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B2GCS5 (B2GCS5_LACF3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase HAMAP MF_00186
EC=2.7.1.30 HAMAP MF_00186
Alternative name(s):
ATP:glycerol 3-phosphotransferase HAMAP MF_00186
Glycerokinase HAMAP MF_00186
Gene names
Name:glpK HAMAP MF_00186
Ordered Locus Names:LAF_1121
OrganismLactobacillus fermentum (strain NBRC 3956 / LMG 18251) [Complete proteome] [HAMAP]
Taxonomic identifier334390 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186 SAAS SAAS018483

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186 SAAS SAAS018483

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186 SAAS SAAS018483

Sequence similarities

Belongs to the FGGY kinase family. HAMAP MF_00186 RuleBase RU003733

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding412 – 4165ATP By similarity HAMAP MF_00186

Sites

Binding site141Substrate By similarity HAMAP MF_00186
Binding site181ATP By similarity HAMAP MF_00186
Binding site841Substrate By similarity HAMAP MF_00186
Binding site1361Substrate By similarity HAMAP MF_00186
Binding site2461Substrate By similarity HAMAP MF_00186
Binding site2681ATP By similarity HAMAP MF_00186
Binding site3111ATP; via carbonyl oxygen By similarity HAMAP MF_00186

Sequences

Sequence LengthMass (Da)Tools
B2GCS5 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: ECC9446C1DD38388

FASTA50355,634
        10         20         30         40         50         60 
MNEQQYVMAI DEGTTSSRAI IFDHAGKEVA IAQKEFRQYF PQPGWVEHDA EEIWDSVQSV 

        70         80         90        100        110        120 
ISEAVIKAQV KPYRIVAIGI TNQRETTVIW DRKTGKPIAR AIVWQSKQTA PIAERLIEEG 

       130        140        150        160        170        180 
YTDQIHQKTG LVIDSYFSAT KIKWLLDNVP GARERAKRGD LLFGTIDTWL LWNLTSGRVH 

       190        200        210        220        230        240 
ATDVTNASRT MLFNIHTLDW DQDILDLLDI PREILPEVKP SSHVYGYTAD YHFFGVQVPV 

       250        260        270        280        290        300 
AGIAGDQQAA LFGQGAFEKG SVKNTYGTGA FTVMNTGTTP MLSQNGLLTT VAYGIGNEVH 

       310        320        330        340        350        360 
YALEGSIFVA GSAVQWLRDG LRLFKSAGES EQMAVDAQTT GGVYVVPSFT GLGAPYWDQE 

       370        380        390        400        410        420 
VRGAMFGLTR GSSRENIVRA TLEAIAYQTK DVVDTMVKDT NLPLTTLAVD GGASRNNFMM 

       430        440        450        460        470        480 
QFQADLLQTP IVRAQIEETT ALGAAFLAGL AVDFWEDQNE LKQLAKSGDR FDPVMTKEEA 

       490        500 
GRHYAGWQRA VDAVRYFSHG AEE

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References

[1]"Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
DNA Res. 15:151-161(2008) [PubMed: 18487258] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBRC 3956 / LMG 18251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008937 Genomic DNA. Translation: BAG27457.1.
RefSeqYP_001843937.1. NC_010610.1.

3D structure databases

ProteinModelPortalB2GCS5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2GCS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6231918.
GenomeReviewsGene locus LAF_1121 in contig AP008937_GR.
KEGGlfe:LAF_1121.
PATRIC22226510. VBILacFer15497_1239.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMASHSAETE.
ProtClustDBCLSK849172.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2GCS5_LACF3
AccessionPrimary (citable) accession number: B2GCS5
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info