"Complete genome sequence of the soil actinomycete Kocuria rhizophila."
Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S., Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
J. Bacteriol. 190:4139-4146(2008) [PubMed: 18408034] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009152 Genomic DNA. Translation: BAG29029.1.
RefSeqYP_001854535.1. NC_010617.1.

3D structure databases

ProteinModelPortalB2GJK0.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2GJK0.

Protein family/group databases

MEROPSC26.A17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6238045.
GenomeReviewsGene locus KRH_06820 in contig AP009152_GR.
KEGGkrh:KRH_06820.
PATRIC22181604. VBIKocRhi5258_0673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG391775.
OMADGRTYEY.
ProtClustDBPRK00074.

Family and domain databases

HAMAPMF_00344. GMP_synthase.
[Tree]
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2GJK0_KOCRD
AccessionPrimary (citable) accession number: B2GJK0
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info