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B2GIP7

- UPPP_KOCRD

UniProt

B2GIP7 - UPPP_KOCRD

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciKRHI378753:GJ8F-1426-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:KRH_13930
    OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
    Taxonomic identifieri378753 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria
    ProteomesiUP000008838: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Undecaprenyl-diphosphatasePRO_1000197376Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi378753.KRH_13930.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei90 – 11021HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei191 – 21121HelicalUniRule annotationAdd
    BLAST
    Transmembranei227 – 24721HelicalUniRule annotationAdd
    BLAST
    Transmembranei254 – 27421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiIEGPFRD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2GIP7-1 [UniParc]FASTAAdd to Basket

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    MNWIEAIILG LVQGLTEFLP VSSSAHLRIV GEFLPHGGDP GAAFTAITQL    50
    GTETAVILFF WRDIVRIIKQ WALSLTGRVD RKDPDARMGW FIILGSFPIA 100
    VLGLLLQDVI ETQFRSLWIT ATMLIVFGLF LAVADHVGKQ ERHLEDLDVK 150
    HAVGYGFAQA LALIPGVSRS GGTITAGLLM GYTRAAAARY AFLLAIPAVF 200
    SSGLYELYKV LAGKVPAGIY TMGQTAVATV IAFAVGYLII GWFMHYISER 250
    SYSLFVWYRI LLGAAVFVLL GTGILTA 277
    Length:277
    Mass (Da):30,126
    Last modified:June 10, 2008 - v1
    Checksum:i8E03D3DB88D36089
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009152 Genomic DNA. Translation: BAG29740.1.
    RefSeqiWP_012398461.1. NC_010617.1.
    YP_001855246.1. NC_010617.1.

    Genome annotation databases

    EnsemblBacteriaiBAG29740; BAG29740; KRH_13930.
    GeneIDi6239621.
    KEGGikrh:KRH_13930.
    PATRICi22183052. VBIKocRhi5258_1379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009152 Genomic DNA. Translation: BAG29740.1 .
    RefSeqi WP_012398461.1. NC_010617.1.
    YP_001855246.1. NC_010617.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 378753.KRH_13930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG29740 ; BAG29740 ; KRH_13930 .
    GeneIDi 6239621.
    KEGGi krh:KRH_13930.
    PATRICi 22183052. VBIKocRhi5258_1379.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi IEGPFRD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci KRHI378753:GJ8F-1426-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9341 / DSM 348 / NBRC 103217 / DC2201.

    Entry informationi

    Entry nameiUPPP_KOCRD
    AccessioniPrimary (citable) accession number: B2GIP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3