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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Lactobacillus fermentum (strain NBRC 3956 / LMG 18251)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:LAF_0036
OrganismiLactobacillus fermentum (strain NBRC 3956 / LMG 18251)
Taxonomic identifieri334390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003793711 – 1245ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1245

Interactioni

Subunit structurei

Heterodimer of AddA and RexB.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033806.
KOiK16899.
OMAiDYKSSAK.
OrthoDBiPOG091H01PC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B2GEY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLQFVLGS ASFDHQQVML DRLAAQYQQA PNDTYLYLVP NHVKFTTEVA
60 70 80 90 100
VLKGLKKRLK QTGNYAQANV AVLSFSRLGW FLCKDDPDYQ KPRLSNVGMA
110 120 130 140 150
MVVAKIIREL KAESPDLLKM FRGESERQGF ATEVTKQLVE LQNANIQPAD
160 170 180 190 200
LAPDQETGII KRALASQAGG GRASQSTVFT DKMTVLYEIY RRFEAAVTTH
210 220 230 240 250
VTAPDRSAML LNHLEAADLS TTHVYLDRFA GEFSAQEQLI VDALIQRAAD
260 270 280 290 300
TTVSLILDRD YRGRELPSQN NLYYRSAKQY QDLLNLATQQ VGVDVLDPIV
310 320 330 340 350
LNQPNQRRVS DALVGVEEWM EADARFALPD RLPAPTDQVG FFTAPTRVAE
360 370 380 390 400
LNRVATKIRQ LVATGQYRYR DFLVVTRHLD GYQTMLEPIF SRHQIPVFND
410 420 430 440 450
NQRPMATSPL ATFTAALFKV LKDYYQEADV MELLKTGLLV PETPEELQQE
460 470 480 490 500
GRAKRNPNTF MTAVYRTENY CLKFGKGGRS WFDERPWRLE GEQPESDALK
510 520 530 540 550
RQNAQINWVK NYIKDELAPA LADLQTATTG RELATKFYQF LLDQGVRHQL
560 570 580 590 600
YSWAHQAQES GQLTQLRDVQ QIWQTFGTLL DEYVTILGDQ VAPTEQPGQL
610 620 630 640 650
VAEFADLMNA GFNAGRYAQI PSTLDQVLVS ESGMIQDNQR KVLFIMGATD
660 670 680 690 700
DVMPEVKASE GLLSDPDREL LKRGLNDDQF LPISGTDQIN NEPFLNYLSM
710 720 730 740 750
LSVTERLYMS APLMSSDDSE LTLSPYLKGL ARHFNQWDDQ NNAPTTDLPD
760 770 780 790 800
RPNPRASEDD VWSFVAAPAV TMGNLIEVER LSKDTGRKLT SAWRDVARAL
810 820 830 840 850
TRYDEGLTGR LNDIRDGQYA KNEAVPLQPE LAARLYTTNR QGQVTNQLTA
860 870 880 890 900
SISQLEKFYQ NPYDYFLRYG LHLKKRDELE VSSDKSGTLN HDALAFFVQS
910 920 930 940 950
VIDEPDLQLA DLVKEEHQGR QAELIDQAFE QAMNQQEELR ELAANNSRVN
960 970 980 990 1000
LQLQVAKQLI TTMAKTLCLQ ATQTDAQPVA VEKAFGQADW TGESQAAELP
1010 1020 1030 1040 1050
ALTFDLTGAG LGEGAKVSLR GRIDRLDELK LGEQTYQLVV DYKSYNKAFD
1060 1070 1080 1090 1100
LVDAYAGQAL QMLAYLNALQ AANPGKQLLG SLYLRLYVPT VDAGKEGTAE
1110 1120 1130 1140 1150
ELKEHLYQGI TINDDAVLAA LDHGLGEKGA TLLSIKKKSK KDTSRFKVSA
1160 1170 1180 1190 1200
DDQFSAKAGS NLVSPTDLKR LMDHNAELIK EAAVQILQGQ NEIRPYRRQV
1210 1220 1230 1240
GTTAETGLAF SDFLDVSRFD QALDDYKEIE LTDADVEAKF EQEEE
Length:1,245
Mass (Da):139,712
Last modified:June 10, 2008 - v1
Checksum:iD5F1763E5632E992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008937 Genomic DNA. Translation: BAG26372.1.
RefSeqiWP_012390673.1. NC_010610.1.

Genome annotation databases

EnsemblBacteriaiBAG26372; BAG26372; LAF_0036.
GeneIDi6233609.
KEGGilfe:LAF_0036.
PATRICi22224006. VBILacFer15497_0035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008937 Genomic DNA. Translation: BAG26372.1.
RefSeqiWP_012390673.1. NC_010610.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG26372; BAG26372; LAF_0036.
GeneIDi6233609.
KEGGilfe:LAF_0036.
PATRICi22224006. VBILacFer15497_0035.

Phylogenomic databases

HOGENOMiHOG000033806.
KOiK16899.
OMAiDYKSSAK.
OrthoDBiPOG091H01PC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADDB_LACF3
AccessioniPrimary (citable) accession number: B2GEY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.