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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei199Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRHI378753:G1G2M-1272-MONOMER
UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:KRH_12720
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeKocuria
Proteomesi
  • UP000008838 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001304891 – 414Glucose-1-phosphate adenylyltransferaseAdd BLAST414

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi378753.KRH_12720

Structurei

3D structure databases

ProteinModelPortaliB2GHR6
SMRiB2GHR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 182Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4 Bacteria
COG0448 LUCA
HOGENOMiHOG000278607
KOiK00975
OMAiHCVLGVR
OrthoDBiPOG091H09L2

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

B2GHR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQKKVLAI VLAGGEGKRL MPLTEDRAKP AVPFAGGYRL IDFALSNLVN
60 70 80 90 100
SGYLQIVVLT QYKSHSLDRH LSETWRLSTQ LGNYVTSVPA QQRRGKDWFL
110 120 130 140 150
GSANAIYQSM NLIDDADPDI VVVVGADHVY RMDFADMVEK HIESGAKATV
160 170 180 190 200
AGVRQPMEMV KSFGVIETDP QDPAKITRFV EKPDTTAPLP DDPHSFLASM
210 220 230 240 250
GNYVFDRDAL VEALRTDNEK ADTDHDMGGD IMPYFAERGE AVVYDFTHND
260 270 280 290 300
VPGSTDRDRQ YWRDVGTLES YFDSHMDLIR PLPVFNLYNY DWPIYTHQIM
310 320 330 340 350
APPARTVRGP NGQAGVAFDS IVSPGVLITG GHVGSSVLSP KVKVEHDARV
360 370 380 390 400
TESVLMQNVQ IGAGATVHRC ILDKNVVVPP GTTVGLDREQ DLARGLTVTE
410
SGLTIAPKNY RFER
Length:414
Mass (Da):45,777
Last modified:June 10, 2008 - v1
Checksum:i7A77E5BFB670CD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA Translation: BAG29619.1
RefSeqiWP_012398340.1, NC_010617.1

Genome annotation databases

EnsemblBacteriaiBAG29619; BAG29619; KRH_12720
GeneIDi35828183
KEGGikrh:KRH_12720

Similar proteinsi

Entry informationi

Entry nameiGLGC_KOCRD
AccessioniPrimary (citable) accession number: B2GHR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health