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B2GBC2

- EFTU_LACF3

UniProt

B2GBC2 - EFTU_LACF3

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Protein
Elongation factor Tu
Gene
tuf, LAF_0618
Organism
Lactobacillus fermentum (strain NBRC 3956 / LMG 18251)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTP By similarity
Nucleotide bindingi82 – 865GTP By similarity
Nucleotide bindingi137 – 1404GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLFER334390:GJ2S-662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf
Ordered Locus Names:LAF_0618
OrganismiLactobacillus fermentum (strain NBRC 3956 / LMG 18251)
Taxonomic identifieri334390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001697: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Elongation factor TuUniRule annotation
PRO_1000095070Add
BLAST

Proteomic databases

PRIDEiB2GBC2.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi334390.LAF_0618.

Structurei

3D structure databases

ProteinModelPortaliB2GBC2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 205195tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 278G1 By similarity
Regioni61 – 655G2 By similarity
Regioni82 – 854G3 By similarity
Regioni137 – 1404G4 By similarity
Regioni175 – 1773G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDNIEMVG.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2GBC2-1 [UniParc]FASTAAdd to Basket

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MAEKEHYERT KPHVNIGTIG HVDHGKTTLT AAITKVLAAK GLAKAEDYSD    50
IDAAPEEKER GITINTAHVE YETEKRHYAH IDAPGHADYV KNMITGAAQM 100
DGAILVVAAT DGPMPQTREH ILLARQVGVE YIVVFLNKTD LVDDDELVDL 150
VEMEVRDLLS EYDFPGDDVP VVRGSALKAL EGDPEQEQVV LHLLDVVDEY 200
IPTPKRPTDK PFMMPVEDVF TITGRGTVAS GRIDRGTVKI GDEVEIVGLK 250
EDVIKSTVTG VEMFHKTLDL GEAGDNVGIL LRGVSHDQIE RGQVLAEPGS 300
IQTHKQFKGE VYVMTKEEGG RHTPFFSNYR PQFYFHTTDV TGTIELPDGV 350
EMVMPGDNVT FTVELQKPVA LEKGLKFTIR EGGHTVGAGV VSEVLD 396
Length:396
Mass (Da):43,474
Last modified:June 10, 2008 - v1
Checksum:i7F315221B5C21AF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008937 Genomic DNA. Translation: BAG26954.1.
RefSeqiWP_012391019.1. NC_010610.1.
YP_001843434.1. NC_010610.1.

Genome annotation databases

EnsemblBacteriaiBAG26954; BAG26954; LAF_0618.
GeneIDi6231814.
KEGGilfe:LAF_0618.
PATRICi22225354. VBILacFer15497_0664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008937 Genomic DNA. Translation: BAG26954.1 .
RefSeqi WP_012391019.1. NC_010610.1.
YP_001843434.1. NC_010610.1.

3D structure databases

ProteinModelPortali B2GBC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 334390.LAF_0618.

Proteomic databases

PRIDEi B2GBC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG26954 ; BAG26954 ; LAF_0618 .
GeneIDi 6231814.
KEGGi lfe:LAF_0618.
PATRICi 22225354. VBILacFer15497_0664.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi DNIEMVG.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci LFER334390:GJ2S-662-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
    Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
    DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBRC 3956 / LMG 18251.

Entry informationi

Entry nameiEFTU_LACF3
AccessioniPrimary (citable) accession number: B2GBC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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