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B2G8D8

- SYR_LACRJ

UniProt

B2G8D8 - SYR_LACRJ

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Lactobacillus reuteri (strain JCM 1112)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLREU557433:GHNR-1265-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
    Alternative name(s):
    Arginyl-tRNA synthetaseUniRule annotation
    Short name:
    ArgRSUniRule annotation
    Gene namesi
    Name:argSUniRule annotation
    Ordered Locus Names:LAR_1204
    OrganismiLactobacillus reuteri (strain JCM 1112)
    Taxonomic identifieri557433 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000009150: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Arginine--tRNA ligasePRO_1000095376Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi557433.LAR_1204.

    Structurei

    3D structure databases

    ProteinModelPortaliB2G8D8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi121 – 13111"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247211.
    KOiK01887.
    OMAiYVKFHDE.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2G8D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKQQVAAA LAQALPEMDV KEIEAKIERP KDSSNGDYAF PTFFLAKTLH    50
    KAPQMIASEL VEKVDQNGFE KVVVAGPYIN FFLDKAQVGA KILQTILADP 100
    EHYGEIDLGH QSNVTIDYSS PNIAKPMGMG HLRSTMIGEA VARILEKVNY 150
    NLIRIDYLGD WGTQFGKLMA AYEMWGDEAE VKKDPINTLL KYYVRINNEA 200
    DEHPEYTEAG RNWFAKLEHG DEEAWRLWHW FREVSLERFQ RVYKMLDVNF 250
    DSFNGEAFSA QKMEEPIQLL RDKDLLKPSR GAEIVDLDEY NLPPLLIIKS 300
    NGTTTYITRD LATALFRKRM YGHAKSLYVV GAEQETYFKQ LRAALKEMGF 350
    NWWDQIEHIS FGLMNLNGKK MSTRKGNVVS LEDVLNDSID LARKQIAEKN 400
    PDLENADEVA KEVGVGAVIF HDLKNYRRNA VNFKLEDVVK FEGETGPYVQ 450
    YARARAESIL RKGGIRDFSD VDLTKAGAEA WELISFLGQY SEAIKRAALN 500
    YDPSVIAKYA LELAKKFNQY YAHTRILDKD EAQPARLALT QAVSDVLKSA 550
    LDLLDIKAPD EM 562
    Length:562
    Mass (Da):63,879
    Last modified:June 10, 2008 - v1
    Checksum:i2CC1383DE68EEF03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007281 Genomic DNA. Translation: BAG25720.1.
    RefSeqiYP_001842200.1. NC_010609.1.

    Genome annotation databases

    EnsemblBacteriaiBAG25720; BAG25720; LAR_1204.
    GeneIDi6231107.
    KEGGilrf:LAR_1204.
    PATRICi22259930. VBILacReu111271_1321.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007281 Genomic DNA. Translation: BAG25720.1 .
    RefSeqi YP_001842200.1. NC_010609.1.

    3D structure databases

    ProteinModelPortali B2G8D8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557433.LAR_1204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG25720 ; BAG25720 ; LAR_1204 .
    GeneIDi 6231107.
    KEGGi lrf:LAR_1204.
    PATRICi 22259930. VBILacReu111271_1321.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247211.
    KOi K01887.
    OMAi YVKFHDE.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci LREU557433:GHNR-1265-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
      Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
      DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 1112.

    Entry informationi

    Entry nameiSYR_LACRJ
    AccessioniPrimary (citable) accession number: B2G8D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3