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B2GI61 (B2GI61_KOCRD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008 EMBL BAG28916.1
Ordered Locus Names:KRH_05690
OrganismKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) [Complete proteome] [HAMAP]
Taxonomic identifier378753 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Kocuria

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451 EMBL BAG28916.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1501 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
B2GI61 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 0CA18A5914ED672E

FASTA27331,227
        10         20         30         40         50         60 
MTEIPTPYED LLRDVLEHGT PKTDRTGTGT LSVFGRQIRY DLSHSFPLLT TKRVHFRSLA 

        70         80         90        100        110        120 
LELLWFLSGS SNVRWLQERG VSIWDEWADE NGDLGPVYGV QWRSWPAGHG ETIDQIARVV 

       130        140        150        160        170        180 
ESIRTTPDSR RHIVTAWNPA EVDRMALPPC HALFQFYVQP REDGPDALSC QLYQRSADLF 

       190        200        210        220        230        240 
LGVPFNIASY ALLTVMVAQQ CDLVPGEFVW TGGDCHIYTN HLEQVRTQLA REPYPYPTLR 

       250        260        270 
LTRRPDSIFD YRFEDFAVEG YQHHPGIKAP VAV

« Hide

References

[1]"Complete genome sequence of the soil actinomycete Kocuria rhizophila."
Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S., Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
J. Bacteriol. 190:4139-4146(2008) [PubMed: 18408034] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009152 Genomic DNA. Translation: BAG28916.1.
RefSeqYP_001854422.1. NC_010617.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2GI61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6239400.
GenomeReviewsGene locus KRH_05690 in contig AP009152_GR.
KEGGkrh:KRH_05690.
PATRIC22181372. VBIKocRhi5258_0558.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMARMALAPC.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2GI61_KOCRD
AccessionPrimary (citable) accession number: B2GI61
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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