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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei199Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:KRH_12720
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeKocuria
Proteomesi
  • UP000008838 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001304891 – 414Glucose-1-phosphate adenylyltransferaseAdd BLAST414

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi378753.KRH_12720.

Structurei

3D structure databases

ProteinModelPortaliB2GHR6.
SMRiB2GHR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 182Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4. Bacteria.
COG0448. LUCA.
HOGENOMiHOG000278607.
KOiK00975.
OMAiHCVLGVR.
OrthoDBiPOG091H09L2.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00624. GlgC. 1 hit.
InterProiView protein in InterPro
IPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR023049. GlgC_bac.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
PfamiView protein in Pfam
PF00483. NTP_transferase. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiView protein in PROSITE
PS00808. ADP_GLC_PYROPHOSPH_1. 1 hit.
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B2GHR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQKKVLAI VLAGGEGKRL MPLTEDRAKP AVPFAGGYRL IDFALSNLVN
60 70 80 90 100
SGYLQIVVLT QYKSHSLDRH LSETWRLSTQ LGNYVTSVPA QQRRGKDWFL
110 120 130 140 150
GSANAIYQSM NLIDDADPDI VVVVGADHVY RMDFADMVEK HIESGAKATV
160 170 180 190 200
AGVRQPMEMV KSFGVIETDP QDPAKITRFV EKPDTTAPLP DDPHSFLASM
210 220 230 240 250
GNYVFDRDAL VEALRTDNEK ADTDHDMGGD IMPYFAERGE AVVYDFTHND
260 270 280 290 300
VPGSTDRDRQ YWRDVGTLES YFDSHMDLIR PLPVFNLYNY DWPIYTHQIM
310 320 330 340 350
APPARTVRGP NGQAGVAFDS IVSPGVLITG GHVGSSVLSP KVKVEHDARV
360 370 380 390 400
TESVLMQNVQ IGAGATVHRC ILDKNVVVPP GTTVGLDREQ DLARGLTVTE
410
SGLTIAPKNY RFER
Length:414
Mass (Da):45,777
Last modified:June 10, 2008 - v1
Checksum:i7A77E5BFB670CD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA. Translation: BAG29619.1.
RefSeqiWP_012398340.1. NC_010617.1.

Genome annotation databases

EnsemblBacteriaiBAG29619; BAG29619; KRH_12720.
KEGGikrh:KRH_12720.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLGC_KOCRD
AccessioniPrimary (citable) accession number: B2GHR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families