B2GH51 (B2GH51_KOCRD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acs EMBL BAG28803.1
Synonyms:	acsA HAMAP MF_01123
Ordered Locus Names:	KRH_04560

Organism

Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) [Complete proteome] [HAMAP]

Taxonomic identifier

378753 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Kocuria

Protein attributes

Sequence length	649 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL BAG28803.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	516	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	612	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	B2GH51 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 5ECAA8ECA5D09466	FASTA	649	70,868
	10 20 30 40 50 60 MTTDPAAQPK TFAPSEEFAA QANATAELYT QAEEQGEEFW ANQARDLLTW STPFTEVLDW 70 80 90 100 110 120 SNPPFVKWFQ DGTLNAAYNA VDRHVEAGNG DRVALYFEGE PGDSASYTYA QLKDEVSKAA 130 140 150 160 170 180 NAFEALGVGK GDRVAVYLPM IPEAVITMLA CARIGAIHSV VFGGFSADAL RSRIEDGEAK 190 200 210 220 230 240 LVVTADGSYR RGKPTTLKPA VDAALEKGGD TVQHVVVVKR NGEDVAFQDG RDVWWHEITE 250 260 270 280 290 300 NASTEHTPSE QNAEDPLFIL YTSGTTGKPK GILHTTGGYL TQAAFTHKNV FDLKPETDVY 310 320 330 340 350 360 WCTADVGWVT GHTYITYAPL VNGATQVIYE GTPDSPHRGR FWEIVQKYGV SILYTSPTAI 370 380 390 400 410 420 RTMMKWGEEI PAEWDLSSLR LLGTVGEAIN PEAWTWFRRV IGQDRCPIVD TWWQTETGAM 430 440 450 460 470 480 MISPLPGVTA TKPGSAQVPL PGIAVDVVDD AGTSLPNETD GFLVVRKPWP SMLRTIWGDD 490 500 510 520 530 540 ERFVNTYWGQ FGDKYFAGDG AKRDADGDVW ILGRVDDVMN VSGHRLSTPE IESALVSHPS 550 560 570 580 590 600 VAEAAVVGAA DETTGQAVFA FVILSDQATA ENRDAAELAE EIRAHVGREI SPIAKPKKVL 610 620 630 640 IVPELPKTRS GKIMRRLLKD VAEDRPVGDV STLADQTVMQ QIVDSLGTK

References

[1]

"Complete genome sequence of the soil actinomycete Kocuria rhizophila." Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S., Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. J. Bacteriol. 190:4139-4146(2008) [PubMed: 18408034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009152 Genomic DNA. Translation: BAG28803.1.
RefSeq	YP_001854309.1. NC_010617.1.
3D structure databases
ProteinModelPortal	B2GH51.
ModBase	Search...
Protein-protein interaction databases
STRING	B2GH51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6239279.
GenomeReviews	Gene locus KRH_04560 in contig AP009152_GR.
KEGG	krh:KRH_04560.
PATRIC	22181138. VBIKocRhi5258_0444.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	PEAMEST.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2GH51_KOCRD

Accession

Primary (citable) accession number: B2GH51

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)