Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isopentenyl-diphosphate Delta-isomerase

Gene

idi

Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).UniRule annotation

Catalytic activityi

Isopentenyl diphosphate = dimethylallyl diphosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium ion binds only when substrate is bound.UniRule annotation
  • Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: dimethylallyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dimethylallyl diphosphate from isopentenyl diphosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Isopentenyl-diphosphate Delta-isomerase (idi)
This subpathway is part of the pathway dimethylallyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dimethylallyl diphosphate from isopentenyl diphosphate, the pathway dimethylallyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29ManganeseUniRule annotation1
Metal bindingi36ManganeseUniRule annotation1
Active sitei71UniRule annotation1
Metal bindingi73ManganeseUniRule annotation1
Metal bindingi91MagnesiumUniRule annotation1
Metal bindingi118ManganeseUniRule annotation1
Active sitei120UniRule annotation1
Metal bindingi120ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processIsoprene biosynthesis
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciKRHI378753:G1G2M-301-MONOMER
UniPathwayiUPA00059; UER00104

Names & Taxonomyi

Protein namesi
Recommended name:
Isopentenyl-diphosphate Delta-isomeraseUniRule annotation (EC:5.3.3.2UniRule annotation)
Short name:
IPP isomeraseUniRule annotation
Alternative name(s):
IPP:DMAPP isomeraseUniRule annotation
Isopentenyl pyrophosphate isomeraseUniRule annotation
Gene namesi
Name:idiUniRule annotation
Ordered Locus Names:KRH_03040
OrganismiKocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Taxonomic identifieri378753 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeKocuria
Proteomesi
  • UP000008838 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002041131 – 180Isopentenyl-diphosphate Delta-isomeraseAdd BLAST180

Interactioni

Protein-protein interaction databases

STRINGi378753.KRH_03040

Structurei

3D structure databases

ProteinModelPortaliB2GFH1
SMRiB2GFH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IPP isomerase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZEY Bacteria
COG1443 LUCA
HOGENOMiHOG000274107
KOiK01823
OMAiLWWDNLH
OrthoDBiPOG091H03FW

Family and domain databases

CDDicd02885 IPP_Isomerase, 1 hit
HAMAPiMF_00202 Idi, 1 hit
InterProiView protein in InterPro
IPR011876 IsopentenylPP_isomerase_typ1
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
PANTHERiPTHR10885 PTHR10885, 1 hit
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PIRSFiPIRSF018427 Isopntndiph_ism, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
TIGRFAMsiTIGR02150 IPP_isom_1, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

B2GFH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENSTPERV VLLDEQHQPT GTALKSEVHT EATPLHLAFS CHVLNPDGRV
60 70 80 90 100
LVTRRALSKR TWPGVWSNSF CGHPGPHESF EDAIARRARQ ELGLEIRNLT
110 120 130 140 150
VVVPEFQYRA TDATGVVENE FCPVFVAVTD TDPQPAESEV AEYAWTAPRD
160 170 180
LIAAVESAPY AFSPWLGDQV REPALREALG
Length:180
Mass (Da):19,902
Last modified:June 10, 2008 - v1
Checksum:iA69A9280FDDDB452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009152 Genomic DNA Translation: BAG28651.1
RefSeqiWP_012397378.1, NC_010617.1

Genome annotation databases

EnsemblBacteriaiBAG28651; BAG28651; KRH_03040
GeneIDi35826809
KEGGikrh:KRH_03040

Similar proteinsi

Entry informationi

Entry nameiIDI_KOCRD
AccessioniPrimary (citable) accession number: B2GFH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 10, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health