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B2GAM7

- UNG_LACF3

UniProt

B2GAM7 - UNG_LACF3

Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Lactobacillus fermentum (strain NBRC 3956 / LMG 18251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

    Catalytic activityi

    Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciLFER334390:GJ2S-395-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
    Short name:
    UDGUniRule annotation
    Gene namesi
    Name:ungUniRule annotation
    Ordered Locus Names:LAF_0373
    OrganismiLactobacillus fermentum (strain NBRC 3956 / LMG 18251)
    Taxonomic identifieri334390 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001697: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Uracil-DNA glycosylasePRO_1000096589Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi334390.LAF_0373.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uracil-DNA glycosylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0692.
    HOGENOMiHOG000229528.
    KOiK03648.
    OMAiSHSNFGW.
    OrthoDBiEOG6MSS63.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_00148. UDG.
    InterProiIPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR11264. PTHR11264. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00628. ung. 1 hit.
    PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2GAM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQLINNDWW PVLKPQFETA NYQQLHNFLV DEYGHQQVYP EMHHIFEAFN    50
    WTPFSKVKVV ILGQDPYHGP GQAHGCSFSV LPGVAVPPSL QNIYKELQAD 100
    LGCPPVKHGY LRSWAEQGVL LLNSVLTVRA GQAYSHQGHG WEQLTDAAIV 150
    ALSKRPTPVV FILWGRAARD KKRLIDLKRN FVVESAHPSP LSAYRGFFGS 200
    RPFSKTNQFL EMTGQAPINW QLPSTVDHL 229
    Length:229
    Mass (Da):25,937
    Last modified:June 10, 2008 - v1
    Checksum:iA06781A527E3AB6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008937 Genomic DNA. Translation: BAG26709.1.
    RefSeqiYP_001843189.1. NC_010610.1.

    Genome annotation databases

    EnsemblBacteriaiBAG26709; BAG26709; LAF_0373.
    GeneIDi6232424.
    KEGGilfe:LAF_0373.
    PATRICi22224790. VBILacFer15497_0406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008937 Genomic DNA. Translation: BAG26709.1 .
    RefSeqi YP_001843189.1. NC_010610.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 334390.LAF_0373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG26709 ; BAG26709 ; LAF_0373 .
    GeneIDi 6232424.
    KEGGi lfe:LAF_0373.
    PATRICi 22224790. VBILacFer15497_0406.

    Phylogenomic databases

    eggNOGi COG0692.
    HOGENOMi HOG000229528.
    KOi K03648.
    OMAi SHSNFGW.
    OrthoDBi EOG6MSS63.

    Enzyme and pathway databases

    BioCyci LFER334390:GJ2S-395-MONOMER.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_00148. UDG.
    InterProi IPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR11264. PTHR11264. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00628. ung. 1 hit.
    PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
      Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
      DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBRC 3956 / LMG 18251.

    Entry informationi

    Entry nameiUNG_LACF3
    AccessioniPrimary (citable) accession number: B2GAM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3