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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciKRHI378753:G1G2M-1392-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:KRH_13930
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeKocuria
Proteomesi
  • UP000008838 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei191 – 211HelicalUniRule annotationAdd BLAST21
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001973761 – 277Undecaprenyl-diphosphataseAdd BLAST277

Interactioni

Protein-protein interaction databases

STRINGi378753.KRH_13930

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

B2GIP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWIEAIILG LVQGLTEFLP VSSSAHLRIV GEFLPHGGDP GAAFTAITQL
60 70 80 90 100
GTETAVILFF WRDIVRIIKQ WALSLTGRVD RKDPDARMGW FIILGSFPIA
110 120 130 140 150
VLGLLLQDVI ETQFRSLWIT ATMLIVFGLF LAVADHVGKQ ERHLEDLDVK
160 170 180 190 200
HAVGYGFAQA LALIPGVSRS GGTITAGLLM GYTRAAAARY AFLLAIPAVF
210 220 230 240 250
SSGLYELYKV LAGKVPAGIY TMGQTAVATV IAFAVGYLII GWFMHYISER
260 270
SYSLFVWYRI LLGAAVFVLL GTGILTA
Length:277
Mass (Da):30,126
Last modified:June 10, 2008 - v1
Checksum:i8E03D3DB88D36089
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA Translation: BAG29740.1
RefSeqiWP_012398461.1, NC_010617.1

Genome annotation databases

EnsemblBacteriaiBAG29740; BAG29740; KRH_13930
GeneIDi35828658
KEGGikrh:KRH_13930

Similar proteinsi

Entry informationi

Entry nameiUPPP_KOCRD
AccessioniPrimary (citable) accession number: B2GIP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health