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B2GDY8 (UPPP_LACF3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LAF_1534
OrganismLactobacillus fermentum (strain NBRC 3956 / LMG 18251) [Complete proteome] [HAMAP]
Taxonomic identifier334390 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197378

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2GDY8 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 486324C8C3E20737

FASTA27630,754
        10         20         30         40         50         60 
MLEILKAVIL GIVEGITEFL PISSTGHLVL VDEFIKLNEP KKFIDMFNVV IQLGAIMAVV 

        70         80         90        100        110        120 
VLYFHKLNPW SPKKSRLERS QTWTLWKKVI IAVIPSVIIG LPLNDWMDAH LMNWLVVSIA 

       130        140        150        160        170        180 
LIVYGVLFIV IENHNQNLRP RFDSLNTLPY KVAILIGCFQ ILSLIPGTSR SGATILGAIL 

       190        200        210        220        230        240 
IGTSRYVAAE FSFFLAIPTM FGASLLKLYK FFAHGGTLAG NQGLILAVGV IVSFVVAYAS 

       250        260        270 
IRFLLNYIKT KDFKAFGWYR IILGVIVIAY FALLAH 

« Hide

References

[1]"Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBRC 3956 / LMG 18251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008937 Genomic DNA. Translation: BAG27870.1.
RefSeqYP_001844350.1. NC_010610.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING334390.LAF_1534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG27870; BAG27870; LAF_1534.
GeneID6232020.
KEGGlfe:LAF_1534.
PATRIC22227432. VBILacFer15497_1683.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAMILVEEF.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycLFER334390:GJ2S-1597-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_LACF3
AccessionPrimary (citable) accession number: B2GDY8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families