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B2G944 (HEMH_LACRJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:LAR_1460
OrganismLactobacillus reuteri (strain JCM 1112) [Complete proteome] [HAMAP]
Taxonomic identifier557433 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Ferrochelatase HAMAP MF_00323
PRO_1000116056

Sites

Metal binding1841Iron By similarity
Metal binding2651Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B2G944 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: C4A5EAD080FE7FBD

FASTA31035,387
        10         20         30         40         50         60 
MKKNGLLLVN LGSPDTPTTP DVKRYLKEFL SDRNVIEMPP ALWQPLLRGI ILPTRSWRSA 

        70         80         90        100        110        120 
TFYRNCWTKD GSPLIVYTER LVAKVQGLMP EWVVKMAMTY GKPKISDTIT GMKKECQNIT 

       130        140        150        160        170        180 
VLPLFPFFTK STTQTVIDKV KDADPEAKII DRFSAEEDYL DLLAKQIQTA WDRGKYDKLL 

       190        200        210        220        230        240 
ISYHGIPTAM VNHGDPYRDE TEAATAELIK RLDIPEKQIK MAYQSKFGPM PWLKPYLRNT 

       250        260        270        280        290        300 
LLNEAQLGHR DVLVVAPSFV ADCLETLEED QVQNYQVFRE NGGNNLVMVP SLNDSPEFAQ 

       310 
FITDLVQRKG

« Hide

References

[1]"Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
DNA Res. 15:151-161(2008) [PubMed: 18487258] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 1112.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP007281 Genomic DNA. Translation: BAG25976.1.
RefSeqYP_001842456.1. NC_010609.1.

3D structure databases

ProteinModelPortalB2G944.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2G944.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6231013.
GenomeReviewsGene locus LAR_1460 in contig AP007281_GR.
KEGGlrf:LAR_1460.
PATRIC22260549. VBILacReu111271_1609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBCLSK821272.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LACRJ
AccessionPrimary (citable) accession number: B2G944
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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